{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:28:32Z","timestamp":1760549312854},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n\t\t\t\t<jats:p> Mercury is a ubiquitous environmental toxicant that causes a wide range of adverse health effects in humans. Three forms of mercury exist: elemental, inorganic and organic. Each of them has its own profile of toxicity. The aim of the present study was to determine the effect of thimerosal, a topical antiseptic and preservative in vaccines routinely given to children, methyl mercury, and mercuric chloride on cellular viability measured by MTT in Jurkat T cells, a human T leukemia cell line. The treatment of Jurkat T cells with thimerosal caused a significant decrease in cellular viability at 1 \u03bcM (25%, <jats:italic>p&lt;<\/jats:italic>0.05; IC50: 10 \u03bcM). Methyl mercury exhibited a significant decrease in cellular viability at 50 \u03bcM (33%, <jats:italic>p&lt;<\/jats:italic>0.01; IC50: 65 \u03bcM). Mercuric chloride (HgCl<jats:sub>2<\/jats:sub>) did not show any significant change in cellular survival. Our findings showed that contrary to thimerosal and methyl mercury, mercuric chloride did not modify Jurkat T cell viability.<\/jats:p>","DOI":"10.2478\/v10102-012-0026-1","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T15:20:51Z","timestamp":1360768851000},"page":"159-161","source":"Crossref","is-referenced-by-count":14,"title":["Effect of thimerosal, methylmercury, and mercuric chloride in Jurkat T Cell Line"],"prefix":"10.2478","volume":"5","author":[{"given":"Gianpaolo","family":"Guzzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo D.","family":"Pigatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Spadari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina A.M.","family":"La Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","container-title":["Interdisciplinary Toxicology"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/intox\/5\/3\/article-p159.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/view\/j\/intox.2012.5.issue-3\/v10102-012-0026-1\/v10102-012-0026-1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T15:56:13Z","timestamp":1590854173000},"score":1,"resource":{"primary":{"URL":"https:\/\/content.sciendo.com\/doi\/10.2478\/v10102-012-0026-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,1]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2478\/v10102-012-0026-1","relation":{},"ISSN":["1337-9569","1337-6853"],"issn-type":[{"value":"1337-9569","type":"electronic"},{"value":"1337-6853","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8,1]]}}}