{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:41:00Z","timestamp":1777462860823,"version":"3.51.4"},"reference-count":88,"publisher":"Polish Academy of Sciences Chancellery","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies show that a representative of phospholipids, namely lysophosphatidic acid (LPA) and its receptors (LPA<jats:sub>1-3<\/jats:sub>) play a significant role in the reproductive processes, i. a, in the modulation of the uterine contractility. The participation of LPA<jats:sub>3<\/jats:sub>in the reproductive processes has been revealed in mice and has not been studied in gilts. Therefore, in the present study we investigated the role\/action of LPA and its receptors LPA<jats:sub>1<\/jats:sub>, LPA<jats:sub>2<\/jats:sub>and LPA<jats:sub>3<\/jats:sub>on the contraction activity in the porcine uterus. The study was conducted on an experimental model in which the pig uterus consisted of the one whole uterine horn and a part of the second horn, both connected with the uterine corpus. Uterine strips consisting of the endometrium with the myometrium (ENDO\/MYO) and myometrium (MYO) alone were collected on days 12-14 of the estrous cycle (control group; n = 5) or pregnancy (experimental group; n = 5). Two analogues of LPA at increasing doses were used: oleoyl-sn-glycero- 3-phosphate (L-\u03b1-LPA, a selective agonist of LPA<jats:sub>1<\/jats:sub>and LPA<jats:sub>2<\/jats:sub>receptors; 10<jats:sup>-7<\/jats:sup>M; 10<jats:sup>-6<\/jats:sup>M and 10<jats:sup>-5<\/jats:sup>M) and 1-oleoyl-2-<jats:italic>O<\/jats:italic>-methyl-<jats:italic>rac<\/jats:italic>-glycerophosphothionate (OMPT, a selective agonist of LPA3 receptor; 68 nM; 136 nM and 680 nM). L-\u03b1-LPA caused an increase in the contraction tension, amplitude and frequency of ENDO\/MYO from the uterine horn with the developing embryos. This effect was not observed in MYO in both groups examined. In the ENDO\/MYO strips of the uterine horn with developing embryos, OMPT significantly increased the contraction tension at the highest dose (680 nM) and amplitude at all doses examined, while frequency of contractions was decreased at doses of 136 nM and 680 nM. In the MYO strips of the uterine horn with embryos a significant increase in the contraction tension and amplitude after the highest dose of OMPT was observed. The results obtained imply the important role of receptors LPA<jats:sub>1<\/jats:sub>, LPA<jats:sub>2<\/jats:sub>and LPA<jats:sub>3<\/jats:sub>in the contraction activity of the porcine uterus during early pregnancy.<\/jats:p>","DOI":"10.2478\/v10181-012-0100-9","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T14:53:41Z","timestamp":1363013621000},"page":"635-643","source":"Crossref","is-referenced-by-count":21,"title":["Participation of analogues of lysophosphatidic acid (LPA): oleoyl-sn-glycero-3-phosphate (L-\u03b1-LPA) and 1-oleoyl-2-O-methyl-rac-glycerophosphothionate (OMPT) in uterine smooth muscle contractility of the pregnant pigs"],"prefix":"10.24425","volume":"15","author":[{"given":"W.","family":"Markiewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kami\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bogacki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ma\u015blanka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jaroszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37468","reference":[{"key":"ref01","first-page":"273","article-title":"An Characterization of a novel subtype of human protein - coupled receptor for lysophosphatidic acid","author":"Bleu","year":"1998","journal-title":"J Biol Chem"},{"key":"ref701","first-page":"202","article-title":"Lysophosphatidic acid inhibits cholera toxin - induced secretory diarrhea through CFTR - dependent protein interactions","author":"Li","year":"2005","journal-title":"J Exp Med"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0026-895X(25)09327-7","article-title":"Palmitoyl - serine palmitoyl - tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors","author":"Liliom","year":"1996","journal-title":"Mol Pharmacol"},{"key":"ref861","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0092-8674(89)90868-4","article-title":"Lysophosphatidate - induced cell proliferation : identification and dissection of signaling pathways mediated by proteins","volume":"59","author":"Van Corven","year":"1989","journal-title":"Cell"},{"key":"ref271","first-page":"270","article-title":"a oocytes express multiple receptors for LPA - like lipid mediators","author":"Liliom","year":"1996","journal-title":"Am J Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1095\/biolreprod66.4.859","article-title":"LT Lysophosphatidic acid and its role in reproduction","author":"Budnik","year":"2002","journal-title":"Biol Reprod"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molmed.2005.12.001","article-title":"Emerging medicinal roles for lysophospholipid