{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:45:36Z","timestamp":1777776336377,"version":"3.51.4"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The cortical bone is the most severely affected site in patients with primary hyperparathyroidism (PHPT) and thus, a low bone mineral density (BMD) is predominantly observed in distal forearm. Several studies have investigated potential associations between the weight of the gland and bone mineral loss. In this study, we wanted to investigate the relationship between parathyroid adenoma (PTA) volume and bone mineral loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with a diagnosis of PHPT who were operated at our hospital, and with a histologically proven single PTA were retrospectively analyzed. Z-scores were used as the main variable in our analysis to eliminate the effects of age, sex and gonadal status on BMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Total of 153 patients who met the inclusion criteria were eligible for the study. A significant negative correlation between the PTA volume and z-score for distal third of the radius (DR) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006, r = -0.297) was shown. The cut-off value of gland volume for predicting cortical bone mineral loss was 9043.2 mm\n                      <jats:sup>3<\/jats:sup>\n                      . There was also a significant negative correlation between the 24-hour urine calcium and z-scores for lumbar vertebrae and total hip. A significant negative correlation was found between preoperative 25-hydroxy vitamin D levels and the PTA weight.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As the first study that evaluated any possible association between the volume of a parathyroid adenoma and bone mineral loss in patients with PHPT, we found a significant negative correlation between DR z-scores and resected gland volume. Since the volume of a PTA can also be determined by a preoperative US, our findings may be helpful during the preoperative evaluation of a patient with a preliminary diagnosis of PHPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/rjim-2023-0018","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T10:35:21Z","timestamp":1690367721000},"page":"195-201","source":"Crossref","is-referenced-by-count":1,"title":["A Significant Association between Parathyroid Adenoma Volume and Bone Mineral Loss at Distal Forearm"],"prefix":"10.2478","volume":"61","author":[{"given":"Emre","family":"Gezer","sequence":"first","affiliation":[{"name":"Darica Farabi Training and Research Hospital, Division of Endocrinology and Metabolism , Kocaeli , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"Zekey","sequence":"additional","affiliation":[{"name":"Kocaeli University, Faculty of Medicine , Department of Internal Medicine , Kocaeli , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fc\u015fra Yaprak","family":"Bayrak","sequence":"additional","affiliation":[{"name":"Kocaeli University, Faculty of Medicine , Department of Pathology , Kocaeli , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Cant\u00fcrk","sequence":"additional","affiliation":[{"name":"Kocaeli University, Faculty of Medicine , Department of Endocrinology and Metabolism , Kocaeli , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrin","family":"\u00c7etinarslan","sequence":"additional","affiliation":[{"name":"Kocaeli University, Faculty of Medicine , Department of Endocrinology and Metabolism , Kocaeli , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev","family":"Selek","sequence":"additional","affiliation":[{"name":"Kocaeli University, Faculty of Medicine , Department of Endocrinology and Metabolism , Kocaeli , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"S\u00f6zen","sequence":"additional","affiliation":[{"name":"Kocaeli University, Faculty of Medicine , Department of Endocrinology and Metabolism , Kocaeli , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damla","family":"K\u00f6ksalan","sequence":"additional","affiliation":[{"name":"Kocaeli University, Faculty of Medicine , Department of Endocrinology and Metabolism , Kocaeli , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"2026042914162182761_j_rjim-2023-0018_ref_001","doi-asserted-by":"crossref","unstructured":"YADAV SK, JOHRI G, MISHRA SK, et al. Primary hyperparathyroidism in developing world: A systematic review on the changing clinical profile of the disease. Arch Endocrinol Metab. 2020;64:105\u2013110.","DOI":"10.20945\/2359-3997000000211"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_002","doi-asserted-by":"crossref","unstructured":"SALEEM TFM, HORWITH M, STACK BC. Significance of primary hyperparathyroidism in the management of osteoporosis. Otolaryngol Clin North Am. 2004;37:751\u2013761.","DOI":"10.1016\/j.otc.2004.02.007"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_003","doi-asserted-by":"crossref","unstructured":"SEIBEL MJ, GARTENBERG F, SILVERBERG SJ, et al. Urinary hydroxypyridinium cross-links of collagen in primary hyperparathyroidism. J Clin Endocrinol Metab. 