{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:49:31Z","timestamp":1777776571320,"version":"3.51.4"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Thyroid hormones affect the cardiovascular system, but the precise mechanisms of their effects on the development of atherosclerosis are not entirely clear. The relationship between subclinical hypothyroidism, dyslipidemia and carotid atherosclerosis has been widely investigated, but the findings were controversial. The aim of the present study was to determine whether female subjects with subclinical hypothyroidism (SHypo) have increased carotid intima-media thickness (IMT) compared with euthyroid subjects, as well as to examine the association of SHypo, carotid atherosclerosis and dyslipidemia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This research included 100 women aged 30 to 70 years who were divided into two groups: the SHypo group including subjects with signs of subclinical hypothyroidism and the control group of euthyroid subjects. Carotid IMT thickness using B mode ultrasound was determined and its correlation with serum concentrations of fT4, TSH, CRP, and lipid profile including small dense LDL (sdLDL) was analysed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Subjects with SHypo had significantly increased carotid IMT (IMT \u2265 75th centile) in all three measured segments of the right (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001) and the left (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001) carotid artery compared to the control group, with a significantly more frequent appearance of plaque (25% vs. 9%;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.05). Significant positive correlations were found between higher TSH and higher IMT values. Increased age, LDL cholesterol, and TSH predicted thickening of the carotid artery IMT.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    It is important to screen people showing early, subclinical signs of thyroid gland dysfunction due to its impact on carotid atherosclerosis development.\n                  <\/jats:p>","DOI":"10.2478\/rjim-2021-0028","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T19:21:54Z","timestamp":1627154514000},"page":"24-33","source":"Crossref","is-referenced-by-count":6,"title":["The role of thyroid hormones in carotid arterial wall remodeling in women"],"prefix":"10.2478","volume":"60","author":[{"given":"Maida Seferovic","family":"Saric","sequence":"first","affiliation":[{"name":"Department of Neurology , Zabok General Hospital and Hospital of Croatian Veterans , Bracak 8 , Zabok , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miljenka-Jelena","family":"Jurasic","sequence":"additional","affiliation":[{"name":"Department of Neurology , Sestre Milosrdnice University Hospital Center , Vinogradska cesta 29 , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrvoje","family":"Budincevic","sequence":"additional","affiliation":[{"name":"Department of Neurology , University Hospital Sveti Duh , Sveti Duh 64 , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Epidemiology and Medical Informatics , University of Zagreb Andrija Stampar School of Public Health , Johna Davidsona Rockfellera 4 , , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojana","family":"Kranjcec","sequence":"additional","affiliation":[{"name":"Medical and Biochemical Laboratory , Zabok General Hospital and Hospital of Croatian Veterans , Bracak 8 , Zabok , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Kovacic","sequence":"additional","affiliation":[{"name":"Department of Neurology , Zabok General Hospital and Hospital of Croatian Veterans , Bracak 8 , Zabok , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Leskovar","sequence":"additional","affiliation":[{"name":"Department of Neurology , Zabok General Hospital and Hospital of Croatian Veterans , Bracak 8 , Zabok , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vida","family":"Demarin","sequence":"additional","affiliation":[{"name":"Croatian Academy of Sciences and Arts , Trg Nikole Subica Zrinskog 11 , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"2026042914165054495_j_rjim-2021-0028_ref_001","unstructured":"1. WILSON GR., CURRY RW. Subclinical Thyroid Disease. Am Fam Physician. 2005;72(8):1517\u20131524."},{"key":"2026042914165054495_j_rjim-2021-0028_ref_002","unstructured":"2. MALEKI N., KAZEROUNI F., HEDAYATI M., RAHIMIPOUR A., PARHAM M. Subclinical Hypothyroidism and the Alterations of Lipid Profile as a Cardiovascular Risk Factor. J Paramed Sci. 2015;6(4):2008\u20134978."},{"key":"2026042914165054495_j_rjim-2021-0028_ref_003","doi-asserted-by":"crossref","unstructured":"3. RIZOS CV., ELISAF MS., LIBEROPOULUS EN. Effects of Thyroid Dysfunction on Lipid Profile. Open Cardiovasc Med J. 2011;5:76\u201384.10.2174\/1874192401105010076310952721660244","DOI":"10.2174\/1874192401105010076"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_004","doi-asserted-by":"crossref","unstructured":"4. TOUBOUL PJ., ELBAZ A., KOLLER C., LUCAS C., ADRAI V., CHEDRU F., et.al. Common carotid artery intima-media thickness and brain infarction. Circulation. 