{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:36:37Z","timestamp":1740144997796,"version":"3.37.3"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schistosomiasis is a disease with a strong genetic component influenced by socioeconomic and ecological factors. Epidemiological studies have identified several genetic regions involved in the schistosomiasis susceptibility. However, it is not well known what physiological traits are predisposing to the disease. The study of experimental infections in inbred mouse strains with variable genetic susceptibility to the disease offers a good opportunity to tackle this question. F1B6CBA hybrid between the most divergent strains was infected in order to characterize the immunophenotypes that correlate with the susceptibility of schistosomiasis disease in mice. Complete blood counts and immunophenotype were determined at 0, 3, 6, and 9 weeks post infection. Nine weeks after cercariae exposure, animals were perfused and worm recovery was assessed. A large number of hepatic lesions, a reduction in the eosinophil and basophil count in the acute phase of infection and the decreased number of monocytes, neutrophils and B-lymphocytes are phenotypes associated with increased susceptibility to S. mansoni infection.<\/jats:p>","DOI":"10.2478\/s11686-014-0277-4","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T03:23:03Z","timestamp":1407986583000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice"],"prefix":"10.2478","volume":"59","author":[{"given":"Luis","family":"Villar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Blanco-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Castellanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"P\u00e9rez-Losada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Muro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref11","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.actatropica.2007.11.008.http:\/\/dx.doi.org\/10.1016\/j.actatropica.2007.11.008","article-title":"Genetic epidemiology of human schistosomiasis in Brazil","volume":"2","author":"Bethony","year":"2008","journal-title":"Acta Tropica"},{"key":"ref261","doi-asserted-by":"publisher","first-page":"174","DOI":"10.4049\/jimmunol.174.1.435","article-title":"Enhanced egg - induced immunopathology correlates with high IFN - gamma in murine schistosomiasis : identification of two epistatic genetic intervals The of pii http dx doi org","volume":"27","author":"Rutitzky","year":"2005","journal-title":"Journal Immunology"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.pt.2005.06.006.http:\/\/dx.doi.org\/10.1016\/j.pt.2005.06.006","article-title":"Human schistosomiasis and anemia : the relationship and potential mechanisms in","volume":"14","author":"Friedman","year":"2005","journal-title":"Trends Parasitology"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1126\/science.7809629","article-title":"A phagosome - tocytosol pathway for exogenous antigens presented on MHC class I molecules http dx doi org","volume":"19","author":"Kovacsovics","year":"1995","journal-title":"Science"},{"key":"ref91","first-page":"37","article-title":"Variation of hepatic fibrosis and granuloma size among mouse strains infected with Schistosoma mansoni","volume":"10","author":"Cheever","year":"1987","journal-title":"American Journal of Tropical Medicine Hygiene"},{"key":"ref251","first-page":"162","article-title":"Activated eosinophils are the major source of Th - associated cytokines in the schistosome granuloma The of","volume":"26","author":"Rumbley","year":"1999","journal-title":"Journal Immunology"},{"key":"ref291","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ years of image analysis http dx doi org","volume":"30","author":"Schneider","year":"2012","journal-title":"Nature methods"},{"key":"ref191","first-page":"153","article-title":"Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and Ig isotype responses in BALB \/ c mice The of","volume":"20","author":"Lawrence","year":"1994","journal-title":"Journal Immunology"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.smim.2006.07.011.http:\/\/dx.doi.org\/10.1016\/j.smim.2006.07.011","article-title":"Mendelian and complex genetics of susceptibility and resistance to parasitic infections in","volume":"6","author":"Campino","year":"2006","journal-title":"Seminars immunology"},{"key":"ref301","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.exppara.2011.01.016.http:\/\/dx.doi.org\/10.1016\/j.exppara.2011.01.016","article-title":"Evaluation of the role of angiogenic factors in the pathogenesis of schistosomiasis","volume":"31","author":"Shariati","year":"2011","journal-title":"Experimental parasitology"},{"key":"ref331","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.0105-2896.2004.00197.xIMR197[pii].http:\/\/dx.doi.org\/10.1111\/j.0105-2896.2004.00197.x","article-title":"The immunobiology of Th polarization in high - pathology schistosomiasis","volume":"34","author":"Stadecker","year":"2004","journal-title":"Immunology Reviews"},{"key":"ref221","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis http dx doi org","volume":"23","author":"Pearce","year":"2002","journal-title":"Nature Reviews