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The underlying pathophysiology is complex, involving mitochondrial dysfunction, increased protein breakdown and muscle inexcitability. Sepsis induced myopathy is characterized by several electrophysiological and histopathological abnormalities of the muscle, also has clinical consequences such as flaccid weakness and failure to wean from ventilator. In order to reach definite diagnosis, clinical assessment, electrophysiological studies and muscle biopsy must be performed, which can be challenging in daily practice. Ultrasonography as a screening tool can be a promising alternative, especially in the ICU setting. Sepsis and mechanical ventilation have additive effects leading to diaphragm dysfunction thus complicating the patient\u2019s clinical course and recovery. Here, we summarize the effects of the septic syndrome on the muscle tissue based on the existing literature.<\/jats:p>","DOI":"10.2478\/rjim-2021-0005","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T06:07:25Z","timestamp":1617689245000},"page":"218-226","source":"Crossref","is-referenced-by-count":3,"title":["Sepsis and the muscle tissue. A narrative review"],"prefix":"10.2478","volume":"59","author":[{"given":"Eleousa","family":"Oikonomou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine , University Hospital of Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Themistoklis","family":"Paraskevas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , University Hospital of Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Velissaris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , University Hospital of Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"2026042914164401011_j_rjim-2021-0005_ref_001","doi-asserted-by":"crossref","unstructured":"1. BORGES RC, CARVALHO CRF, COLOMBO AS, DA SILVA BORGES MP, SORIANO FG. 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