{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:38:26Z","timestamp":1777775906267,"version":"3.51.4"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:00:00Z","timestamp":1637366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    (VB), vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and methods.<\/jats:bold>\n                    The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form-36 (SF-36). This study examined the VD, VB, and ferritin levels of the patient and control groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    The VB (240.0 [110.0\u2013394.0] vs 291.0 [210.0\u2013609.0] pg\/ml, p&lt;0.001), VD (12.5 [3.0\u201345.0] vs 20.0 [5.0\u201354.0] ng\/ml, p=0.013), and ferritin levels (21.2 [4.0\u201386.0] vs 32.0 [7.1\u2013120.0], ng\/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.015\u20131.058, p&lt;0.001) and VB (OR 1.010, CI 1.002\u20131.018, p=0.010) to be an independent risk factor for FS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not be a risk factor for FS etiopathogenesis.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2021-0022","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T22:37:58Z","timestamp":1623969478000},"page":"384-393","source":"Crossref","is-referenced-by-count":2,"title":["Could ferritin, vitamin B\n                    <sub>12<\/sub>\n                    , and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?"],"prefix":"10.2478","volume":"59","author":[{"given":"Adem","family":"Kucuk","sequence":"first","affiliation":[{"name":"Department of Rheumatology , Necmettin Erbakan University , Konya , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia Aydogan","family":"Baykara","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, School of Medicine , Turgut Ozal University , Malatya , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayca","family":"Tuzcu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine , Adnan Menderes University , Ayd\u0131n , Turkey ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Omma","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine , Numune Education and Research Hospital , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medine Cumhur","family":"Cure","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Private Kucukcekmece Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Cure","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Ota&Jinemed Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunseli Karaca","family":"Acet","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation , Malatya Education and Research Hospital , Malatya , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdal","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation , Malatya Park Private Hospital , Malatya , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,11,20]]},"reference":[{"key":"2026042914151926158_j_rjim-2021-0022_ref_001","doi-asserted-by":"crossref","unstructured":"1. 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