2000;102:313\u2013318.10.1161\/01.CIR.102.3.31310899095","DOI":"10.1161\/01.CIR.102.3.313"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_005","doi-asserted-by":"crossref","unstructured":"5. WEBER F. Risk factors for subclinical carotid atherosclerosis in healthy men. Neurology. 2002;59:524\u2013528.10.1212\/WNL.59.4.524","DOI":"10.1212\/WNL.59.4.524"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_006","unstructured":"6. DEMARIN V., LOVREN\u010cI\u0106-HUZJAN A. Neurosonologija. Zagreb: \u0160kolska knjiga; 2009. p. 88\u201392."},{"key":"2026042914165054495_j_rjim-2021-0028_ref_007","doi-asserted-by":"crossref","unstructured":"7. HOWARD G., SHARRETT AR., HEISS G., EVANS GW., CHAMBLESS LE., RILEY WA., ET AL. Carotid intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC investigators. Stroke. 1993;24:1297\u20131304.10.1161\/01.STR.24.9.12978362421","DOI":"10.1161\/01.STR.24.9.1297"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_008","unstructured":"8. SOLTER M. Bolesti \u0161titnja\u010de \u2013 klini\u010dka tireoidologija. Zagreb: Medicinska naklada; 2007."},{"key":"2026042914165054495_j_rjim-2021-0028_ref_009","unstructured":"9. KARAGIANNIS AKA. and NAKOUTI T. The Role of Carotid Intima Media Thickness in Subclinical Hypothyroidism. A Systematic Review. Austin J Obes & Metab Synd. 2020;4(2): 1020."},{"key":"2026042914165054495_j_rjim-2021-0028_ref_010","doi-asserted-by":"crossref","unstructured":"10. GONG N., GAO C., CHEN X., FANG Y., TIAN L. Endothelial Function in Patients with Subclinical Hypothyroidism: A Meta-Analysis. Horm Metab Res. 2019;51(11):691\u2013702.10.1055\/a-1018-956431683338","DOI":"10.1055\/a-1018-9564"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_011","doi-asserted-by":"crossref","unstructured":"11. SEFEROVIC SARIC M., JURASIC MJ., SOVIC S., KRANJCEC B., GLIVETIC T., DEMARIN V. Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C). Rom J Intern Med. 2017;55(3):159\u2013166.10.1515\/rjim-2017-0015","DOI":"10.1515\/rjim-2017-0015"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_012","doi-asserted-by":"crossref","unstructured":"12. TOUBOUL PJ., HENNERICI MG., MEAIRS S., ADAMS H., AMARENCO P., BORNSTEIN N. Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004\u20132006\u20132011). An Update on Behalf of the Advisory Board of the 3rd, 4th and 5th Watching the Risk Symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis. 2012;34(4):290\u2013296.10.1159\/000343145","DOI":"10.1159\/000343145"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_013","doi-asserted-by":"crossref","unstructured":"13. GAO N., ZHANG W., ZHANG YZ., YANG Q., CHEN SH. Carotid intima-media thickness in patients with subclinical hypothyroidism: a meta-analysis. Atherosclerosis. 2013;227(1):18\u201325.10.1016\/j.atherosclerosis.2012.10.07023159101","DOI":"10.1016\/j.atherosclerosis.2012.10.070"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_014","unstructured":"14. LUBOSHITZKY R., HERER P. Cardiovascular risk factors in middle-aged women with subclinical hypothyroidism. Neuroendocrinol Lett. 2004;85:1049\u20131053."},{"key":"2026042914165054495_j_rjim-2021-0028_ref_015","doi-asserted-by":"crossref","unstructured":"15. VELKOSKA NAKOVA V., BOSEVSKI M., DIMITROVSKI C., KRSTEVSKA B. Subclinical hypothyroidism and risk to carotid atherosclerosis. Arq Bras Endocrinol Metabol. 2011;55(7):475\u2013480.10.1590\/S0004-2730201100070000722147096","DOI":"10.1590\/S0004-27302011000700007"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_016","doi-asserted-by":"crossref","unstructured":"16. PEIXOTO DE MIRANDA EJF., BITTENCOURT MS., PEREIRA AC., GOULART AC., SANTOS IS., LOTUFO PA. Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Nutr Metab Cardiovasc Dis. 2016;26:915\u2013921.10.1016\/j.numecd.2016.06.00527389191","DOI":"10.1016\/j.numecd.2016.06.005"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_017","doi-asserted-by":"crossref","unstructured":"17. AZIZ M., KANDIMALLA Y., MACHAVARAPU A., SAXENA A., DAS S., YOUNUS A., et al. Effect of Thyroxin Treatment on Carotid Intima-Media Thickness (CIMT) Reduction in Patients with Subclinical Hypothyroidism (SCH): a Meta-Analysis of Clinical Trials. J Atheroscler Thromb. 2017;24(7):643\u2013659.10.5551\/jat.39917551753728566564","DOI":"10.5551\/jat.39917"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_018","doi-asserted-by":"crossref","unstructured":"18. FENG X., ZHAO L., JIANG J., MA W., SHANG X., ZHOU Q., et al. Discriminatory value of carotid artery elasticity changes for the evaluation of thyroid dysfunction in patients with hashimoto\u2019s thyroiditis. J Clin Ultrasound. 2016;44:298\u2013304.10.1002\/jcu.2232826856968","DOI":"10.1002\/jcu.22328"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_019","doi-asserted-by":"crossref","unstructured":"19. ZHOU Y., ZHAO L., WANG T., HONG J., ZHANG J., XU B., et al. Free Triiodothyronine concentrations are inversely associated with elevated carotid intima-media thickness in middle-aged and elderly Chinese population. J Atheroscler Thromb. 2016;23(2):216\u2013224.10.5551\/jat.3033826423715","DOI":"10.5551\/jat.30338"},{"key":"2026042914165054495_j_rjim-2021-0028_ref_020","doi-asserted-by":"crossref","unstructured":"20. SAIF A., MOUSA S., ASSEM M., THARWAT N. and ABDELHAMID A. Endothelial dysfunction and the risk of atherosclerosis in overt and subclinical hypothyroidism. 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