{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:20:23Z","timestamp":1790857223487,"version":"4.1.0"},"reference-count":47,"publisher":"National Institute of Industrial Health","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ind Health"],"published-print":{"date-parts":[[2010]]},"DOI":"10.2486\/indhealth.ms1129","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T02:30:14Z","timestamp":1277951414000},"page":"783-795","source":"Crossref","is-referenced-by-count":72,"title":["Pulmonary Toxicity of Intratracheally Instilled Multiwall Carbon Nanotubes in Male Fischer 344 Rats"],"prefix":"10.2486","volume":"48","author":[{"given":"Shigetoshi","family":"AISO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"YAMAZAKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"UMEDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"ASAKURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"KASAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutoshi","family":"TAKAYA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"TOYA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"KODA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasuke","family":"NAGANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heihachiro","family":"ARITO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"FUKUSHIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Martin CR, Kohli P (2003) The emerging field of nanotube biotechnology. Nat Rev Drug Discov 2, 29-37.","DOI":"10.1038\/nrd988"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14199"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Ball P (2001) Roll up for the revolution. Nature 414, 142-4.","DOI":"10.1038\/35102721"},{"key":"4","unstructured":"4) Toray Corporate Business Research, INC. Report on the survey of production and use of nanomaterials in Japan, -Fy 2007-. http:\/\/www.mhlw.go.jp\/shingi\/2008\/04\/dl\/s0404-3c.pdf. Accessed July 21, 2009 (in Japanese)."},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2131\/jts.33.105"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2131\/jts.34.65"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2008.111"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg243"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00084.2005"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Mercer RR, Scabilloni J, Wang L, Kisin E, Murray AR, Schwegler-Berry D, Shvedova AA, Castranova V (2008) Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model. Am J Physiol Lung Cell Mol Physiol 294, L87-L97.","DOI":"10.1152\/ajplung.00186.2007"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Arepalli S, Hubbs AF, Mercer RR, Keohavong P, Sussman N, Jin J, Yin J, Stone S, Chen BT, Deye G, Maynard A, Castranova V, Baron PA, Kagan VE (2008) Inhalation vs. aspiration of single walled carbon nanotubes in C57BL\/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am J Pysiol Lung Cell Mol Physiol 295, L552-L65.","DOI":"10.1152\/ajplung.90287.2008"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Muller J, Huaux F, Moreau N, Misson P, Heilier JF, Delos M, Arras M, Fonseca A, Nagy JB, Lison D (2005) Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol 207, 221-31.","DOI":"10.1016\/j.taap.2005.01.008"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-3-1"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.03.018"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Warheit DB, Laurence BR, Reed KL, Roach DH, Reynolds GAM, Webb TR (2004) Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77, 117-25.","DOI":"10.1093\/toxsci\/kfg228"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Elgrabli D, Abella-Gallart S, Robidel F, Rogerieux F, Boczkowski J, Lacroix G (2008) Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes. Toxicol 253, 131-6.","DOI":"10.1016\/j.tox.2008.09.004"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Mitchell LA, Gao J, Wal RV, Gigliotti A, Burchiel SW, McDonald JD (2007) Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci 100, 203-14.","DOI":"10.1093\/toxsci\/kfm196"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Muller J, Huaux F, Fonseca A, Nagy JB, Moreau N, Delos M, Raymundo-Pi&ntilde;ero E, B&eacute;guin F, Kirsch-Volders M, Fenoglio I, Fubini B, Lison D (2008) Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicologucal aspects. Chem Res Toxicol 21, 1698-705.","DOI":"10.1021\/tx800101p"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Muller J, Decordier I, Hoet PH, Lombaert N, Thomassen L, Huaux F, Lison D, Kirsch-Volders M (2008) Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells. Carcinogenesis 29, 427-33.","DOI":"10.1093\/carcin\/bgm243"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Hubbard R, Venn A, Lewis S, Britton J (2000) Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. Am J Respir Crit Care Med 161, 5-8.","DOI":"10.1164\/ajrccm.161.1.9906062"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Fraire AE, Greenberg SD (1973) Carcinoma and diffuse interstitial fibrosis of lung. Cancer 31, 1078-86.","DOI":"10.1002\/1097-0142(197305)31:5<1078::AID-CNCR2820310507>3.0.CO;2-1"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.MS1128"},{"key":"23","unstructured":"23) National Research Council (1996) Guide for the care and use of laboratory animals. National Academy Press, Institute of Laboratory Animal Resources Commission on Life Sciences, NRC, Washington, DC."},{"key":"24","unstructured":"24) Hubbs A, Mercer RR, Coad JE, Barrelli LA, Willard PA, Sriram K, Wolfarth M, Castranova V, Porter D (2009) Persistent pulmonary inflammation, airway mucous metaplasia and migration of multiwalled carbon nanotubes from the lung after subchronic exposure. The Toxicologist (48th Annual Meeting of SOT) 457."