{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:36:20Z","timestamp":1780598180444,"version":"3.54.1"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Upper digestive tract endoscopy remains the gold-standard for detecting esophageal or gastric varices and assessment of bleeding risk, but this method is invasive. The aim of the study was to identify non-invasive factors that could be incorporated into an algorithm for estimating the risk of variceal bleeding.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods.<\/jats:bold>\n                    A prospective study was performed on 130 cirrhotic patients. Tests were performed on all patients which included liver enzymes, complete blood count and coagulation parameters, abdominal ultrasound, elastography of both the liver and the spleen. Upper gastrointestinal endoscopy was performed in all patients included in the study and the results were classified, in accordance with Baveno VI into 2 outcome groups: Group 1 \u2013 patients with low bleeding risk and Group 2 \u2013 patients with varices needing treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    The study lot (130 patients) was divided into: Group I (low bleeding risk \u2013 102 patients), and Group II (high bleeding risk \u2013 28 patients). Parameters found to have significant differences in univariate analysis were transaminases, platelet count, spleen size, INR, portal vein diameter and both liver and spleen elastography. Calculating AUROC for each parameter identifies spleen elastography as having the best result, followed by INR, AST and platelet count. Liver elastography had the worst AUROC. Independent variables identified by logistic regression included spleen elastography, INR, platelet count, spleen diameter, ALT, age, and gender.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    Spleen stiffness is the best single parameter predicting the presence of high-risk esophageal varices.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2021-0001","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T05:52:33Z","timestamp":1617688353000},"page":"194-200","source":"Crossref","is-referenced-by-count":3,"title":["Non-invasive laboratory, imaging and elastography markers in predicting varices with high risk of bleeding in cirrhotic patients"],"prefix":"10.2478","volume":"59","author":[{"given":"Ana","family":"Petrisor","sequence":"first","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy , Gastroenterology and Internal Medicine II Clinic \u2013 University Emergency Hospital Bucharest , Bucharest , Romania"},{"name":"University Emergency Hospital Bucharest , Gastroenterology Department Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Alexandra","family":"Stanescu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy , Family Medicine Department , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Raluca","family":"Papacocea","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy , Physiology Department 1 , Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Panaitescu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy , Medical Informatics and Biostatistics , Bucharest , Romania"},{"name":"Carol Davila University of Medicine and Pharmacy , Intensive Computing and Computational Medicine Centre , Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan","family":"Peagu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy , Gastroenterology and Internal Medicine II Clinic \u2013 University Emergency Hospital Bucharest , Bucharest , Romania"},{"name":"University Emergency Hospital Bucharest , Gastroenterology Department Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru Constantin","family":"Moldoveanu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy , Gastroenterology and Internal Medicine II Clinic \u2013 University Emergency Hospital Bucharest , Bucharest , Romania"},{"name":"University Emergency Hospital Bucharest , Gastroenterology Department Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fierbinteanu-Braticevici","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy , Gastroenterology and Internal Medicine II Clinic \u2013 University Emergency Hospital Bucharest , Bucharest , Romania"},{"name":"University Emergency Hospital Bucharest , Gastroenterology Department Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"2026042914160957625_j_rjim-2021-0001_ref_001_w2aab3b7c22b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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BASILI S, RAPARELLI V, NAPOLEONE L, TALERICO G, CORAZZA GR, PERTICONE F, SACERDOTI D, ANDRIULLI A, LICATA A, PIETRANGELO A, PICARDI A, RAIMONDO G, VIOLI F. Platelet Count Does Not Predict Bleeding in Cirrhotic Patients: Results from the PRO-LIVER Study. Am J Gastroenterol. 2018 Mar; 113(3):368\u201375. doi: 10.1038\/ajg. 2017.457.","DOI":"10.1038\/ajg.2017.457"},{"key":"2026042914160957625_j_rjim-2021-0001_ref_029_w2aab3b7c22b1b6b1ab1ac29Aa","doi-asserted-by":"crossref","unstructured":"29. O\u2019LEARY JG, GREENBERG CS, PATTON HM, CALDWELL SH. AGA Clinical Practice Update: Coagulation in Cirrhosis. Gastroenterology. 2019 Jul; 157(1):34\u201343.e1. doi: 10.1053\/j.gastro.2019.03.070.10.1053\/j.gastro.2019.03.07030986390","DOI":"10.1053\/j.gastro.2019.03.070"},{"key":"2026042914160957625_j_rjim-2021-0001_ref_030_w2aab3b7c22b1b6b1ab1ac30Aa","doi-asserted-by":"crossref","unstructured":"30. KRAJA B, MONE I, AKSHIJA I, KO\u00c7OLLARI A, PRIFTI S, BURAZERI G. 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