{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:46:29Z","timestamp":1777776389007,"version":"3.51.4"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background and aims.<\/jats:bold>\n                    The incidence of Barrett\u2019s Esophagus (BE) is increasing worldwide, thus diagnosis is becoming a major key of interest in preventing esophageal adenocarcinoma. Because the status of BE in Romania is unclear, we performed a narrative review to comprehensively evaluate all published articles on BE from Romania.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods.<\/jats:bold>\n                    We conducted a systematic literature search of PubMed data base and of all Romanian medical journals. The abstracts and the titles of the identified studies were reviewed to exclude the studies that did not answer the search question. In addition we performed a manual search to identify articles on this topic published earlier in local journals or not indexed on internet.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    A total of 17 articles were found. 8 studies and 9 reviews were identified, with a total of 8,829 participants enrolled. The results showed that the median age ranges between 54\u201359 years, with a predominance for male sex, the main risk factors, such as gastroesophageal reflux disease, obesity, smoking, hiatal hernia, are also present in Romania and infection with H. pylori has a protective effect. The diagnosis of Barrett\u2019s esophagus in Romania is established in agreement with international guidelines.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    There are not many publications on BE in Romania. However the data in this country are similar to those reported in other countries. The management is carried out according to standard guidelines. Diagnosing BE relies on endoscopic techniques and classification systems. Risk factors such as gastroesophageal reflux, hiatal hernia, obesity and Helicobacter pylori are considered in Romanian articles. More studies are welcome on this matter in our country.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2020-0007","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T10:30:31Z","timestamp":1590489031000},"page":"111-118","source":"Crossref","is-referenced-by-count":0,"title":["Barrett\u2019s Esophagus in Romania: what do we know?"],"prefix":"10.2478","volume":"58","author":[{"given":"Claudia","family":"Piloiu","sequence":"first","affiliation":[{"name":"2nd Dept. of Internal Medicine , Iuliu Hatieganu University of Medicine and Pharmacy , Cluj-Napoca , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan L.","family":"Dumitrascu","sequence":"additional","affiliation":[{"name":"2nd Dept. of Internal Medicine , Iuliu Hatieganu University of Medicine and Pharmacy , Cluj-Napoca , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"2026042914163651771_j_rjim-2020-0007_ref_001_w2aab3b7b2b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. SPECHLER SJ. Barrett\u2019s esophagus and esophageal adenocarcinoma: pathogenesis, diagnosis and therapy. Med Clin North Am 2002; 86(6):1423\u201345.10.1016\/S0025-7125(02)00082-2","DOI":"10.1016\/S0025-7125(02)00082-2"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_002_w2aab3b7b2b1b6b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. SHLAHEEN N, RANSOHOFF DF. Gastroesophageal reflux, Barrett esophagus and esophageal cancer: scientific review. Jama. 2002; 287(15):1972\u20131981.10.1001\/jama.287.15.1972","DOI":"10.1001\/jama.287.15.1972"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_003_w2aab3b7b2b1b6b1ab1ab3Aa","unstructured":"3. BARR H. KENDALL C, BAZANT-HEGEMARK F, MOAYYEDI P, SHETTY G, STONE N. Endoscopic screening and surveillance for Barrett\u2019s esophagus clinical implications. Med Gen Med 2006; 8:88."},{"key":"2026042914163651771_j_rjim-2020-0007_ref_004_w2aab3b7b2b1b6b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. 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Practica Medicala, Vol. VII, No 1(25), 2012."