{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:24:10Z","timestamp":1769041450022,"version":"3.49.0"},"reference-count":0,"publisher":"Sociedade Portuguesa de Estomatologia e Medicina Dentaria (SPEMD)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j.rpemd"],"published-print":{"date-parts":[[2025,12,30]]},"abstract":"<jats:p>Objectives: To evaluate whether periodontal disease is more prevalent in adults diagnosed\nwith Alzheimer's disease compared to adults without the condition.\nMethods: A total of 72 individuals were included in the study: 36 patients diagnosed with\nAlzheimer's disease (test group) and 36 matched individuals without Alzheimer's disease\n(control group). The diagnosis of periodontal disease was established through a comprehensive periodontal assessment. Additionally, a microbiological analysis of subgingival plaque\nsamples was conducted to detect the main periodontal pathogens.\nResults: Statistically significant differences were observed in periodontitis extent between\nthe two groups: 82.4% of patients in the test group and 56.3% in the control group presented generalized periodontitis. No association was found between the stage and extent of\nperiodontitis and the severity of Alzheimer's disease. Furthermore, no significant associations were observed between the number of years since Alzheimer's diagnosis and periodontal parameters, including the stage (p=0.659), extent (p=0.551), and grade of periodontitis (p=0.769). Prevotella intermedia was found in 25% of the test group and 5.6% of the control\ngroup (p=0.022). Campylobacter rectus appeared in 16.7% of the cases, with a significant difference between groups (p=0.011). Fusobacterium nucleatum was more common in the control\ngroup (75%) than in the test group (27.8%), with a significant difference (p&lt;0.001). Eikenella\ncorrodens was detected only in the control group (22.2%) (p=0.005).\nConclusions: Although the overall prevalence of periodontitis was similar between groups,\nindividuals with Alzheimer\u2019s disease tended to present a greater extent of generalized periodontitis.<\/jats:p>","DOI":"10.24873\/j.rpemd.2025.12.1555","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:48:52Z","timestamp":1768988932000},"page":"167-174","source":"Crossref","is-referenced-by-count":0,"title":["Association between periodontal disease and Alzheimer\u2019s disease: A cross-sectional study"],"prefix":"10.24873","volume":"66","author":[{"name":"Faculty of Dental Medicine, University of Lisbon, Lisbon, Portugal","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-1661","authenticated-orcid":false,"given":"Vanessa","family":"Rodrigues","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-5955","authenticated-orcid":false,"given":"M\u00f3nica","family":"Amorim","sequence":"additional","affiliation":[]},{"name":"Faculty of Dental Medicine, University of Lisbon, Lisbon, Portugal","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-2267","authenticated-orcid":false,"given":"Gil","family":"Alcoforado","sequence":"additional","affiliation":[]},{"name":"Egas Moniz School of Health and Science, Almada, Portugal","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-2059","authenticated-orcid":false,"given":"Susana","family":"Noronha","sequence":"additional","affiliation":[]},{"name":"Faculty of Dental Medicine, University of Lisbon, Lisbon, Portugal","sequence":"additional","affiliation":[]}],"member":"10497","published-online":{"date-parts":[[2025,12,30]]},"container-title":["Revista Portuguesa de Estomatologia, Medicina Dent\u00e1ria e Cirurgia Maxilofacial"],"original-title":[],"link":[{"URL":"https:\/\/revista.spemd.pt\/article_full\/2507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:48:53Z","timestamp":1768988933000},"score":1,"resource":{"primary":{"URL":"https:\/\/revista.spemd.pt\/article\/2507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,30]]},"published-print":{"date-parts":[[2025,12,30]]}},"URL":"https:\/\/doi.org\/10.24873\/j.rpemd.2025.12.1555","relation":{},"ISSN":["1646-2890","1647-6700"],"issn-type":[{"value":"1646-2890","type":"print"},{"value":"1647-6700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]}}}