{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:12:19Z","timestamp":1777777939542,"version":"3.51.4"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Hemodialysis (HD) patients have higher mortality rate than the general population. Recent studies indicate a significant role of non-cardiovascular risk factors in for mortality in HD patients. Leptin is protein hormone and may indicate malnutrition in HD patients. Its role in mortality in these patients is being examined. This study aimed to investigate the correlation between serum leptin levels and non-cardiovascular risk factors and relationship between leptin level and mortality in HD patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods.<\/jats:bold>\n                    The prospective study included 93 patients on maintenance HD and follow-up period was 12 months. We measured leptin level and evaluated non-cardiovascular risk factors: nutritional status, anemia, volemia, parameters of mineral and bone disorder.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    Out of 93 patients 9 died during study and 1 underwent kidney transplantation. Malnutrition and hypervolemia were two main non-cardiovascular risk factors among deceased subjects. Leptin showed a significant direct correlation with nutritional BMI (r = 0.72,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), fat tissue index (r = 0.74,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) and statistically significant inverse correlation with leantissue index (r = -0.349,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) and inverse correlation with volemic parameters (overhydration \/ extracellular water ratio (r = -0.38,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), but no association with anemia and mineral bone parameters was observed. Elevated leptin levels were associated with better survival. However, no statistically significant difference in survival rates was observed between the study groups (Log-Rank\n                    <jats:italic>P<\/jats:italic>\n                    =0.214, Breslow\n                    <jats:italic>P<\/jats:italic>\n                    =0.211, Tarone-Ware\n                    <jats:italic>P<\/jats:italic>\n                    =0.212).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    Deceased patients had significantly lower leptin values. Leptin was associated with two non-cardiovascular risk factors for mortality: malnutrition and hypervolemia.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2021-0002","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T05:58:52Z","timestamp":1617688732000},"page":"187-193","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between serum leptin levels, non-cardiovascular risk factors and mortality in hemodialysis patients"],"prefix":"10.2478","volume":"59","author":[{"given":"Ivona","family":"Risovic","sequence":"first","affiliation":[{"name":"Department of Endocrinology , University Clinical Center of the Republic of Srpska , 12 babies nn, Banja Luka , Bosnia and Herzegovina"},{"name":"Faculty of Medicine , University of Banja Luka , Save Mrkalja 14, Banja Luka , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlastimir","family":"Vlatkovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine , University of Banja Luka , Save Mrkalja 14, Banja Luka , Bosnia and Herzegovina"},{"name":"Department of Nephrology , University Clinical Center of the Republic of Srpska , 12 babies nn, Banja Luka , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snjezana","family":"Popovic-Pejicic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , University Clinical Center of the Republic of Srpska , 12 babies nn, Banja Luka , Bosnia and Herzegovina"},{"name":"Faculty of Medicine , University of Banja Luka , Save Mrkalja 14, Banja Luka , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrijela","family":"Male\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , University Clinical Center of the Republic of Srpska , 12 babies nn, Banja Luka , Bosnia and Herzegovina"},{"name":"Faculty of Medicine , University of Banja Luka , Save Mrkalja 14, Banja Luka , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"2026042915235592791_j_rjim-2021-0002_ref_001_w2aab3b7c24b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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Do i: 10.1155\/2013\/518945.10.1155\/2013\/518945385771824347799","DOI":"10.1155\/2013\/518945"},{"key":"2026042915235592791_j_rjim-2021-0002_ref_004_w2aab3b7c24b1b6b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. PALMER SC,RUOSPO M, CAMPBELL KL, GARCIA ALERSEN V, SAGLIMBENE V et al. Nutrition and dietary, intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD,a prospective multinational cohort study. BMJ Open 2015;5:e006897.doi:10.1136\/bmjopen-2014-006897.10.1136\/bmjopen-2014-006897436892225795691","DOI":"10.1136\/bmjopen-2014-006897"},{"key":"2026042915235592791_j_rjim-2021-0002_ref_005_w2aab3b7c24b1b6b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. RISOVI\u0106 I, VLATKOVI\u0106 V, POPOVI\u0106-PEJI\u010cI\u0106 S, TRBOJEVI\u0106-STANKOVI\u0106 J. The relationship between leptin level, inflammation and volume status in maintenance hemodialysis patient. 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PMID: 25001138."}],"container-title":["Romanian Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/rjim-2021-0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:12:58Z","timestamp":1777489978000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/rjim-2021-0002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,8]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,5,8]]},"published-print":{"date-parts":[[2021,6,1]]}},"alternative-id":["10.2478\/rjim-2021-0002"],"URL":"https:\/\/doi.org\/10.2478\/rjim-2021-0002","relation":{},"ISSN":["2501-062X"],"issn-type":[{"value":"2501-062X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,8]]}}}