signaling","volume":"12","author":"Gardell","year":"2006","journal-title":"Trends Mol Med"},{"key":"ref181","first-page":"433","article-title":"a receptor and \u03b2 - adrenoceptor share in the inhibition of porcine uterine contractility in a muscle layer - dependent manner","author":"Kitazawa","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0024-3205(99)00243-X","article-title":"Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats","author":"Tokumura","year":"1999","journal-title":"Life Sci"},{"key":"ref531","first-page":"262","article-title":"Local and systemic effects of embryos on uterine tissues during early pregnancy in pigs","author":"Franczak","year":"2009"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0026-895X(25)09327-7","article-title":"Palmitoyl - serine palmitoyl - tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors","author":"Liliom","year":"1996","journal-title":"Mol Pharmacol"},{"key":"ref451","first-page":"273","article-title":"An Characterization of a novel subtype of human protein - coupled receptor for lysophosphatidic acid","author":"Bleu","year":"1998","journal-title":"J Biol Chem"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0898-6568(04)00043-9","article-title":"Lysophospholipase its role in production","volume":"16","author":"Xie","year":"2004","journal-title":"Cell Signal"},{"key":"ref131","first-page":"73","article-title":"Lysophospholipid receptors signaling biology","author":"Ishii","year":"2004","journal-title":"Annu Rev Biochem"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"654","DOI":"10.22358\/jafs\/66822\/2007","article-title":"The influence of inflammatory process on prostaglandin alpha contractile activity in porcine uterus","volume":"16","author":"Kucharski","year":"2007","journal-title":"J Anim Feed Sci"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0092-8674(89)90868-4","article-title":"Lysophosphatidate - induced cell proliferation : identification and dissection of signaling pathways mediated by proteins","volume":"59","author":"Van Corven","year":"1989","journal-title":"Cell"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2754\/avb201079020249","article-title":"Participation of prostaglandin in contractile activity of inflamed porcine uterus","author":"Jana","year":"2010","journal-title":"Acta Vet Brno"},{"key":"ref731","first-page":"339","article-title":"and cholinergic nervature of female reproductive organs in pig in particular periods of ovarian pregnancy and lactation cycles","author":"\u0141akomy","year":"1987"},{"key":"ref851","first-page":"875","article-title":"Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma","author":"Tokumura","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"ref751","first-page":"183","article-title":"its occurrence and relevance in the female reproductive system","author":"Markiewicz","year":"2003","journal-title":"Histochem"},{"key":"ref501","first-page":"1","article-title":"a Requirement for the lpa lysophosphatidic acid receptor gene in normal suckling behavior","author":"Contos","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1124\/mol.58.6.1188","article-title":"Lysophosphatidic acid receptors","author":"Contos","year":"2000","journal-title":"Mol Pharmacol"},{"key":"ref151","first-page":"119","article-title":"Effect of estradiol and progesterone on noradrenaline content in nerves of the oviduct uterus and vagina in ovariectomized pigs","author":"Kaleczyc","year":"1994","journal-title":"Histochem"},{"key":"ref361","first-page":"276","article-title":"Distribution of adrenergic and cholinergic nerves in the porcine myometrium during the oestrous cycle histochemical investigation","author":"Thilander","year":"1989"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0196-9781(00)00169-8","article-title":"Characterization of functional endothelin receptors in the porcine myometrium","volume":"21","author":"Isaka","year":"2000","journal-title":"Peptides"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1073\/pnas.91.5.1908","article-title":"Lysophosphatidic acid possesses dual action in cell proliferation","author":"Tigyi","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref201","first-page":"469","article-title":"Pregnancy - associated changes in responsiveness of the porcine myometrium to bioactive substances","author":"Kitazawa","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"ref631","first-page":"433","article-title":"a receptor and \u03b2 - adrenoceptor share in the inhibition of porcine uterine contractility in a muscle layer - dependent manner","author":"Kitazawa","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"ref221","first-page":"151","article-title":"In vitro contractile activity of porcine myometrium during luteolysis and early pregnancy : effect of oxytocin and progesterone","author":"Kurowicka","year":"2005","journal-title":"Reprod Biol"},{"key":"ref741","first-page":"281","article-title":"The distribution and co - localization of immunoreactivity to nitric oxide synthase vasoactive intestinal polypeptide and substance P within nerve fibres supplying bovine and porcine female genital organs","author":"Majewski","year":"1995","journal-title":"Cell Tissue Res"},{"key":"ref331","first-page":"149","article-title":"Analysis of lysophosphatidic acid receptor - induced endometrial prostaglandin - endoperoxide synthase expression in the porcine uterus","author":"Seo","year":"2008","journal-title":"Endocrinology"},{"key":"ref771","first-page":"278","article-title":"Identification of as a novel protein - coupled receptor for lysophosphatidic acid structurally distant from the Edg family","volume":"23","author":"Noguchi","year":"2003","journal-title":"J Biol Chem"},{"key":"ref551","first-page":"77","article-title":"Embryo spacing and implantation timing are differentially regulated by - mediated lysophosphatidic acid signaling in mice","author":"Hama","year":"2007","journal-title":"Biol Reprod"},{"key":"ref11","first-page":"274","article-title":"Molecular cloning and characterization of a novel human protein - coupled receptor for lysophosphatidic acid","author":"Bandoh","year":"1999","journal-title":"J Biol Chem"},{"key":"ref581","first-page":"73","article-title":"Lysophospholipid receptors signaling biology","author":"Ishii","year":"2004","journal-title":"Annu Rev Biochem"},{"key":"ref721","first-page":"270","article-title":"a oocytes express multiple receptors for LPA - like lipid mediators","author":"Liliom","year":"1996","journal-title":"Am J Physiol"},{"key":"ref461","first-page":"274","article-title":"Molecular cloning and characterization of a novel human protein - coupled receptor for lysophosphatidic acid","author":"Bandoh","year":"1999","journal-title":"J Biol Chem"},{"key":"ref341","first-page":"112","article-title":"levels of estrogen receptors \u03b1 and \u03b2 and progesterone receptors in the cyclic and inseminated \/ early pregnant sow uterus","author":"Sukjumlong","year":"2009","journal-title":"RNA Anim Reprod Sci"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0898-6568(04)00043-9","article-title":"Lysophospholipase its role in production","volume":"16","author":"Xie","year":"2004","journal-title":"Cell Signal"},{"key":"ref651","first-page":"469","article-title":"Pregnancy - associated changes in responsiveness of the porcine myometrium to bioactive substances","author":"Kitazawa","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"ref321","first-page":"278","article-title":"Identification of as a novel protein - coupled receptor for lysophosphatidic acid structurally distant from the Edg family","volume":"23","author":"Noguchi","year":"2003","journal-title":"J Biol Chem"},{"key":"ref441","first-page":"435","article-title":"mediated lysophosphatidic acid signalling in embryo implantation and spacing","author":"Ye","year":"2005","journal-title":"Nature"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molmed.2005.12.001","article-title":"Emerging medicinal roles for lysophospholipid signaling","volume":"12","author":"Gardell","year":"2006","journal-title":"Trends Mol Med"},{"key":"ref291","first-page":"281","article-title":"The distribution and co - localization of immunoreactivity to nitric oxide synthase vasoactive intestinal polypeptide and substance P within nerve fibres supplying bovine and porcine female genital organs","author":"Majewski","year":"1995","journal-title":"Cell Tissue Res"},{"key":"ref401","first-page":"875","article-title":"Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma","author":"Tokumura","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"ref481","first-page":"442","article-title":"In vitro pharmacological characterization of the prostanoid receptor population in the non - pregnant porcine myometrium","author":"Cao","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1095\/biolreprod45.6.831","article-title":"Autonomic innervation of the circular and longitudinal layers in swine myometrium","author":"Taneike","year":"1991","journal-title":"Biol Reprod"},{"key":"ref311","first-page":"270","article-title":"Lysophosphatidic acid a multifunctional phospholipid messenger","author":"Moolenaar","year":"1995","journal-title":"J Biol Chem"},{"key":"ref831","first-page":"267","article-title":"Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC cells","volume":"12","author":"Tigyi","year":"1992","journal-title":"pheochromocytoma J Biol Chem"},{"key":"ref101","first-page":"77","article-title":"Embryo spacing and implantation timing are differentially regulated by - mediated lysophosphatidic acid signaling in mice","author":"Hama","year":"2007","journal-title":"Biol Reprod"},{"key":"ref821","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1073\/pnas.91.5.1908","article-title":"Lysophosphatidic acid possesses dual action in cell