Immunology"},{"key":"ref241","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1056\/NEJMra012396346\/16\/1212.http:\/\/dx.doi.org\/10.1056\/NEJMra012396","article-title":"Schistosomiasis","volume":"25","author":"Ross","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"ref01","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nri2199.http:\/\/dx.doi.org\/10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"1","author":"Anthony","year":"2007","journal-title":"Nature Reviews Immunology"},{"key":"ref281","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/eji.201041327.http:\/\/dx.doi.org\/10.1002\/eji.201041327","article-title":"Exacerbated egg - induced immunopathology in murine Schistosoma mansoni infection is primarily mediated by IL and restrained by IFN - gamma","volume":"29","author":"Rutitzky","year":"2011","journal-title":"European journal of immunology"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1590\/S0074-02762002000700002","article-title":"Experimental models of Schistosoma mansoni infection do http dx doi org","volume":"11","author":"Cheever","year":"2002","journal-title":"Memorias Instituto Oswaldo Cruz"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/35103577","article-title":"Genetics of susceptibility to human infectious disease http dx doi org","volume":"7","author":"Cooke","year":"2001","journal-title":"Nat Reviews Genetic"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1365-3024.2009.01098.x.http:\/\/dx.doi.org\/10.1111\/j.1365-3024.2009.01098.x","article-title":"Immunopathogenesis of human schistosomiasis","volume":"5","author":"Burke","year":"2009","journal-title":"Parasite Immunology"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S1471-4906(03)00101-7","article-title":"The immune response to parasitic helminths : insights from murine models in pii http dx doi org","volume":"15","author":"Gause","year":"2003","journal-title":"Trends Immunology"},{"key":"ref271","first-page":"171","article-title":"Apoptosis by neglect of CD Th cells in granulomas : a novel effector mechanism involved in the control of egg - induced immunopathology in murine schistosomiasis The of http dx doi org","volume":"28","author":"Rutitzky","year":"2003","journal-title":"Journal Immunology"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"174","DOI":"10.4049\/jimmunol.174.2.1063","article-title":"Mast cells , basophils and eosinophils acquire constitutive IL and transcripts during lineage differentiation that are sufficient for rapid cytokine production The of pii http dx doi org","volume":"16","author":"Gessner","year":"2005","journal-title":"IL Journal Immunology"},{"key":"ref201","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.immuni.2005.09.006.http:\/\/dx.doi.org\/10.1016\/j.immuni.2005.09.006","article-title":"A two - step process for cytokine production revealed by IL dual - reporter mice","volume":"21","author":"Mohrs","year":"2005","journal-title":"Immunity"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1084\/jem.182.3.639","article-title":"Antigen presentation to cytotoxic T lymphocytes in vivo http dx doi org","volume":"3","author":"Bevan","year":"1995","journal-title":"Journal Experimental Medicine"},{"key":"ref111","first-page":"294","article-title":"Modulation of blood fluke development in the liver by hepatic CD lymphocytes http dx doi org","volume":"12","author":"Davies","year":"2001","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1046\/j.1365-3024.1997.d01-224.x","article-title":"deficit correlates with chronic , hypersplenomegaly syndrome in male CBA J mice infected with Schistosoma mansoni http dx doi org","volume":"4","author":"Bosshardt","year":"1997","journal-title":"IL Parasite Immunology"},{"key":"ref321","doi-asserted-by":"publisher","first-page":"183","DOI":"10.4049\/jimmunol.0901504.http:\/\/dx.doi.org\/10.4049\/jimmunol.0901504","article-title":"Genetic control of severe egg - induced immunopathology and IL production in murine schistosomiasis The of","volume":"33","author":"Smith","year":"2009","journal-title":"Journal Immunology"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/S0140-6736(06)69440-3.http:\/\/dx.doi.org\/10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"17","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"ref311","doi-asserted-by":"publisher","first-page":"7217","DOI":"10.1016\/j.vaccine.2007.07.021.http:\/\/dx.doi.org\/10.1016\/j.vaccine.2007.07.021","article-title":"The Schistosoma bovis Sb zeta recombinant protein cross - protects against Schistosoma mansoni in BALB \/ c mice","volume":"32","author":"Siles","year":"2007","journal-title":"Vaccine"},{"key":"ref71","first-page":"35","article-title":"The intensity of experimental schistosome infections modulates hepatic pathology","volume":"8","author":"Cheever","year":"1986","journal-title":"American Journal of Tropical Medicine Hygiene"}],"container-title":["Acta Parasitologica"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2478\/s11686-014-0277-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2478\/s11686-014-0277-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2478\/s11686-014-0277-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T05:21:47Z","timestamp":1614835307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.2478\/s11686-014-0277-4\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":29,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2478\/s11686-014-0277-4","relation":{},"ISSN":["1896-1851"],"issn-type":[{"type":"electronic","value":"1896-1851"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}