1992;74:481\u2013486.","DOI":"10.1210\/jcem.74.3.1740480"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_004","doi-asserted-by":"crossref","unstructured":"BROUL\u00cdK PD, \u0160T\u011aP\u00c1N JJ, HRADEC E, et al. Correlation between Mass of Parathyroid Adenoma and Biochemical Indicators of Bone Turnover in Patients with Primary Hyperparathyroidism. Exp Clin Endocrinol Diabetes. 1986;88:360\u2013364.","DOI":"10.1055\/s-0029-1210618"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_005","doi-asserted-by":"crossref","unstructured":"SILVERBERG SJ, GARTENBERG F, JACOBS TP, et al. Longitudinal measurements of bone density and biochemical indices in untreated primary hyperparathyroidism. J Clin Endocrinol Metab. 1995;80:723\u2013728.","DOI":"10.1210\/jc.80.3.723"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_006","doi-asserted-by":"crossref","unstructured":"CASTELLANO E, ATTANASIO R, GIANOTTI L, et al. Forearm DXA increases the rate of patients with asymptomatic primary hyperparathyroidism meeting surgical criteria. J Clin Endocrinol Metab. 2016;101:2729\u20132732.","DOI":"10.1210\/jc.2016-1513"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_007","doi-asserted-by":"crossref","unstructured":"SUZUKI S, FUKUSHIMA T, AMI H, et al. Pre- and postoperative bone metabolism of primary hyperparathyroidism. Biomed Pharmacother. 2000;54:90s-96s.","DOI":"10.1016\/S0753-3322(00)80021-9"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_008","doi-asserted-by":"crossref","unstructured":"WOOD K, DHITAL S, CHEN H, et al. What Is the Utility of Distal Forearm DXA in Primary Hyperparathyroidism? Oncologist. 2012;17:322\u2013325.","DOI":"10.1634\/theoncologist.2011-0285"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_009","doi-asserted-by":"crossref","unstructured":"STEINL GK, YEH R, WALKER MD, et al. Preoperative imaging predicts change in bone mineral density after parathyroidectomy for primary hyperparathyroidism. Bone. 2021;145.","DOI":"10.1016\/j.bone.2021.115871"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_010","doi-asserted-by":"crossref","unstructured":"ARRABAL-POLO M\u00c1, SIERRA GIR\u00d3N-PRIETO M, ORGAZ-MOLINA J, et al. Calcium renal lithiasis and bone mineral density. Importance of bone metabolism in urinary lithiasis. Actas Urol Esp. 2013;37:362\u2013367.","DOI":"10.1016\/j.acuroe.2012.10.002"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_011","doi-asserted-by":"crossref","unstructured":"REID LJ, MUTHUKRISHNAN B, PATEL D, et al. Predictors of Nephrolithiasis, Osteoporosis, and Mortality in Primary Hyperparathyroidism. J Clin Endocrinol Metab. 2019;104:3692\u20133700.","DOI":"10.1210\/jc.2018-02483"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_012","doi-asserted-by":"crossref","unstructured":"MOOSGAARD B, VESTERGAARD P, HEICKENDORFF L, et al. Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism. Clin Endocrinol (Oxf). 2005;63:506\u2013513.","DOI":"10.1111\/j.1365-2265.2005.02371.x"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_013","doi-asserted-by":"crossref","unstructured":"LUMB GA, STANBURY SW. Parathyroid function in human vitamin D deficiency and vitamin D deficiency in primary hyperparathyroidism. Am J Med. 1974;56:833\u2013 839.","DOI":"10.1016\/0002-9343(74)90812-2"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_014","doi-asserted-by":"crossref","unstructured":"RAO DS, HONASOGE M, DIVINE GW, et al. Effect of Vitamin D Nutrition on Parathyroid Adenoma Weight: Pathogenetic and Clinical Implications*. J Clin Endocrinol Metab. 2000;85:1054\u20131058.","DOI":"10.1210\/jcem.85.3.6440"},{"key":"2026042914162182761_j_rjim-2023-0018_ref_015","doi-asserted-by":"crossref","unstructured":"BRASIER AR, NUSSBAUM SR. Hungry bone syndrome: Clinical and biochemical predictors of its occurrence after parathyroid surgery. Am J Med. 1988;84:654\u2013660.","DOI":"10.1016\/0002-9343(88)90100-3"}],"container-title":["Romanian Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/rjim-2023-0018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:22:14Z","timestamp":1777486934000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/rjim-2023-0018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,26]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,7,26]]},"published-print":{"date-parts":[[2023,12,1]]}},"alternative-id":["10.2478\/rjim-2023-0018"],"URL":"https:\/\/doi.org\/10.2478\/rjim-2023-0018","relation":{},"ISSN":["2501-062X"],"issn-type":[{"value":"2501-062X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,26]]}}}