{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:38:17Z","timestamp":1780378697906,"version":"3.54.1"},"reference-count":45,"publisher":"Discover STM Publishing Ltd.","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.sudanjp.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sudan J Paed"],"abstract":"<jats:p>Nutrition in the postnatal period is essential to achieve optimal growth and maintain biochemical normality. Feeding growth restricted premature neonates remains a big challenge for neonatologists. The choice of milk is one of the biggest challenges. Breast milk is recommended although feeding with preterm formulas can ensure a more consistent delivery of optimal levels of nutrients. The timing of introduction of feeds and the rate of advancement of those feeds in preterm infants are both topics of significant controversy. Early feeding is advantageous because it improves the functional adaptation of the gastrointestinal tract and reduces the duration of total parenteral nutrition. A faster rate of advancement will also reduce the duration of parenteral nutrition. Despite this, enteral feeding is often delayed and is often slowly increased in high risk infants because of a possible increased risk of necrotising enterocolitis (NEC). Growth restricted neonates are at increased risk of developing NEC due to a combination of antenatal and postnatal disturbances in gut perfusion. If enteral feeding is introduced earlier and advanced more quickly this may lead to increased risk of NEC, but slower feeds extends the duration of parenteral nutrition, and its risks, and may have adverse consequences for survival, growth and development. Premature infants pose a significant nutritional challenge. Overall, we would suggest preferential use of human milk, early minimal enteral feeds and standardized feeding protocols with cautious advancements of feeds to facilitate gastrointestinal adaptation and reduce the risk of NEC, but further research is needed.<\/jats:p>","DOI":"10.24911\/sjp.106-1519511375","type":"journal-article","created":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T06:26:31Z","timestamp":1546323991000},"page":"5-14","source":"Crossref","is-referenced-by-count":11,"title":["Feeding growth restricted premature neonates: a challenging perspective"],"prefix":"10.24911","author":[{"given":"Siba","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Kirkham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hawton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mannix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10538","published-online":{"date-parts":[[2018]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Corvaglia L, Fantini MP, Aceti A, Gibertoni D, Rucci P, Baronciani D, et al. 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J Pediatr. 2010;156:562.7; https:\/\/doi.org\/10.1016\/j.jpeds.2009.10.040","DOI":"10.1016\/j.jpeds.2009.10.040"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Brown JV, Embleton ND, Harding JE, McGuire W. Multi-nutrient fortification of human milk for preterm infants. Cochrane Database Syst Rev. 2016;5:CD000343;. https:\/\/doi.org\/10.1002\/14651858.CD000343.pub3.","DOI":"10.1002\/14651858.CD000343.pub3"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Narayanan I, Prakash K, Prabhakar AK, Gujral VV. A planned prospective evaluation of the anti-infective property of varying quantities of expressed human milk. Acta Paediatr Scand. 1982;71:441.5; https:\/\/doi.org\/10.1111\/j.1651-2227.1982.tb09449.x","DOI":"10.1111\/j.1651-2227.1982.tb09449.x"},{"key":"ref18","unstructured":"Narayanan I. Human milk in the developing world: to bank or not to bank? Indian Pediatr. 1982;19:395.9."},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Oddie SJ, Young L, McGuire W. Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants. Cochrane Database Syst Rev. 2017;8:CD001241; https:\/\/doi.org\/10.1002\/14651858.CD001241.pub7","DOI":"10.1002\/14651858.CD001241.pub7"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Graziano P, Tauber K, Cummings J, Graffunder E, Horgan MJ. Prevention of postnatal growth restriction by the implementation of an evidence-based premature infant feeding bundle. J Perinatol. 2015;35:642.9; https:\/\/doi.org\/10.1038\/jp.2015.35","DOI":"10.1038\/jp.2015.35"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Arnon S, Sulam D, Konikoff F, Regev RH, Litmanovitz I, Naftali T. Very early feeding in stable small for gestational age preterm infants: a randomized clinical trial. 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Available from: https:\/\/registration.pas \u2010meeting.org\/2017\/reports\/rptPAS17_Abstracts.asp"},{"key":"ref31","unstructured":"Salhotra A, Ramji S. Slow versus fast enteral feed advancement in very low birth weight infants: a randomized control trial. Indian Pediatr. 2004;41:435.41."},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Murguia-Peniche T, Kirsten GF. Meeting the challenge of providing neonatal nutritional care to very or extremely low birth weight infants in low-resource settings. World Rev Nutr Diet. 2014;110:278.96; https:\/\/doi.org\/10.1159\/000358476","DOI":"10.1159\/000358476"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Premji SS, Chessel L. Continuous nasogastric milk feeding versus intermittent bolus milk feeding for premature infants less than 1500 grams. Cochrane Database Syst Rev. 2011;11:CD001819; https:\/\/doi.org\/10.1002\/14651858.CD001819.pub2","DOI":"10.1002\/14651858.CD001819.pub2"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Hay Jr WW. Strategies for feeding the preterm infant. Neonatology. 2008;94:245-54; https:\/\/doi.org\/10.1159\/000151643","DOI":"10.1159\/000151643"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Ehrenkranz RA. Extrauterine growth restriction: is it preventable? J Pediatr (Rio J). 2014;90:1-3; https:\/\/doi.org\/10.1016\/j.jped.2013.10.003","DOI":"10.1016\/j.jped.2013.10.003"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Patole SK, de Klerk N. Impact of standardized feeding regimens on incidence of neonatal necrotising enterocolitis: a systematic review and meta-analysis of observational studies. Arch Dis Child Fetal Neonatal Ed. 2005;90:F147-51; https:\/\/doi.org\/10.1136\/adc.2004.059741","DOI":"10.1136\/adc.2004.059741"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Gordon PV, Young ML, Marshall DD. Focal small bowel perforation: An adverse effect of early postnatal dexamethasone therapy in extremely preterm infants. J Perinatal. 2001;21:156-60 https:\/\/doi.org\/10.1038\/sj.jp.7200520","DOI":"10.1038\/sj.jp.7200520"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Hall NJ, Eaton S, Peters MJ, Hiorns MP, Alexander N, Azzopardi DV, et al. Mild controlled hypothermia in preterm neonates with advanced necrotizing enterocolitis. Pediatrics. 2010;125:e300-8; https:\/\/doi.org\/10.1542\/peds.2008-3211","DOI":"10.1542\/peds.2008-3211"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"ELFIN Trial Investigators Group. Lactoferrin immunoprophylaxis for very preterm infants. Arch Dis Child Fetal Neonatal Ed. 2013;98:F2-4; https:\/\/ doi.org\/10.1136\/archdischild-2011-301273","DOI":"10.1136\/archdischild-2011-301273"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Greer FR, Olsen IE. How Fast Should the Preterm Infant Grow? Curr Pediatr Rep. 2013;1:240-6; https:\/\/doi.org\/10.1007\/s40124-013-0029-1","DOI":"10.1007\/s40124-013-0029-1"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Pammi M, Suresh G. Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2017;6:CD007137; https:\/\/doi.org\/10.1002\/14651858.CD007137.pub5","DOI":"10.1002\/14651858.CD007137.pub5"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Embleton ND, Berrington JE, Dorling J, Ewer AK, Juszczak E, Kirby JA, et al. Mechanisms affecting the gut of preterm infants in enteral feeding trials. 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