{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:24:04Z","timestamp":1777775044890,"version":"3.51.4"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:00:00Z","timestamp":1637366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Lichen planus (LP) is a mucocutaneous T-cell mediated disorder of unknown etiology. There is growing evidence that oxidative stress is an important player in the pathogenesis of LP. Therefore, we have investigated oxidative stress markers in LP and the influence of hepatitis C virus (HCV) infection, a frequently associated condition, on oxidative stress in LP patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method.<\/jats:bold>\n                    We have determined the serum levels of 4- hydroxynonenal (4-HNE) and symmetric dimethylarginine (SDMA), as markers of oxidative stress, and total antioxidant capacity (TAC), as a marker of the antioxidant defence, in 4 groups: group A \u2013 HCV positive patients with LP (n=12), group B \u2013 HCV positive patients without LP (n=12), group C \u2013 HCV negative patients with LP (n=31) and group D \u2013 control group (n=26).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    In LP patients, we have identified an increased level of lipid peroxidation (4-HNE \u2013 group A \u2013 8.41\u00b11.11 \u03bcg\/mL, group B - 7.97\u00b12.17 \u03bcg\/mL, group C \u2013 7.81\u00b11.96 \u03bcg\/mL and group D \u2013 6.15\u00b11.17 \u03bcg\/mL) and alterations in arginine methylation (SDMA \u2013 group A \u2013 1.10\u00b10.24 \u03bcmol\/L, group B \u2013 1.03\u00b10.16 \u03bcmol\/L, group C \u2013 0.84\u00b10.19 \u03bcmol\/L and group D \u2013 0.50\u00b10.06 \u03bcmol\/L) associated with a diminished antioxidant defence (TAC \u2013 group A \u2013 234.50\u00b149.96, \u03bcmol\/L group B \u2013 255.83\u00b141.41 \u03bcmol\/L, group C \u2013 269.83\u00b143.33 \u03bcmol\/L and group D \u2013 316.46 \u00b129.33 \u03bcmol\/L), processes augmented by the association with HCV infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    There is an imbalance between oxidants and antioxidants in patients with LP, an imbalance that is augmented by the presence of HCV infection. SDMA could be regarded as a novel biomarker of oxidative stress among these patients. To the best of our knowledge this is the first study to investigate the influence of HCV infection on oxidative stress in LP patients.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2021-0017","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T17:11:36Z","timestamp":1620234696000},"page":"359-368","source":"Crossref","is-referenced-by-count":1,"title":["New markers of oxidative stress in lichen planus and the influence of hepatitis C virus infection \u2013 a pilot study"],"prefix":"10.2478","volume":"59","author":[{"given":"Madalina Irina","family":"Mitran","sequence":"first","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy , 37 Dionisie Lupu, 020021 Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea","family":"Tampa","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy , 37 Dionisie Lupu, 020021 Bucharest , Romania"},{"name":"\u201cVictor Babes\u201d Clinical Hospital for Infectious Diseases , 281 Mihai Bravu, 030303 Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilinca","family":"Nicolae","sequence":"additional","affiliation":[{"name":"\u201cVictor Babes\u201d Clinical Hospital for Infectious Diseases , 281 Mihai Bravu, 030303 Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Iulia","family":"Mitran","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy , 37 Dionisie Lupu, 020021 Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Matei","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy , 37 Dionisie Lupu, 020021 Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona Roxana","family":"Georgescu","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy , 37 Dionisie Lupu, 020021 Bucharest , Romania"},{"name":"\u201cVictor Babes\u201d Clinical Hospital for Infectious Diseases , 281 Mihai Bravu, 030303 Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea Ioan","family":"Popa","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy , 37 Dionisie Lupu, 020021 Bucharest , Romania"},{"name":"\u201cCantacuzino\u201d National Medico-Military Institute for Research and Development , 103 Splaiul Independentei, 050096 , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,11,20]]},"reference":[{"key":"2026042913133011150_j_rjim-2021-0017_ref_001","doi-asserted-by":"crossref","unstructured":"1. 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