{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:02:42Z","timestamp":1791288162276,"version":"4.3.0"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein-Barr virus (EBV) is a ubiquitous virus with infections commonly resulting in a latency carrier state. Although the exact role of EBV in cancer pathogenesis remains not entirely clear, it is highly probable that it causes several lymphoid and epithelial malignancies, such as Hodgkin\u2019s lymphoma, NK-T cell lymphoma, Burkitt\u2019s lymphoma, and nasopharyngeal carcinoma. EBV-associated malignancies are associated with a latent form of infection, and several of these EBV-encoded latent proteins are known to mediate cellular transformation. These include six nuclear antigens and three latent membrane proteins. Studies have shown that EBV displays distinct patterns of viral latent gene expression in these lymphoid and epithelial tumors. The constant expression of latent membrane protein 2A (LMP2A) at the RNA level in both primary and metastatic tumors suggests that this protein might be a driving factor in the tumorigenesis of EBV-associated malignancies. LMP2A may cooperate with the aberrant host genome, and thereby contribute to malignant transformation by intervening in signaling pathways at multiple points, especially in the cell cycle and apoptotic pathway. This review summarizes the role of EBV-encoded LMP2A in EBV-associated viral latency and cancers. We will focus our discussions on the molecular interactions of each of the conserved motifs in LMP2A, and their involvement in various signaling pathways, namely the B-cell receptor blockade mechanism, the ubiquitin-mediated (Notch and Wnt) pathways, and the MAPK, PI3-K\/Akt, NK-\u03baB and STAT pathways, which can provide us with important insights into the roles of LMP2A in the EBV-associated latency state and various malignancies.<\/jats:p>","DOI":"10.2478\/s11658-008-0045-2","type":"journal-article","created":{"date-parts":[[2008,12,13]],"date-time":"2008-12-13T12:56:29Z","timestamp":1229172989000},"source":"Crossref","is-referenced-by-count":57,"title":["The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) in latency and cancer"],"prefix":"10.2478","volume":"14","author":[{"given":"Mei-Fong","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah-Wai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suat-Cheng","family":"Peh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref91","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/2281053a0","article-title":"virus in Burkitt s lymphoma and nasopharyngeal carcinoma Antibodies to EBV associated membrane and viral capsid antigens in Burkitt lymphoma patients http dx doi org","volume":"10","author":"Gunven","year":"1970","journal-title":"Nature"},{"key":"ref151","first-page":"143","article-title":"Association of virus with gastric carcinoma with lymphoid stroma","volume":"16","author":"Oda","year":"1993","journal-title":"Am J Pathol"},{"key":"ref141","first-page":"1","article-title":"virus and carcinomas Expression of the viral genome in an undifferentiated gastric carcinoma","volume":"15","author":"Niedobitek","year":"1992","journal-title":"Diagn Mol Pathol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/BF01959075","article-title":"virus infection and associated diseases in children , epidemiology and clinical aspects http dx doi org","volume":"4","author":"Schuster","year":"1992","journal-title":"Eur J Pediatr"},{"key":"ref61","first-page":"320","article-title":"Detection of viral genomes in Reed - 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