{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:55:03Z","timestamp":1787025303645,"version":"build-2736575974"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Introduction<\/jats:italic>\n                    <\/jats:bold>\n                    . It is known that hyperlipidemia reduces hearing functions. In this study, we aimed to study the effect of antihyperlipidemic drugs on hearing functions and tinnitus.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods<\/jats:italic>\n                    <\/jats:bold>\n                    . Eighty-four patients aged 18 to 84, who were diagnosed with hyperlipidemia and started treatment with the statin group (atorvastatin 20 mg and 40 mg, rosuvastatin 10 mg and 20 mg, and simvastatin 20 mg) of antihyperlipidemic drugs, were included in this study. All patients underwent pure-tone audiometry before starting treatment with antihyperlipidemic drugs. Patients with tinnitus were evaluated by Tinnitus Severity Index and Visual Analogue Scale. In the 6th month of therapy, otologic examination, pure-tone audiometry and tinnitus evaluation of the patients were repeated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results<\/jats:italic>\n                    <\/jats:bold>\n                    . No significant difference was found in the pure-tone averages of the patients before and after statin use (p &gt; 0.05). However, it was found in the audiometry that, after statin use, all drugs caused to statistically significant decrease in the hearing thresholds at 6000 Hertz (p &lt; 0.05). Also, a strong increase was found in the Speech Discrimination percentages after treatment in patients using rosuvastatin 10 mg (p = 0.022). A significant decrease was found in the tinnitus frequency, duration, severity and degree of annoyance in patients using rosuvastatin 10 mg and 20 mg (p &lt; 0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusion<\/jats:italic>\n                    <\/jats:bold>\n                    . Statin group of drugs can have a positive effect on the hearing functions and subjective tinnitus. In particular, it is seen that rosuvastatin group of statins has a more notable effect on tinnitus. It was considered that further studies with larger patient groups are needed.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2018-0035","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T04:33:09Z","timestamp":1542429189000},"page":"133-140","source":"Crossref","is-referenced-by-count":6,"title":["Effect of statins on hearing function and subjective tinnitus in hyperlipidemic patients"],"prefix":"10.2478","volume":"57","author":[{"given":"Hilal","family":"Y\u00fccel","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology , Health Sciences University , Meram Education and Research Hospital , Konya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abitter","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology , Health Sciences University , Meram Education and Research Hospital , Konya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Arba\u011f","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery , Necmettin Erbakan University , Konya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Cure","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Camlica Erdem Hospital , Uskudar, Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Akif","family":"Eryilmaz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery , Necmettin Erbakan University , Konya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Bedri","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery , Medicana International Hospital , \u0130stanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"2026042914160807027_j_rjim-2018-0035_ref_001_w2aab3b7b2b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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J Am Coll Cardiol. 2000;35(1):1-10.10.1016\/S0735-1097(99)00525-2","DOI":"10.1016\/S0735-1097(99)00525-2"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_017_w2aab3b7b2b1b6b1ab1ac17Aa","doi-asserted-by":"crossref","unstructured":"17. BORGHI C., MODUGNO C., PIRADDA A. Possible Role of HMG-CO A Reductase inhibitors for the treatment of sudden sensorineural hearing loss (SSHL). Med Hypotheses. 2002;58(5):399-402.10.1054\/mehy.2001.153512056877","DOI":"10.1054\/mehy.2001.1535"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_018_w2aab3b7b2b1b6b1ab1ac18Aa","doi-asserted-by":"crossref","unstructured":"18. CAI Q., DU X., ZHOU B., CAI C., KERMANY MH., ZHANG C., et al. Effects of Simvastatin on plasma lipoproteins and hearing loss in apolipoprotein E gene\u2013deficient mice. ORL J Otorhinolaryngol Relat Spec. 2009;71(5):244-50.10.1159\/00023601419738398","DOI":"10.1159\/000236014"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_019_w2aab3b7b2b1b6b1ab1ac19Aa","doi-asserted-by":"crossref","unstructured":"19. SYKA J., OUDA L., NACHTIGAL P., SOLICHOVA D., SEMECK\u00dd V. Atorvastatin slows down deterioration of inner ear function with age in mice. Neurosci Lett. 2007;411(2):112-6.10.1016\/j.neulet.2006.10.03217084973","DOI":"10.1016\/j.neulet.2006.10.032"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_020_w2aab3b7b2b1b6b1ab1ac20Aa","doi-asserted-by":"crossref","unstructured":"20. OLZOWY B., CANIS M., HEMPEL JM., MAZUREK B., SUCKFULL M. Effect of atorvastatin on progression of sensorineural hearing loss and tinnitus in the elderly. Otol Neurotol. 2007;28(4):455-8.10.1097\/01.mao.0000271673.33683.7b17529847","DOI":"10.1097\/01.mao.0000271673.33683.7b"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_021_w2aab3b7b2b1b6b1ab1ac21Aa","doi-asserted-by":"crossref","unstructured":"21. CHUNG SD., CHEN CH., HUNG SH., LIN HC., WANGLH. A population-based study on the association between statin use and sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 2015;152(2):319-25.10.1177\/019459981455938225450412","DOI":"10.1177\/0194599814559382"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_022_w2aab3b7b2b1b6b1ab1ac22Aa","doi-asserted-by":"crossref","unstructured":"22. L\u0130U M., ALAFR\u0130S A., LONGO AJ., COHEN H. Irreversible atorvastatin-associated hearing loss. Pharmacotherapy. 2012;32(2):e27-34.10.1002\/PHAR.104022392429","DOI":"10.1002\/PHAR.1040"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_023_w2aab3b7b2b1b6b1ab1ac23Aa","doi-asserted-by":"crossref","unstructured":"23. S\u0130ERRA S., RAMOS MC., MOL\u0130NA P., ESTEO C., V\u00c1ZQUEZ JA., BURGOS JS. Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death. J Alzheimers Dis. 2011;23(2):307-18.10.3233\/JAD-2010-10117921098985","DOI":"10.3233\/JAD-2010-101179"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_024_w2aab3b7b2b1b6b1ab1ac24Aa","doi-asserted-by":"crossref","unstructured":"24. MELO JJ., MENESES CL., MARCHIORI LL. Prevalence of tinnitus in elderly individuals with and without history of occupational noise exposure. Int Arch Otorhinolaryngol. 2012;16(2):222-5.10.7162\/S1809-97772012000200011439959125991939","DOI":"10.7162\/S1809-97772012000200011"},{"key":"2026042914160807027_j_rjim-2018-0035_ref_025_w2aab3b7b2b1b6b1ab1ac25Aa","doi-asserted-by":"crossref","unstructured":"25. MOLLER AR. Pathophysiology of Tinnitus. 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