{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:44:34Z","timestamp":1777776274659,"version":"3.51.4"},"reference-count":7,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Although type 1 diabetes mellitus is largely associated with autoimmune thyroid disease and this entity has been recently referred to as autoimmune polyglandular syndrome type 3 variant, the autoimmune polyglandular syndrome type 3 variant in patients with rheumatoid arthritis has not been reported so far. We herein describe the first case of rheumatoid arthritis that was associated with autoimmune polyglandular syndrome type 3 variant.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case report.<\/jats:bold>\n                    A 77-year-old woman with a 15-year history of rheumatoid arthritis (RA) and a 10-year history of type 2 diabetes mellitus (T2D) presented with polyarthralgia and hyperglycaemia. Methotrexate 16 mg\/week had been started from the onset and was continued, and adalimumab 40 mg\/day was started for RA. Insulin treatment was also started for the diabetes. Laboratory examinations revealed high levels of C-reactive protein (CRP), rheumatoid factor, anti-cyclic citrullinated peptide antibody, and matrix metalloprotease 3. She was admitted multiple times as the symptoms recurred after treatment. Subsequently, based on the clinical course and investigations, she was diagnosed with type 1 diabetes mellitus and Graves\u2019 disease occurring during the course of RA and T2D. Her clinical course improved after reinforcement of insulin therapy and the addition of thiamazole therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    In patients with rheumatoid arthritis, the autoimmune polyglandular syndrome type 3 variant should be considered as the cause of the deterioration.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2019-0024","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T04:04:20Z","timestamp":1574395460000},"page":"40-43","source":"Crossref","is-referenced-by-count":4,"title":["Autoimmune polyglandular syndrome type 3 variant in rheumatoid arthritis"],"prefix":"10.2478","volume":"58","author":[{"given":"Taro","family":"Horino","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School , Kochi University , Kohasu, Oko-cho, Nankoku , Kochi 783-8505 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School , Kochi University , Kohasu, Oko-cho, Nankoku , Kochi 783-8505 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ichii","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Basic Veterinary Sciences , Faculty of Veterinary Medicine , Hokkaido University , Kita 18, Nishi 9, Kita-Ku, Sapporo , 060-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School , Kochi University , Kohasu, Oko-cho, Nankoku , Kochi 783-8505 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"2026042914160249971_j_rjim-2019-0024_ref_001_w2aab3b8c12b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. MICHELS AW., GOTTLIEB PA. Autoimmune polyglandular syndromes. Nat Rev Endocrinol. 2010; 6(5):270\u20137.10.1038\/nrendo.2010.40","DOI":"10.1038\/nrendo.2010.40"},{"key":"2026042914160249971_j_rjim-2019-0024_ref_002_w2aab3b8c12b1b7b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. KAHALY GJ., FROMMER L. Polyglandular autoimmune syndromes. J Endocrinol Invest. 2018; 41(1):91\u201398.10.1007\/s40618-017-0740-9","DOI":"10.1007\/s40618-017-0740-9"},{"key":"2026042914160249971_j_rjim-2019-0024_ref_003_w2aab3b8c12b1b7b1ab1ab3Aa","doi-asserted-by":"crossref","unstructured":"3. HUBER A., MENCONI F., CORATHERS S., JACOBSON EM., TOMER Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev. 2008; 29(6):697\u2013725.10.1210\/er.2008-0015","DOI":"10.1210\/er.2008-0015"},{"key":"2026042914160249971_j_rjim-2019-0024_ref_004_w2aab3b8c12b1b7b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. GRUBIC Z., ROJNIC PUTAREK N., MASKALAN M., ZUNEC R., STINGL JANKOVIC K., BUREK KAMENARIC M., et al. Human Leukocyte Antigen class II polymorphisms among Croatian patients with type 1 diabetes and autoimmune polyglandular syndrome type 3 variant. Gene. 2018; 674:93\u201397.10.1016\/j.gene.2018.06.083","DOI":"10.1016\/j.gene.2018.06.083"},{"key":"2026042914160249971_j_rjim-2019-0024_ref_005_w2aab3b8c12b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. D\u2019ANTONA L., et al. Prevalence of undiagnosed diabetes in rheumatoid arthritis: an OGTT Study. Medicine (Baltimore). 2016; 95(7):e2552.10.1097\/MD.0000000000002552","DOI":"10.1097\/MD.0000000000002552"},{"key":"2026042914160249971_j_rjim-2019-0024_ref_006_w2aab3b8c12b1b7b1ab1ab6Aa","doi-asserted-by":"crossref","unstructured":"6. DOUGADOS M., SOUBRIER M., ANTUNEZ A., BALINT P., BALSA A., BUCH MH., et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis. 2014; 73(1):62\u20138.10.1136\/annrheumdis-2013-204223","DOI":"10.1136\/annrheumdis-2013-204223"},{"key":"2026042914160249971_j_rjim-2019-0024_ref_007_w2aab3b8c12b1b7b1ab1ab7Aa","doi-asserted-by":"crossref","unstructured":"7. NAIK RG., BROOKS-WORRELL BM., PALMER JP. Latent autoimmune diabetes in adults. J Clin Endocrinol Metab. 2009; 94(12):4635\u201344.10.1210\/jc.2009-1120","DOI":"10.1210\/jc.2009-1120"}],"container-title":["Romanian Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/rjim\/58\/1\/article-p40.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/rjim-2019-0024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:21:27Z","timestamp":1777486887000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/rjim-2019-0024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,1]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,3,3]]},"published-print":{"date-parts":[[2020,3,1]]}},"alternative-id":["10.2478\/rjim-2019-0024"],"URL":"https:\/\/doi.org\/10.2478\/rjim-2019-0024","relation":{},"ISSN":["2501-062X"],"issn-type":[{"value":"2501-062X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,1]]}}}