{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:09:44Z","timestamp":1777777784657,"version":"3.51.4"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Introduction.<\/jats:italic>\n                    <\/jats:bold>\n                    Studies regarding antibiotics administration during pregnancy and atopic dermatitis (AD) in children are only few. In this context, the objective of our study was to investigate the potential association between the timing of intrauterine exposure to antibiotics or prenatal antibiotic administration in general and AD occurrence in children.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods.<\/jats:italic>\n                    <\/jats:bold>\n                    This was a cross-sectional study in 1046 subjects. The exposure to antibiotics during pregnancy was initially evaluated using simple logistic regressions. Then, each period of antibiotics administration was adjusted with the other periods of antibiotics exposure (model 1) and with the other variables associated with AD in our database (model 2).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results.<\/jats:italic>\n                    <\/jats:bold>\n                    In simple logistic regression analysis, the administration of antibiotics during pregnancy, as a whole period, presented a trend of association with AD (OR = 1.28, %CI: 0.99 \u2013 1.65). When we analyzed antibiotic administration during each trimester of pregnancy, only antibiotherapy during the 3\n                    <jats:sup>rd<\/jats:sup>\n                    trimester was associated with AD (OR = 2.94, %CI: 1.21 \u2013 7.12). After adjusting with all the other important risk factors associated with AD in the database, antibiotics administration during the 3\n                    <jats:sup>rd<\/jats:sup>\n                    trimester of pregnancy was still independently associated with AD (OR=2.64, %CI: 1.01 \u2013 6.91).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusion.<\/jats:italic>\n                    <\/jats:bold>\n                    Antibiotic administration during the 3\n                    <jats:sup>rd<\/jats:sup>\n                    trimester of pregnancy was independently associated with AD in children.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2020-0006","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T10:22:49Z","timestamp":1585650169000},"page":"99-107","source":"Crossref","is-referenced-by-count":5,"title":["Antibiotics administration during last trimester of pregnancy is associated with atopic dermatitis \u2013 a cross-sectional study"],"prefix":"10.2478","volume":"58","author":[{"given":"Mihaela","family":"Panduru","sequence":"first","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy of Bucharest , Bucharest , Romania"},{"name":"Colentina Clinical Hospital , Bucharest , Romania"},{"name":"Medlife Grivita Hyperclinic, Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina Mihaela","family":"Epure","sequence":"additional","affiliation":[{"name":"\u201cAlessandrescu-Rusescu\u201d National Institute for Mother and Child Health , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brindusa","family":"Cimpoca","sequence":"additional","affiliation":[{"name":"St. Pantelimon Emergency Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Cozma","sequence":"additional","affiliation":[{"name":"\u201cFloreasca\u201d Emergency Clinical Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitta Ana","family":"Giuca","sequence":"additional","affiliation":[{"name":"Constanta County Emergency Hospital , Constanta , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Pop","sequence":"additional","affiliation":[{"name":"\u201cC.C. Iliescu\u201d Emergency Institute , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Pop","sequence":"additional","affiliation":[{"name":"Emergency University Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa Georgiana","family":"Simon","sequence":"additional","affiliation":[{"name":"Colentina Clinical Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea","family":"Robu","sequence":"additional","affiliation":[{"name":"\u201cC.C. Iliescu\u201d Emergency Institute , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolae Mircea","family":"Panduru","sequence":"additional","affiliation":[{"name":"Medlife Grivita Hyperclinic, Bucharest , Romania"},{"name":"Medicare Healthcare Concept, Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"2026042915234633637_j_rjim-2020-0006_ref_001_w2aab3b7c14b1b6b1ab1ab1Aa","unstructured":"1. BANTZ S.K., ZHU Z., ZHENG T., The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma, J. Clin. Cell. Immunol., 2014, 5(2):202."},{"key":"2026042915234633637_j_rjim-2020-0006_ref_002_w2aab3b7c14b1b6b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. FLOHR C., PASCOE D., WILLIAMS H.C., Atopic dermatitis and the \u2018hygiene hypothesis\u2019: too clean to be true?, Br. J. 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SARIACHVILI M., DROSTE J., DOM S., WIERINGA M., VELLINGA A., HAGENDORENS M. et al., Is breast feeding a risk factor for eczema during the first year of life?, Pediatr. Allergy Immunol., 2007, 18(5):410\u2013417.10.1111\/j.1399-3038.2007.00543.x","DOI":"10.1111\/j.1399-3038.2007.00543.x"},{"key":"2026042915234633637_j_rjim-2020-0006_ref_017_w2aab3b7c14b1b6b1ab1ac17Aa","doi-asserted-by":"crossref","unstructured":"17. JEDRYCHOWSKI W., GALAS A., WHYATT R., PERERA F., The prenatal use of antibiotics and the development of allergic disease in one year old infants. A preliminary study, Int. J. Occup. Med. Environ. Health, 2006, 19(1):70\u201376.10.2478\/v10001-006-0010-0","DOI":"10.2478\/v10001-006-0010-0"},{"key":"2026042915234633637_j_rjim-2020-0006_ref_018_w2aab3b7c14b1b6b1ab1ac18Aa","doi-asserted-by":"crossref","unstructured":"18. 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