{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:47:51Z","timestamp":1790390871634,"version":"4.1.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council\u00a0of\u00a0Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/1032(0006)\/2015-EMR-1"],"award-info":[{"award-number":["09\/1032(0006)\/2015-EMR-1"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SB\/YS\/LS-234\/2013"],"award-info":[{"award-number":["SB\/YS\/LS-234\/2013"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR14154\/MED\/29\/965\/2015"],"award-info":[{"award-number":["BT\/PR14154\/MED\/29\/965\/2015"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.2478\/s11686-019-00127-8","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T15:04:07Z","timestamp":1570028647000},"page":"57-67","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison Between Immuno-Clinicopathological Features of Experimental and Human Visceral Leishmaniasis by Leishmania donovani"],"prefix":"10.2478","volume":"65","author":[{"given":"Sheetal","family":"Saini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amogh Anant","family":"Sahasrabuddhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandreshwar Prasad","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerti","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambak Kumar","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"127_CR1","unstructured":"National Vector Borne Disease Control Programme (2018) KALA-AZAR. http:\/\/www.nvbdcp.gov.in\/kala-new.html . Accessed 28 Nov 2018"},{"issue":"5","key":"127_CR2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/j.1365-3024.2006.00817.x","volume":"28","author":"J Carri\u00f3n","year":"2006","unstructured":"Carri\u00f3n J, Nieto A, Iborra S, Iniesta V, Soto M, Folgueira C, Abanades DR, Requena JM, Alonso C (2006) Immunohistological features of visceral leishmaniasis in BALB\/c mice. Parasite Immunol 28(5):173\u2013183","journal-title":"Parasite Immunol"},{"issue":"10","key":"127_CR3","doi-asserted-by":"publisher","first-page":"e47907","DOI":"10.1371\/journal.pone.0047907","volume":"7","author":"N das Dores Moreira","year":"2012","unstructured":"das Dores Moreira N et al (2012) Parasite burden in hamsters infected with two different strains of Leishmania (Leishmania) infantum: \u201cLeishman Donovan Units\u201d versus real-time PCR. PLoS One 7(10):e47907. https:\/\/doi.org\/10.1371\/journal.pone.0047907","journal-title":"PLoS One"},{"issue":"8","key":"127_CR4","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.4049\/jimmunol.158.8.3813","volume":"158","author":"SC Smelt","year":"1997","unstructured":"Smelt SC, Engwerda CR, McCrossen M, Kaye PM (1997) Destruction of follicular dendritic cells during chronic visceral leishmaniasis. J Immunol 158(8):3813\u20133821","journal-title":"J Immunol"},{"issue":"1","key":"127_CR5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4049\/jimmunol.129.1.344","volume":"129","author":"HW Murray","year":"1982","unstructured":"Murray HW, Masur H, Keithly JS (1982) Cell-mediated immune response in experimental visceral leishmaniasis. I. Correlation between resistance to Leishmania donovani and lymphokine-generating capacity. J Immunol 129(1):344\u2013350","journal-title":"J Immunol"},{"issue":"6","key":"127_CR6","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1086\/516482","volume":"175","author":"HW Murray","year":"1997","unstructured":"Murray HW (1997) Endogenous interleukin-12 regulates acquired resistance in experimental visceral leishmaniasis. J Infect Dis 175(6):1477\u20131479","journal-title":"J Infect Dis"},{"issue":"12","key":"127_CR7","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.143.12.4244","volume":"143","author":"KE Squires","year":"1989","unstructured":"Squires KE, Schreiber RD, McElrath MJ, Rubin BY, Anderson SL, Murray HW (1989) Experimental visceral leishmaniasis: role of endogenous IFN-g in host defense and tissue granulomatous response. J Immunol 143(12):4244\u20134249","journal-title":"J Immunol"},{"issue":"2","key":"127_CR8","doi-asserted-by":"publisher","first-page":"e31551","DOI":"10.1371\/journal.pone.0031551","volume":"7","author":"AK Rai","year":"2012","unstructured":"Rai AK, Thakur CP, Singh A, Seth T, Srivastava SK, Singh P, Mitra DK (2012) Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis. PLoS One 7(2):e31551. https:\/\/doi.org\/10.1371\/journal.pone.0031551","journal-title":"PLoS One"},{"issue":"6","key":"127_CR9","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1128\/CVI.00143-12","volume":"19","author":"OP Singh","year":"2012","unstructured":"Singh OP, Gidwani K, Kumar R, Nyl\u00e9n S, Jones SL, Boelaert M, Sacks D, Sundar S (2012) Reassessment of immune correlates in human visceral leishmaniasis as defined by cytokine release in whole blood. Clin Vaccine Immunol 19(6):961\u2013996. https:\/\/doi.org\/10.1128\/CVI.00143-12","journal-title":"Clin Vaccine Immunol"},{"issue":"3","key":"127_CR10","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.4049\/jimmunol.166.3.1912","volume":"166","author":"PC Melby","year":"2001","unstructured":"Melby PC, Chandrasekar B, Zhao W, Coe JE (2001) The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response. J Immunol 166(3):1912\u20131920. https:\/\/doi.org\/10.4049\/jimmunol.166.3.1912","journal-title":"J Immunol"},{"key":"127_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1464-y","author":"ND Moreira","year":"2016","unstructured":"Moreira ND, Vitoriano-Souza J, Roatt BM, Vieira PM, Coura-Vital W, Cardoso JM, Rezende MT, Ker HG, Giunchetti RC, Carneiro CM, Reis AB (2016) Clinical, hematological and biochemical alterations in hamster (Mesocricetus