},{"key":"2026042914163651771_j_rjim-2020-0007_ref_010_w2aab3b7b2b1b6b1ab1ac10Aa","unstructured":"10. PASCARENCO O, DOBRU D, BOERIU A, BRUSNIC O, ONISOR D, STOIAN M et al. The importance of magnification chromoendoscopy with methylene blue in detecting specialized intestinal metaplasia in short segment Barrett\u2019s esophagus. HVM Bioflux 4(1):40\u201344."},{"key":"2026042914163651771_j_rjim-2020-0007_ref_011_w2aab3b7b2b1b6b1ab1ac11Aa","doi-asserted-by":"crossref","unstructured":"11. PASCARENCO O, BOERIU A, MOCAN S, PASCARENCO G, DRASOVEANU S, GALEANU M ET AL. Barrett\u2019s Esophagus and intestinal metaplasia of gastric cardia: prevalence, clinical, endoscopic and histological features. J Gastrointest Liver Dis. 2014, Vol. 23, No 1:19\u201325.10.15403\/jgld-1274","DOI":"10.15403\/jgld-1274"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_012_w2aab3b7b2b1b6b1ab1ac12Aa","doi-asserted-by":"crossref","unstructured":"12. PASCARENCO O, COROS MF, PASCARENCO G, BOERIU A, DRASOVEAN S, ONISOR D et al. A preliminary feasibility study: narrow-band imaging targeted versus standard white light endoscopy non-targeted biopsies in a surveillance Barrett\u2019s population. Digestive and Liver dis, 2016.10.1016\/j.dld.2016.04.017","DOI":"10.1016\/j.dld.2016.04.017"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_013_w2aab3b7b2b1b6b1ab1ac13Aa","unstructured":"13. GINDEA C, BIRLA R, HOARA P, CARAGUL A, CONSTANTINIU S. Barrett Esophagus: history, definition and etiopathogeny. Journal of Medicine and Life Vol. 7, Special Issue 3, 2014."},{"key":"2026042914163651771_j_rjim-2020-0007_ref_014_w2aab3b7b2b1b6b1ab1ac14Aa","unstructured":"14. PASCU O. Boala de reflux gastroesofagian. Esen\u0163ialul \u00een Gastroenterologie \u015fi Hepatologie. Ed Na\u0163ional Buc 2003:4."},{"key":"2026042914163651771_j_rjim-2020-0007_ref_015_w2aab3b7b2b1b6b1ab1ac15Aa","unstructured":"15. PASCU O. Tratamentul bolii de reflux gastro-esofagian. Br Med J (ed. ro) 2002; 7:308\u2013312."},{"key":"2026042914163651771_j_rjim-2020-0007_ref_016_w2aab3b7b2b1b6b1ab1ac16Aa","unstructured":"16. PASCU O, LENCU M. Barrett\u2019s Esophagus. Rom J. Gastroenterol. 2004; 13(3):219\u201322."},{"key":"2026042914163651771_j_rjim-2020-0007_ref_017_w2aab3b7b2b1b6b1ab1ac17Aa","doi-asserted-by":"crossref","unstructured":"17. TANTAU M, LASZLO M, TANTA A. Barrett\u2019s Esophagus-state of the art. Chirurgia (Bucur) 2018; 113:46\u201360.10.21614\/chirurgia.113.1.46","DOI":"10.21614\/chirurgia.113.1.46"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_018_w2aab3b7b2b1b6b1ab1ac18Aa","doi-asserted-by":"crossref","unstructured":"18. IRELAND CJ, THOMPSON SK, LAWS TA, ESTERMAN A. Risk factors for Barrett\u2019s esophagus: a scoping review. Cancer Causes Control 2016; 27(3):301\u201323.10.1007\/s10552-015-0710-5","DOI":"10.1007\/s10552-015-0710-5"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_019_w2aab3b7b2b1b6b1ab1ac19Aa","doi-asserted-by":"crossref","unstructured":"19. ELOUBEIDI M.A, PROVENZALE D, Clinical and demographic predisctors of Barrett\u2019s esophagus among paients with gastroesophageal reflux disease: a multivariable analysis in veterans. J Clin Gastroenterol 2001; 33:306\u2013309.10.1097\/00004836-200110000-00010","DOI":"10.1097\/00004836-200110000-00010"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_020_w2aab3b7b2b1b6b1ab1ac20Aa","doi-asserted-by":"crossref","unstructured":"20. WESTHOFF B, BROTZE S, WESTON A, MCELHINNEY C, CHERIAN R, MAYO M.S, ET AL. The frequency of Barrett\u2019sesophagus in high-risk patients with chronic GERD. Gastrointest Endosc 2005; 61(2):226\u201331.10.1016\/S0016-5107(04)02589-1","DOI":"10.1016\/S0016-5107(04)02589-1"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_021_w2aab3b7b2b1b6b1ab1ac21Aa","doi-asserted-by":"crossref","unstructured":"21. ANDRICI J, TIO M, COX MR, ESLIK GD. Hiatal hernia and the risk of Barrett\u2019s esophagus. J Gastroenterol Hepatol. 