{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:37:00Z","timestamp":1777775820941,"version":"3.51.4"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background.<\/jats:bold>\n                    Systemic sclerosis (Ssc) is an autoimmune disease characterized by graduate cutaneous and tissue fibrosis development and irreversible fibroproliferative vascular changes.\n                  <\/jats:p>\n                  <jats:p>The aim of the current systematic review was to update the list of proteomic candidate biomarkers identified from Ssc samples with mass spectrometry techniques.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods.<\/jats:bold>\n                    Medline and Scopus databases were searched on 1\n                    <jats:sup>st<\/jats:sup>\n                    September 2020. Relevant articles were searched from March 2014 until September 2020. Two independent reviewers evaluated the retrieved articles.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    From a total of 97 articles, 9 articles were included in the final analysis summarizing 539 candidate proteomic biomarkers from various samples from Ssc patients (a larger number compared to the previous systematic review). Most biomarkers were identified from cutaneous biopsies. Only 5 articles included a validation step of the findings with only 13 biomarkers being validated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    Although many candidate biomarkers were additionally identified, independent validation studies are needed in order to evaluate the importance of these biomarkers for Ssc patients.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2020-0037","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T15:53:39Z","timestamp":1606751619000},"page":"101-111","source":"Crossref","is-referenced-by-count":2,"title":["Candidate proteomic biomarkers in systemic sclerosis discovered using mass-spectrometry: an update of a systematic review (2014\u20132020)"],"prefix":"10.2478","volume":"59","author":[{"given":"Paul","family":"B\u0103l\u0103nescu","sequence":"first","affiliation":[{"name":"University of Medicine and Pharmacy Carol Davila , Internal Medicine Chair , Bucharest , Romania"},{"name":"Clinical Immunology Laboratory CDPC , Colentina Clinical Hospital , Bucharest , Romania"},{"name":"Clinical Research Unit RECIF (Reseau d\u2019Epidemiologie Clinique International Francophone) , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"B\u0103l\u0103nescu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Carol Davila , Pediatrics Chair , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"B\u0103l\u0103nescu","sequence":"additional","affiliation":[{"name":"Clinical Immunology Laboratory CDPC , Colentina Clinical Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"B\u0103icu\u015f","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Carol Davila , Internal Medicine Chair , Bucharest , Romania"},{"name":"Clinical Immunology Laboratory CDPC , Colentina Clinical Hospital , Bucharest , Romania"},{"name":"Clinical Research Unit RECIF (Reseau d\u2019Epidemiologie Clinique International Francophone) , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"2026042914151160241_j_rjim-2020-0037_ref_001_w2aab3b7b4b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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N Engl J Med. 2014 Jan 30; 370(5):433\u201343.10.1056\/NEJMoa1114576404046624350901","DOI":"10.1056\/NEJMoa1114576"},{"key":"2026042914151160241_j_rjim-2020-0037_ref_020_w2aab3b7b4b1b6b1ab1ac20Aa","doi-asserted-by":"crossref","unstructured":"20. LUO JY, LIU X, JIANG M, ZHAO HP, ZHAO JJ. Oxidative stress markers in blood in systemic sclerosis: A meta-analysis. Mod Rheumatol. 2017; 27(2):306\u2013314.10.1080\/14397595.2016.120651027425641","DOI":"10.1080\/14397595.2016.1206510"},{"key":"2026042914151160241_j_rjim-2020-0037_ref_021_w2aab3b7b4b1b6b1ab1ac21Aa","doi-asserted-by":"crossref","unstructured":"21. LEPARA Z, LEPARA O, FAJKI\u0106 A, REBI\u0106 D, ALI\u0106 J, SPAHOVI\u0106 H. Serum malondialdehyde (MDA) level as a potential biomarker of cancer progression for patients with bladder cancer. 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