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Morrow PE (1972) Lymphatic drainage of the lung in dust clearance. Ann NY Acad Sci 200, 46-65.","DOI":"10.1111\/j.1749-6632.1972.tb40177.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(85)90083-8"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Takahashi S, Patrick G (1987) Patterns of lymphatic drainage to individual thoracic and cervical lymph nodes in the rat. Lab Anim 21, 31-4.","DOI":"10.1258\/002367787780740671"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Lehnert BE, Valdez YE, Stewart CC (1986) Translocation of particles to the tracheobronchial lympth nodes after lung deposition: kinetics and particle-cell relationships. Exp Lung Res 10, 245-66.","DOI":"10.3109\/01902148609061496"},{"issue":"5","key":"29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1165\/ajrcmb\/6.5.535","volume":"6","year":"1992","ISSN":"https:\/\/id.crossref.org\/issn\/1044-1549","issn-type":"print"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8102"},{"issue":"5","key":"31","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/00039896.1986.9936697","volume":"41","year":"1986","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9896","issn-type":"print"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Suzuki Y, Kohyama N (1991) Translocation of inhaled asbestos fibers from the lung to other tissues. Am J Ind Med 19, 701-4.","DOI":"10.1002\/ajim.4700190603"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.2307\/3430661"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Jensen CG, Jensen LCW, Rieder CL, Cole RW, Ault JG (1996) Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis. Carcinogenesis 17, 2013-21.","DOI":"10.1093\/carcin\/17.9.2013"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Gross KB, White HJ, Smiler KL (1984) Functional and morphologic changes in the lungs after a single intratracheal instillation of silica. Am Rev Respir Dis 129, 833-9.","DOI":"10.1164\/arrd.1984.129.5.833"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Porter DW, Hubbs A, Mercer R, Robinson VA, Ramsey D, McLaurin J, Khan A, Battelli L, Brumbaugh K, Teass A, Castranova V (2004) Progression of lung inflammation and damage in rats after cessation of silica inhalation. Toxicol Sci 79, 370-80.","DOI":"10.1093\/toxsci\/kfh110"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(88)90284-9"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Oberd&#246;rster G (1995) Lung particle overload: implications for occupational exposures to particles. Regul Toxicol Pharmacol 27, 123-35.","DOI":"10.1006\/rtph.1995.1017"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Driscoll KE, Costa DL, Hatch G, Henderson R, Oberd&#246;rster G, Salem H, Schlesinger B (2000) Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci 55, 123-35.","DOI":"10.1093\/toxsci\/55.1.24"},{"key":"40","unstructured":"40) Drew RT, Kuschner M, Bernstein DM (1987) The chronic effects of exposure of rats to sized glass fibers. Ann Occup Hyg 31, 711-29."},{"key":"41","unstructured":"41) Mauderly JL, Tesarek JE, Sifford LJ, Sifford LJ (1979) Respiratory measurements of unsedated small laboratory mammals using nonrebreathing valves. Lab Anim Sci 29, 323-9."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Leong BK, Sabaitis CP, Rop DA and Aaron CS (1998) Quantitative morphometric analysis of pulmonary deposition of aerosol particles inhaled via intratracheal nebulization, intratracheal instillation or nose-only inhalation in rats. J Appl Toxicol 18, 149-60.","DOI":"10.1002\/(SICI)1099-1263(199803\/04)18:2<149::AID-JAT490>3.0.CO;2-L"},{"key":"43","unstructured":"43) Occupational Safety and Health Administration (2006) Regulation (Standards-29 CFR). Part 1910, occupational safety and health standards. Toxic and hazardous substances. Table Z-1 Limits for air contaminants. OSHA, Washington, DC. http:\/\/www.osha.gov\/pls\/oshaweb\/owadisp.show_document?p_table=STANDARDS&#38;p_id=9992#. Accessed July 21, 2009."},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V (2004) Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health, Part A 67, 87-107.","DOI":"10.1080\/15287390490253688"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Galer DM, Leung HW, Sussman RG, Trzos RJ (1992) Scientific and practical considerations for the development of occupational exposure limits (OELs) for chemical substances. Regul Toxicol Pharmacol 15, 291-306.","DOI":"10.1016\/0273-2300(92)90040-G"},{"key":"46","unstructured":"46) International Commission on Radiological Protection (2002) Reference values for regional deposition. In: Annals of the ICRP. ICRP supporting guidance 3. Guide for the practical application of the ICRP human respiratory tract model, Valentin J (Ed.), 91-2, Pergamon (Elsevier), Oxford."},{"key":"47","unstructured":"47) Pinkerton KE, Gehr P, Crapo JD (1991) Architecture and cellular compositiom of the air-blood barrier. In: Treatise on pulmonary toxicology. Vol. 1. Comparative biology of the normal lung, Parent RA (Ed.), 121-8. CRC Press, Boca Raton."}],"container-title":["Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/indhealth\/48\/6\/48_MS1129\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T15:30:26Z","timestamp":1621524626000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/indhealth\/48\/6\/48_MS1129\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2486\/indhealth.ms1129","relation":{},"ISSN":["0019-8366","1880-8026"],"issn-type":[{"value":"0019-8366","type":"print"},{"value":"1880-8026","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}