{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:48:26Z","timestamp":1788281306520,"version":"build-2803163510"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjph-2021-0028_s_006\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>With the aim of improving personalized treatment of patients on chemotherapy, the objective of the study was to assess the degree of association between selected Quality of life (QoL) indicators and both clinical and imaging cardiac status indicators when detecting deterioration in QoL of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjph-2021-0028_s_007\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cohort clinical study in Hamburg, from August 2017 through October 2020, 59 cancer patients, aged 18-80 years, were evaluated before chemotherapy, and at several follow-ups, using EQ-5D and SF-36 QoL questionnaires, fast strain-encoded (fast-SENC) cardiac magnetic resonance (CMR), conventional CMR, and echocardiography, and further received a clinical and biomarker examination. Data was analyzed using survival analyses. A decline of more than 5% in each observed QoL metric value was defined as the observed event. Patient were separated into groups according to the presentation of cardiotoxicity as per its clinical definition, the establishment of the indication for cardioprotective therapy initiation, and by a worsening in the value of each observed imaging metric by more than 5% in the previous follow-up compared to the corresponding pre-chemotherapy baseline value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjph-2021-0028_s_008\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among clinical cardiac status indicators, the indication for cardioprotective therapy showed statistically good association with QoL scores (EQ-5D p=0.028; SF-36 physical component p=0.016; SF-36 mental component p=0.012). In terms of imaging metrics, the MyoHealth segmental myocardial strain score was the only one demonstrating consistently good QoL score association (EQ-5D p=0.005; SF-36 physical component p=0.056; SF-36 mental component p=0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjph-2021-0028_s_009\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Established fast-SENC CMR scores are capable of highlighting patients with reduced QoL, who require more frequent\/optimal management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/sjph-2021-0028","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T19:00:49Z","timestamp":1634842849000},"page":"199-209","source":"Crossref","is-referenced-by-count":6,"title":["Relationship between quality of life indicators and cardiac status indicators in chemotherapy patients"],"prefix":"10.2478","volume":"60","author":[{"given":"Bla\u017e Matija","family":"Ger\u0161ak","sequence":"first","affiliation":[{"name":"University of Ljubljana, Faculty of Medicine , Vrazov trg 2 , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja","family":"Kukec","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Medicine , Vrazov trg 2 , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Steen","sequence":"additional","affiliation":[{"name":"Center for Preventive Medicine, Marien Hospital , Hamburg , Germany"},{"name":"Faculty of Medicine, University of Hamburg , Hamburg , Germany"},{"name":"Medical Faculty, Heidelberg University , Heidelberg , Germany"},{"name":"Medneo GmbH Hospital & Health Care , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Montenbruck","sequence":"additional","affiliation":[{"name":"Center for Preventive Medicine, Marien Hospital , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"\u0160o\u0161tari\u010d","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Medicine , Vrazov trg 2 , Ljubljana , Slovenia"},{"name":"University Medical Centre Ljubljana, Department of Anaesthesiology and Surgical Intensive Therapy , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne Kristian","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Center for Preventive Medicine, Marien Hospital , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Esch","sequence":"additional","affiliation":[{"name":"Center for Preventive Medicine, Marien Hospital , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kelle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, German Heart Centre Berlin , Berlin , Germany"},{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Hospital Berlin , Berlin , Germany"},{"name":"German Centre for Cardiovascular Research , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Giusca","sequence":"additional","affiliation":[{"name":"GRN Academic Teaching Hospital Weinheim , Weinheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigorios","family":"Korosoglou","sequence":"additional","affiliation":[{"name":"GRN Academic Teaching Hospital Weinheim , Weinheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"W\u00fclfing","sequence":"additional","affiliation":[{"name":"Breast Center, Jerusalem Hospital , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Dent","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, School of Medicine, Duke University , Durham , North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lenihan","sequence":"additional","affiliation":[{"name":"Cardio-Oncology Center of Excellence, School of Medicine, Washington University in St. Louis , St Louis , Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"2026042917431173053_j_sjph-2021-0028_ref_001","doi-asserted-by":"crossref","unstructured":"Strongman H, Gadd S, Matthews A, Mansfield KE, Stanway S, Lyon AR, et al. 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