proliferation","author":"Tigyi","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref381","first-page":"267","article-title":"Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC cells","volume":"12","author":"Tigyi","year":"1992","journal-title":"pheochromocytoma J Biol Chem"},{"key":"ref41","first-page":"117","article-title":"Effect of oxytocin on concentration of \u03b1 in the uterine lumen and subsequent endometrial responsiveness to oxytocin in pigs","author":"Carnahan","year":"1999","journal-title":"J Reprod Fertil"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1128\/MCB.22.19.6921-6929.2002","article-title":"Characterization of lpa and lpa lpa lysophosphatidic acid receptor knockout mice : signaling deficits without obvious phenotypic abnormality attributable to lpa","volume":"22","author":"Contos","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref31","first-page":"442","article-title":"In vitro pharmacological characterization of the prostanoid receptor population in the non - pregnant porcine myometrium","author":"Cao","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"ref761","first-page":"270","article-title":"Lysophosphatidic acid a multifunctional phospholipid messenger","author":"Moolenaar","year":"1995","journal-title":"J Biol Chem"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2885.1997.tb00094.x","article-title":"Histamine mediates the muscle layer - specific responses in the isolated swine myometrium","volume":"20","author":"Kitazawa","year":"1997","journal-title":"J Vet Pharmacol Ther"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/S0093-691X(02)00657-X","article-title":"EG NM Taverne MA Myometrial activity around estrus in sows : spontaneous activity and effects of estrogens cloptrostenol seminal plasma and clenbuterol","author":"Langendijk","year":"2002","journal-title":"Theriogenology"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/mrd.20862","article-title":"The influence of embryo presence on prostaglandins synthesis and prostaglandin alpha content in corpora lutea during periimplantation period in the pig","author":"Wasielak","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.theriogenology.2004.09.027","article-title":"NM Uterine activity sperm transport and the role of boar stimuli around insemination in sows","author":"Langendijk","year":"2005","journal-title":"Theriogenology"},{"key":"ref791","first-page":"112","article-title":"levels of estrogen receptors \u03b1 and \u03b2 and progesterone receptors in the cyclic and inseminated \/ early pregnant sow uterus","author":"Sukjumlong","year":"2009","journal-title":"RNA Anim Reprod Sci"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.theriogenology.2004.09.027","article-title":"NM Uterine activity sperm transport and the role of boar stimuli around insemination in sows","author":"Langendijk","year":"2005","journal-title":"Theriogenology"},{"key":"ref811","first-page":"276","article-title":"Distribution of adrenergic and cholinergic nerves in the porcine myometrium during the oestrous cycle histochemical investigation","author":"Thilander","year":"1989"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1128\/MCB.22.19.6921-6929.2002","article-title":"Characterization of lpa and lpa lpa lysophosphatidic acid receptor knockout mice : signaling deficits without obvious phenotypic abnormality attributable to lpa","volume":"22","author":"Contos","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1124\/mol.58.6.1188","article-title":"Lysophosphatidic acid receptors","author":"Contos","year":"2000","journal-title":"Mol Pharmacol"},{"key":"ref161","first-page":"85","article-title":"Quantitative expression of lysophosphatidic acid receptor gene in porcine endometrium during the periimplantation period and estrous cycle Other Lipid","author":"Kami\u0144ska","year":"2008","journal-title":"Prostaglandins"},{"key":"ref611","first-page":"85","article-title":"Quantitative expression of lysophosphatidic acid receptor gene in porcine endometrium during the periimplantation period and estrous cycle Other Lipid","author":"Kami\u0144ska","year":"2008","journal-title":"Prostaglandins"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1095\/biolreprod45.6.831","article-title":"Autonomic innervation of the circular and longitudinal layers in swine myometrium","author":"Taneike","year":"1991","journal-title":"Biol Reprod"},{"key":"ref81","first-page":"262","article-title":"Local and systemic effects of embryos on uterine tissues during early pregnancy in pigs","author":"Franczak","year":"2009"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2754\/avb201079020249","article-title":"Participation of prostaglandin in contractile activity of inflamed porcine uterus","author":"Jana","year":"2010","journal-title":"Acta Vet Brno"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0196-9781(01)00402-8","article-title":"Muscle layer - and region - dependent distributions of oxytocin receptors in the porcine