{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:35:25Z","timestamp":1777775725140,"version":"3.51.4"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The frequency of thyrotoxicosis may vary between countries and some laboratory test results may be used in etiology research. This study aimed to evaluate the prevalence of thyrotoxicosis diagnoses and laboratory test results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>3246 patients with overt thyrotoxicosis were included in this study. Laboratory test results, epicrisis, thyroid ultrasonography, thyroid scintigraphy, and radioactive iodine uptake test reports of the patients were examined in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thyrotoxicosis was found due to levothyroxine overdose in 58.1% of the patients. When this group was excluded, 36.1% of the patients were diagnosed with toxic multinodular goiter most frequently. TRab levels were 8.5 times higher in Graves\u2019 disease than in other diagnostic groups. Anti-TPO levels were found to be the highest in the Graves\u2019 disease and Hashitoxicosis groups compared to other diagnostic groups (p&lt;0.001). Anti-Tg levels were found to be highest in Graves\u2019 disease, Postpartum thyroiditis, and Hashitoxicosis patients (p&lt;0.001). The free triiodothyronine \/ free thyroxine ratio was significantly higher, a cut-off value of &gt;2.94 provided a sensitivity of 66% and specificity of 64% in diagnosing Graves\u2019 disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The causes of thyrotoxicosis show some differences between countries. Patients using levothyroxine should be informed about drug use and dose titration. The free triiodothyronine \/ free thyroxine ratio can be used in addition to other tests during diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/rjim-2024-0007","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T10:52:01Z","timestamp":1710240721000},"page":"272-278","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the prevalence and laboratory test results of overt thyrotoxicosis cases"],"prefix":"10.2478","volume":"62","author":[{"given":"Rabia","family":"Ezber","sequence":"first","affiliation":[{"name":"Ankara Atat\u00fcrk Sanatoryum Training and Research Hospital , Department of Occupational Disease , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru Demir","family":"\u00dclgen","sequence":"additional","affiliation":[{"name":"Ankara Dr Nafiz K\u00f6rez Sincan Public Hospital, Clinic of Internal Medicine , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130hsan","family":"Ate\u015f","sequence":"additional","affiliation":[{"name":"Ministry of Health Ankara City Hospital, Clinic of Internal Medicine , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisbet","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Ministry of Health Ankara City Hospital, Clinic of Internal Medicine , Ankara , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"2026042913134405662_j_rjim-2024-0007_ref_001","unstructured":"T\u00dcRKIYE ENDOKRINOLOJI VE METABOLIZMA DERNE\u011eI. Hipertiroidi ve Tirotoksikoz. Tiroid Hastal\u0131klar\u0131 Tan\u0131 ve Tedavi Klavuzu. 2023: 95-109."},{"key":"2026042913134405662_j_rjim-2024-0007_ref_002","doi-asserted-by":"crossref","unstructured":"SHARMA A, STAN MN. Thyrotoxicosis: Diagnosis and Management. Mayo Clin Proc. 2019; 94(6): 1048-1064.","DOI":"10.1016\/j.mayocp.2018.10.011"},{"key":"2026042913134405662_j_rjim-2024-0007_ref_003","doi-asserted-by":"crossref","unstructured":"VAN SOESTBERGEN M, VAN DER VIJVER J, GRAAFLAND A. Recurrence of hyperthyroidism in multinodular goiter after long-term drug therapy: a comparison with Graves\u2019 disease. Journal of endocrinological investigation. 2012; 15(11): 797-800.","DOI":"10.1007\/BF03348807"},{"key":"2026042913134405662_j_rjim-2024-0007_ref_004","doi-asserted-by":"crossref","unstructured":"DE LEO S, LEE SY, BRAVERMAN LE. Hyperthyroidism. Lancet (London, England). 2016; 388(10047): 906-18.","DOI":"10.1016\/S0140-6736(16)00278-6"},{"key":"2026042913134405662_j_rjim-2024-0007_ref_005","doi-asserted-by":"crossref","unstructured":"ALFADDA AA, SALLAM RM, ELAWAD GE, ALDHUKAIR H, ALYAHYA MM. Subacute thyroiditis: clinical presentation and long term outcome. Int J Endocrinol. 2014;2014:794943.","DOI":"10.1155\/2014\/794943"},{"key":"2026042913134405662_j_rjim-2024-0007_ref_006","doi-asserted-by":"crossref","unstructured":"ROSS DS, BURCH HB, COOPER DS, GREENLEE MC, LAURBERG P, MAIA AL, et al. American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016; 26(10):1343-1421","DOI":"10.1089\/thy.2016.0229"},{"key":"2026042913134405662_j_rjim-2024-0007_ref_007","doi-asserted-by":"crossref","unstructured":"AZEEZ TA, LAMIDI AO, OSIN IO. A systematic review and meta-analysis of the etiology and treatment patterns of thyrotoxicosis in Africa. 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Ege T\u0131p Dergisi. 2019; 58(3): 282-288.","DOI":"10.19161\/etd.610779"},{"key":"2026042913134405662_j_rjim-2024-0007_ref_018","doi-asserted-by":"crossref","unstructured":"TURA BAHADIR \u00c7, YILMAZ M, KILI\u00c7KAN E. Free triiodothyronine to free thyroxine ratio in the differential diagnosis of thyrotoxicosis and hyperthyroidism: A retrospective study. Int J Clin Pract. 2021; 75:e14003","DOI":"10.1111\/ijcp.14003"}],"container-title":["Romanian Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/rjim-2024-0007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:13:28Z","timestamp":1777486408000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/rjim-2024-0007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,12]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,12]]},"published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.2478\/rjim-2024-0007"],"URL":"https:\/\/doi.org\/10.2478\/rjim-2024-0007","relation":{},"ISSN":["2501-062X"],"issn-type":[{"value":"2501-062X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,12]]}}}