{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:56:15Z","timestamp":1792252575924,"version":"4.4.0"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clopidogrel is a widely prescribed prodrug with antithrombotic activity that functions by irreversibly inhibiting the P2Y12 receptors on platelets; nevertheless, drug-induced eosinophilia from this drug is rarely reported. An 81-year-old man was diagnosed with cerebral infarction 2 months earlier and was admitted to our hospital with rash, fever, wheezing, and stomach discomfort after being initiated with clopidogrel treatment. Based on his medical history, chest CT, and gastroscopy, we diagnosed him with clopidogrel-induced hypereosinophilic syndrome. After discontinuation of clopidogrel, the eosinophilia and symptoms improved. In cases of drug-induced eosinophilia, it is important to obtain a detailed medical history.<\/jats:p>","DOI":"10.2478\/rjim-2023-0022","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:59:56Z","timestamp":1693951196000},"page":"216-221","source":"Crossref","is-referenced-by-count":3,"title":["Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis exacerbated by clopidogrel bisulphate"],"prefix":"10.2478","volume":"61","author":[{"given":"Taro","family":"Horino","sequence":"first","affiliation":[{"name":"Department of Endocrinology , Metabolism and Nephrology Kochi Medical School , Kochi University , Kohasu, Oko-cho, Nankoku, Kochi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Department of Haematology and Respiratory Medicine Kochi Medical School , Kochi University , Kohasu, Oko-cho, Nankoku, Kochi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kochi Medical School , Kochi University , Kohasu, Oko-cho, Nankoku, Kochi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Metabolism and Nephrology Kochi Medical School , Kochi University , Kohasu, Oko-cho, Nankoku, Kochi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"2026042914162207028_j_rjim-2023-0022_ref_001","doi-asserted-by":"crossref","unstructured":"SHOMALI W., GOTLIB J. World Health Organization-defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management. Am J Hematol. 2019;94(10):1149-67.","DOI":"10.1002\/ajh.25617"},{"key":"2026042914162207028_j_rjim-2023-0022_ref_002","doi-asserted-by":"crossref","unstructured":"VALENT P., KLION AD., HORNY HP., ROUFOSSE F., GOTLIB J., WELLER PF., et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol. 2012;130(3):607-12.e9.","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"2026042914162207028_j_rjim-2023-0022_ref_003","doi-asserted-by":"crossref","unstructured":"SUNKARA T., RAWLA P., YARLAGADDA KS., GADUPUTI V. Eosinophilic gastroenteritis: diagnosis and clinical perspectives. Clin Exp Gastroenterol. 2019;12:239-53.","DOI":"10.2147\/CEG.S173130"},{"key":"2026042914162207028_j_rjim-2023-0022_ref_004","doi-asserted-by":"crossref","unstructured":"CHUSID MJ., DALE DC., WEST BC., WOLFF SM. 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