myometrium","volume":"22","author":"Kitazawa","year":"2001","journal-title":"Peptides"},{"key":"ref281","first-page":"339","article-title":"and cholinergic nervature of female reproductive organs in pig in particular periods of ovarian pregnancy and lactation cycles","author":"\u0141akomy","year":"1987"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"654","DOI":"10.22358\/jafs\/66822\/2007","article-title":"The influence of inflammatory process on prostaglandin alpha contractile activity in porcine uterus","volume":"16","author":"Kucharski","year":"2007","journal-title":"J Anim Feed Sci"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0024-3205(99)00243-X","article-title":"Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats","author":"Tokumura","year":"1999","journal-title":"Life Sci"},{"key":"ref641","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0196-9781(01)00402-8","article-title":"Muscle layer - and region - dependent distributions of oxytocin receptors in the porcine myometrium","volume":"22","author":"Kitazawa","year":"2001","journal-title":"Peptides"},{"key":"ref781","first-page":"149","article-title":"Analysis of lysophosphatidic acid receptor - induced endometrial prostaglandin - endoperoxide synthase expression in the porcine uterus","author":"Seo","year":"2008","journal-title":"Endocrinology"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0196-9781(00)00169-8","article-title":"Characterization of functional endothelin receptors in the porcine myometrium","volume":"21","author":"Isaka","year":"2000","journal-title":"Peptides"},{"key":"ref251","first-page":"202","article-title":"Lysophosphatidic acid inhibits cholera toxin - induced secretory diarrhea through CFTR - dependent protein interactions","author":"Li","year":"2005","journal-title":"J Exp Med"},{"key":"ref301","first-page":"183","article-title":"its occurrence and relevance in the female reproductive system","author":"Markiewicz","year":"2003","journal-title":"Histochem"},{"key":"ref491","first-page":"117","article-title":"Effect of oxytocin on concentration of \u03b1 in the uterine lumen and subsequent endometrial responsiveness to oxytocin in pigs","author":"Carnahan","year":"1999","journal-title":"J Reprod Fertil"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1095\/biolreprod66.4.859","article-title":"LT Lysophosphatidic acid and its role in reproduction","author":"Budnik","year":"2002","journal-title":"Biol Reprod"},{"key":"ref871","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/mrd.20862","article-title":"The influence of embryo presence on prostaglandins synthesis and prostaglandin alpha content in corpora lutea during periimplantation period in the pig","author":"Wasielak","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"ref51","first-page":"1","article-title":"a Requirement for the lpa lysophosphatidic acid receptor gene in normal suckling behavior","author":"Contos","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2885.1997.tb00094.x","article-title":"Histamine mediates the muscle layer - specific responses in the isolated swine myometrium","volume":"20","author":"Kitazawa","year":"1997","journal-title":"J Vet Pharmacol Ther"},{"key":"ref601","first-page":"119","article-title":"Effect of estradiol and progesterone on noradrenaline content in nerves of the oviduct uterus and vagina in ovariectomized pigs","author":"Kaleczyc","year":"1994","journal-title":"Histochem"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/S0093-691X(02)00657-X","article-title":"EG NM Taverne MA Myometrial activity around estrus in sows : spontaneous activity and effects of estrogens cloptrostenol seminal plasma and clenbuterol","author":"Langendijk","year":"2002","journal-title":"Theriogenology"},{"key":"ref891","first-page":"435","article-title":"mediated lysophosphatidic acid signalling in embryo implantation and spacing","author":"Ye","year":"2005","journal-title":"Nature"},{"key":"ref671","first-page":"151","article-title":"In vitro contractile activity of porcine myometrium during luteolysis and early pregnancy : effect of oxytocin and progesterone","author":"Kurowicka","year":"2005","journal-title":"Reprod Biol"}],"container-title":["Polish Journal of Veterinary Sciences"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/pjvs\/15\/4\/article-p635.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/view\/j\/pjvs.2012.15.issue-4\/v10181-012-0100-9\/v10181-012-0100-9.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T23:56:59Z","timestamp":1745971019000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.pan.pl\/dlibra\/publication\/114033\/edition\/99091\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,1]]},"references-count":88,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2478\/v10181-012-0100-9","relation":{},"ISSN":["1505-1773"],"issn-type":[{"value":"1505-1773","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12,1]]}}}