{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:52:28Z","timestamp":1781610748906,"version":"3.54.5"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pancreatic Stone Protein (PSP) is an emerging biomarker for early detection and outcome prediction in infection and sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between PSP plasma measurements on Emergency Department (ED) admission and subsequent hospital length of stay (LOS) among adults with community-acquired infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective observational study, 101 patients presenting to the ED with community-acquired respiratory, urinary or intra-abdominal infections had PSP measured within one hour of presentation. The primary outcome was hospital LOS (days). Association between PSP and LOS was assessed using Spearman's rank correlation. A linear regression analysis was performed demonstrating that only PSP levels were significantly associated with prolonged hospitalization, while LOS was compared between PSP groups (&lt; 50 ng\/ml vs \u2265 50 ng\/ml).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PSP plasma levels were positively correlated with LOS (Spearman's \u03c1 = 0.369, p &lt; 0.001). Median LOS was 4 days in the PSP &lt; 50 ng\/ml group and 9 days in the PSP \u2265 50 ng\/ml group (p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated plasma PSP levels on ED admission were associated with increased hospital stay in patients with community-acquired infections. A PSP threshold of \u2265 50 ng\/ml identified patients at higher risk for prolonged hospitalization. These results suggest that PSP could be a useful biomarker for early risk stratification and resource planning, although threshold validation and multivariable adjustment for confounding are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/rjim-2025-0021","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T22:31:36Z","timestamp":1763159496000},"page":"310-315","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic stone protein predicts hospital stay in community-acquired infections"],"prefix":"10.2478","volume":"63","author":[{"given":"Christos","family":"Michailides","sequence":"first","affiliation":[{"name":"Department of Internal Medicine , University Hospital of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lagadinou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , University Hospital of Patras , Patras , Greece"},{"name":"University of Patras , Medical School of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Georgopoulou","sequence":"additional","affiliation":[{"name":"University of Patras , Medical School of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Kechagia","sequence":"additional","affiliation":[{"name":"University of Patras , Medical School of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni-Konstantina","family":"Velissari","sequence":"additional","affiliation":[{"name":"University of Patras , Medical School of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Polychronopoulos","sequence":"additional","affiliation":[{"name":"University of Patras , Medical School of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Tasouli","sequence":"additional","affiliation":[{"name":"University of Patras , Medical School of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christodoulos","family":"Chatzigrigoriadis","sequence":"additional","affiliation":[{"name":"University of Patras , Medical School of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Velissaris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , University Hospital of Patras , Patras , Greece"},{"name":"University of Patras , Medical School of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markos","family":"Marangos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , University Hospital of Patras , Patras , Greece"},{"name":"University of Patras , Medical School of Patras , Patras , Greece"},{"name":"Division of Infectious Diseases , University Hospital of Patras , Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"2026061610583651255_j_rjim-2025-0021_ref_001","doi-asserted-by":"crossref","unstructured":"LAGU T, ROTHBERG MB, SHIEH MS, PEKOW PS, STEINGRUB JS, LINDENAUER PK. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med. 40(3):754\u2013761; 2012.","DOI":"10.1097\/CCM.0b013e318232db65"},{"key":"2026061610583651255_j_rjim-2025-0021_ref_002","doi-asserted-by":"crossref","unstructured":"REDING T, PALMIERE C, PAZHEPURACKEL C, SCHIESSER M, BIMMLER D, SCHLEGEL A, S\u00dcSS U, STEINER S, MANCINA L, SELEZNIK G, GRAF R. The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP\/regI and PAP\/regIII. Oncotarget. 8(18):30162\u201330174; 2017.","DOI":"10.18632\/oncotarget.16282"},{"key":"2026061610583651255_j_rjim-2025-0021_ref_003","doi-asserted-by":"crossref","unstructured":"KEEL M, H\u00c4RTER L, REDING T, SUN LK, HERSBERGER M, SEIFERT B, BIMMLER D, GRAF R. Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes. Crit Care Med. 37(5):1642\u20131648; 2009.","DOI":"10.1097\/CCM.0b013e31819da7d6"},{"key":"2026061610583651255_j_rjim-2025-0021_ref_004","doi-asserted-by":"crossref","unstructured":"GARC\u00cdA DE GUADIANA-ROMUALDO L, BERGER M, JIM\u00c9NEZSANTOS E, REBOLLO-ACEBES S, JIM\u00c9NEZ-S\u00c1NCHEZ R, ESTEBAN-TORRELLA P, et al. Pancreatic stone protein and soluble CD25 for infection and sepsis in an emergency department. Eur J Clin Invest. 47(4):297\u2013304; 2017.","DOI":"10.1111\/eci.12732"},{"key":"2026061610583651255_j_rjim-2025-0021_ref_005","doi-asserted-by":"crossref","unstructured":"MICHAILIDES C, LAGADINOU M, PARASKEVAS T, PAPANTONIOU K, KAVVOUSANOS M, VASILEIOU A, THOMOPOULOS K, VELISSARIS D, MARANGOS M. The role of the pancreatic stone protein in predicting intra-abdominal infection-related complications: a prospective observational single-center cohort study. Microorganisms. 11(10):2579; 2023.","DOI":"10.3390\/microorganisms11102579"},{"key":"2026061610583651255_j_rjim-2025-0021_ref_006","unstructured":"LAGADINOU M, PARASKEVAS T, VELISSARIS D, MICHAILIDES C, ELEFTHERAKIS G, SAMPSONAS F, SIAKALLIS G, ASSIMAKOPOULOS SF, MARANGOS M. The role of pancreatic stone protein as a prognostic factor for COVID-19 patients. Eur Rev Med Pharmacol Sci. 26(17):6391\u20136395; 2022."},{"key":"2026061610583651255_j_rjim-2025-0021_ref_007","unstructured":"KEEL M, SCHREGENBERGER N, STECKHOLZER U, KENNEY J, et al., Pancreatic stone protein is a novel acute-phase reactant and a marker of pancreatic injury and stress. Crit Care Med. 1999;27(3):675\u2013681."},{"key":"2026061610583651255_j_rjim-2025-0021_ref_008","doi-asserted-by":"crossref","unstructured":"FIDALGO PN, COELHO D, POVOA P. Pancreatic stone protein: review of a new biomarker in sepsis. 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Measurement of pancreatic stone protein in the identification and management of sepsis. Biomark Med. 13(2):135\u2013145; 2019.","DOI":"10.2217\/bmm-2018-0194"},{"key":"2026061610583651255_j_rjim-2025-0021_ref_012","doi-asserted-by":"crossref","unstructured":"SAWSAN ME, SUZAN OM, HEND MM, JOSEPH SZ, NAGWA IO. Serum pancreatic stone protein as a new protein biomarker for late-onset neonatal sepsis. Ann Neonatol J. 2:78\u201392; 2020.","DOI":"10.21608\/anj.2020.31903.1012"},{"key":"2026061610583651255_j_rjim-2025-0021_ref_013","doi-asserted-by":"crossref","unstructured":"PRAZAK J, IRINCHEEVA I, LLEWELYN MJ. Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis. Crit Care. 25:182; 2021.","DOI":"10.1186\/s13054-021-03609-2"}],"container-title":["Romanian Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/rjim-2025-0021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:06:40Z","timestamp":1781608000000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/rjim-2025-0021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,11,14]]},"published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.2478\/rjim-2025-0021"],"URL":"https:\/\/doi.org\/10.2478\/rjim-2025-0021","relation":{},"ISSN":["2501-062X"],"issn-type":[{"value":"2501-062X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}