2013; 28(3):415\u201331.10.1111\/j.1440-1746.2012.07199.x22694245","DOI":"10.1111\/j.1440-1746.2012.07199.x"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_022_w2aab3b7b2b1b6b1ab1ac22Aa","doi-asserted-by":"crossref","unstructured":"22. GRAHAM DY, YAMAOKA Y. H. pylori and cagA: relationships with gastric cancer, duodenal cancer and reflux esophagitis and its complications. Helicobacter 1998; 3:145\u201351.10.1046\/j.1523-5378.1998.08031.x9731983","DOI":"10.1046\/j.1523-5378.1998.08031.x"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_023_w2aab3b7b2b1b6b1ab1ac23Aa","doi-asserted-by":"crossref","unstructured":"23. TULASSAY Z, STOLTE M, ENGSTRAND L, BUTRUK E, MALFERHEINER P, DITE P ET AL. Twelve-month endoscopic and histological analysis following proton-pump inhibitor-based triple therapy in Helicobacter pylori-positive patients with gastric ulcers. Scand J Gastroenterol 2010; 45:1048\u20131058.10.3109\/0036552090357573720509752","DOI":"10.3109\/00365520903575737"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_024_w2aab3b7b2b1b6b1ab1ac24Aa","doi-asserted-by":"crossref","unstructured":"24. SHARMA P, DENT J, ARMSTRONG D, BERGMAN JJ, GLOSSNER L, HOSHIHARA Y ET AL. The development and validation of an endoscopic grading system for Barrett\u2019s esophagus: the Prague C&M criteria. Gatroenterology 2006; 131(5):1392.10.1053\/j.gastro.2006.08.03217101315","DOI":"10.1053\/j.gastro.2006.08.032"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_025_w2aab3b7b2b1b6b1ab1ac25Aa","doi-asserted-by":"crossref","unstructured":"25. BALDAQUE SF, MARQUES M, LUNET N, THEMUDO G, GODA K, TOTH E ET AL. Endoscopic assessment and grading of Barrett\u2019s esophagus using magnification endoscopy and narrow band imaging: impact of structured learning and experience of the accuracy of the Amsterdam classification system. Scandinavian J Gastroenterol 2012; 48(2):160\u2013167.10.3109\/00365521.2012.74639223215965","DOI":"10.3109\/00365521.2012.746392"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_026_w2aab3b7b2b1b6b1ab1ac26Aa","doi-asserted-by":"crossref","unstructured":"26. SHARMA P, BENSAL A, MARTHUR S, WANI S, CHERIAN R, MCGREGOR D ET AL. The utility of a novel narrow band imaging endoscopy system in patients with Barrett\u2019s esophagus. Gastrintest Endosc 2006; 64:167\u201375.10.1016\/j.gie.2005.10.04416860063","DOI":"10.1016\/j.gie.2005.10.044"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_027_w2aab3b7b2b1b6b1ab1ac27Aa","doi-asserted-by":"crossref","unstructured":"27. SCHEMPLER R, RIDDELL R, KATO Y, BORCHARD F, COOPER H, DAWSEY S et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut 2000; 47(2):251\u2013255.10.1136\/gut.47.2.251172801810896917","DOI":"10.1136\/gut.47.2.251"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_028_w2aab3b7b2b1b6b1ab1ac28Aa","doi-asserted-by":"crossref","unstructured":"28. BOERIU A, BRUSNIC O, ONISOR D, PASCARENCO O, BOERIU C, DOBRU D. The usefulness of white light endoscopy, narrow band imaging and magnification for the optimization of diagnosis in Barrettt\u2019s esophagus. Acta Medica Marisiensis 2014; 60(6):244\u2013248.10.1515\/amma-2015-0002","DOI":"10.1515\/amma-2015-0002"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_029_w2aab3b7b2b1b6b1ab1ac29Aa","doi-asserted-by":"crossref","unstructured":"29. FITZGERALD RD, DI PIETRO M, RAGAUNATH K, ANG Y, KANG JY, WATSON P et al. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett\u2019s esophagus. Gut 2014; 63(1):7\u20134210.1136\/gutjnl-2013-30537224165758","DOI":"10.1136\/gutjnl-2013-305372"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_030_w2aab3b7b2b1b6b1ab1ac30Aa","doi-asserted-by":"crossref","unstructured":"30. ENDO T, AWAKAWA T, TAKAHASHI H, ITOH F, YAMASHITA K, SASAKI S et al. Classification of Barrett\u2019s epithelium by magnifying endoscopy. Gastointest Endosc 2002; 55(6):641\u20137.10.1067\/mge.2002.12342011979244","DOI":"10.1067\/mge.2002.123420"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_031_w2aab3b7b2b1b6b1ab1ac31Aa","doi-asserted-by":"crossref","unstructured":"31. TANTAU M., LASZLO M, TANTA A. Barrett\u2019s Esophagus-state of the art. Chirurgia (Bucur) 2018; 113:46\u201360.10.21614\/chirurgia.113.1.4629509531","DOI":"10.21614\/chirurgia.113.1.46"},{"key":"2026042914163651771_j_rjim-2020-0007_ref_032_w2aab3b7b2b1b6b1ab1ac32Aa","doi-asserted-by":"crossref","unstructured":"32. BAZIN C, BENEZECH A, ALESSANDRINI M, GRIMAUD JC, VITTON V. Esophageal motor disorders are a strong independent associated factor of Barret\u2019s esophagus. 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