{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:55:58Z","timestamp":1777776958384,"version":"3.51.4"},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Celiac disease is an immune-mediated illness to gluten exposure in genetically susceptible patients. It is characterized by chronic lymphocytic inflammation of the small bowel leading to villous atrophy and its associated complications. The global prevalence of celiac disease is increasing, due in part to improved screening tests and simplified diagnostic criteria. Novel therapies are being developed and include proteolytic enzymes, sequestering agents, and immunotherapies. A strict gluten-free diet, however, remains the mainstay of treatment. In this comprehensive review, we discuss the epidemiology, definitions, diagnosis, and treatment of celiac disease.<\/jats:p>","DOI":"10.2478\/rjim-2022-0002","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T10:23:20Z","timestamp":1643451800000},"page":"93-102","source":"Crossref","is-referenced-by-count":2,"title":["Systematic approach to celiac disease: a comprehensive review for primary providers"],"prefix":"10.2478","volume":"60","author":[{"given":"Pedro","family":"Cort\u00e9s","sequence":"first","affiliation":[{"name":"Division of Community Internal Medicine, Mayo Clinic Jacksonville ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana M","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Community Internal Medicine, Mayo Clinic Jacksonville ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Bi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Jacksonville ,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"2026042915194020295_j_rjim-2022-0002_ref_001","doi-asserted-by":"crossref","unstructured":"1. 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PATERSON B., LAMMERS KM., ARRIETA. MC., FASANO A., MEDDINGS JB. The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment Pharmacol Ther. 2007;26(5):757\u2013766.10.1111\/j.1365-2036.2007.03413.x17697209","DOI":"10.1111\/j.1365-2036.2007.03413.x"},{"key":"2026042915194020295_j_rjim-2022-0002_ref_035","doi-asserted-by":"crossref","unstructured":"35. GOLFEYZ S. Celiac Disease and Fecal Microbiota Transplantation: A New Beginning? Am J Gastroenterol. 2018;113(8):1256.10.1038\/s41395-018-0094-829880966","DOI":"10.1038\/s41395-018-0094-8"},{"key":"2026042915194020295_j_rjim-2022-0002_ref_036","doi-asserted-by":"crossref","unstructured":"36. LEBWOHL B., NOBEL YR., GREEN PHR., BLASER MJ., LUDVIGSSON JF. Risk of Clostridium difficile Infection in Patients With Celiac Disease: A Population-Based Study. 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