auratus) experimentally infected wit Leishmania infantum through different routes of inoculation. Parasite Vector. https:\/\/doi.org\/10.1186\/s13071-016-1464-y","journal-title":"Parasite Vector"},{"issue":"9","key":"127_CR12","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S1471-4922(02)02347-4","volume":"89","author":"J Moreno","year":"2002","unstructured":"Moreno J, Alvar J (2002) Canine leishmaniasis: epidemiological risk and the experimental model. Trends Parasitol 89(9):399\u2013405. https:\/\/doi.org\/10.1016\/S1471-4922(02)02347-4","journal-title":"Trends Parasitol"},{"issue":"4","key":"127_CR13","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1080\/00034983.1989.11812358","volume":"83","author":"CN Chunge","year":"1989","unstructured":"Chunge CN et al (1989) A rapid staining technique for Leishmania parasites in splenic aspirate smears. Ann Trop Med Parasitol 83(4):361\u2013364","journal-title":"Ann Trop Med Parasitol"},{"key":"127_CR14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.molbiopara.2016.06.005","volume":"207","author":"P Tiwari","year":"2016","unstructured":"Tiwari P, Verma P, Kureel AK, Saini S, Rai AK (2016) Pi inhibits intracellular accumulation of methylglyoxal in promastigote form of L. donovani. Mol Biochem Parasitol 207:89\u201395. https:\/\/doi.org\/10.1016\/j.molbiopara.2016.06.005","journal-title":"Mol Biochem Parasitol"},{"key":"127_CR15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s00436-005-1339-1","volume":"96","author":"A Dube","year":"2005","unstructured":"Dube A, Singh N, Sundar S (2005) Refractoriness to the treatment of sodium stibogluconate in Indian kala-azar field isolates persist in in vitro and in vivo experimental models. Parasitol Res 96:216\u2013223. https:\/\/doi.org\/10.1007\/s00436-005-1339-1","journal-title":"Parasitol Res"},{"issue":"12","key":"127_CR16","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1128\/IAI.57.12.3770-3777.1989","volume":"57","author":"CL Jaffe","year":"1989","unstructured":"Jaffe CL, Rachamim N (1989) Amastigote stage-specific monoclonal antibodies against Leishmania major. Infect Immun 57(12):3770\u20133777","journal-title":"Infect Immun"},{"issue":"1","key":"127_CR17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1515\/ap-2018-0009","volume":"63","author":"KJ Sindhu","year":"2018","unstructured":"Sindhu KJ, Kureel AK, Saini S, Kumari S, Verma P, Rai AK (2018) Characterization of phosphate transporter(s) and understanding their role in Leishmania donovani parasite. Acta Parasitol 63(1):75\u201388. https:\/\/doi.org\/10.1515\/ap-2018-0009","journal-title":"Acta Parasitol"},{"key":"127_CR18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1385\/1-59259-081-0:5","volume-title":"Molecular pathology protocols methods in Molecular Medicine\u2122","author":"H Fan","year":"2001","unstructured":"Fan H, Gulley ML (2001) DNA extraction from fresh or frozen tissues. In: Killeen AA (ed) Molecular pathology protocols methods in Molecular Medicine\u2122, vol 49. Humana Press, Totowa, pp 5\u201310"},{"issue":"4","key":"127_CR19","doi-asserted-by":"publisher","first-page":"e10107","DOI":"10.1371\/journal.pone.0010107","volume":"5","author":"S Verma","year":"2010","unstructured":"Verma S, Kumar R, Katara GK, Singh LC, Negi NS, Ramesh V, Salotra P (2010) Quantification of parasite load in clinical samples of leishmaniasis patients: IL-10 level correlates with parasite load in visceral leishmaniasis. PLoS One 5(4):e10107. https:\/\/doi.org\/10.1371\/journal.pone.0010107","journal-title":"PLoS One"},{"issue":"21","key":"127_CR20","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1001\/jama.1991.03470210076036","volume":"266","author":"F Facchini","year":"1991","unstructured":"Facchini F, Chen YDI, Hollenbeck CB, Reaven GM (1991) Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance and plasma uric acid concentration. J Am Med Assoc 266(21):3008\u20133011","journal-title":"J Am Med Assoc"},{"key":"127_CR21","volume-title":"Clinical methods: the history, physical, and laboratory examinations","author":"DH Vroon","year":"1990","unstructured":"Vroon DH, Israili Z (1990) Alkaline phosphatase and gamma glutamyltransferase. In: Walker HK, Hall WD, Hurst JW (eds) Clinical methods: the history, physical, and laboratory examinations, 3rd edn. Butterworths, Boston","edition":"3"},{"key":"127_CR22","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1093\/infdis\/jis932","volume":"207","author":"H Aslan","year":"2013","unstructured":"Aslan H, Dey R, Meneses C, Castrovinci P, Jeronimo SM, Oliva G, Fischer L, Duncan RC, Nakhasi HL, Valenzuela GJ, Kamhawi S (2013) A new model of progressive visceral leishmaniasis in hamsters by natural transmission via bites of vector sand flies. J Infect Dis 207:1328\u20131338. https:\/\/doi.org\/10.1093\/infdis\/jis932","journal-title":"J Infect Dis"}],"container-title":["Acta Parasitologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2478\/s11686-019-00127-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.2478\/s11686-019-00127-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.2478\/s11686-019-00127-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T05:30:43Z","timestamp":1695274243000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.2478\/s11686-019-00127-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["127"],"URL":"https:\/\/doi.org\/10.2478\/s11686-019-00127-8","relation":{},"ISSN":["1230-2821","1896-1851"],"issn-type":[{"value":"1230-2821","type":"print"},{"value":"1896-1851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,1]]},"assertion":[{"value":"13 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}