{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:54:21Z","timestamp":1792061661120,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":2054,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chinese Medical Sciences Journal"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.24920\/003594","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T01:32:47Z","timestamp":1593480767000},"page":"215-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Dihydrotestosterone on Costimulatory Molecules in a Mouse Model of Graves' Disease"],"prefix":"10.1016","volume":"35","author":[{"given":"Lianye","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.24920\/003594_bib1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.autrev.2014.01.013","article-title":"Diagnosis and classification of Graves' disease","volume":"4-5","author":"Menconi","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"64","key":"10.24920\/003594_bib2","first-page":"189","article-title":"Relationship between CTLA-4 and CD28 molecule expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves' disease","volume":"4","author":"Bossowski","year":"2005","journal-title":"Horm Res"},{"issue":"31","key":"10.24920\/003594_bib3","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.dci.2007.01.008","article-title":"IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA-4, PDCD1 and BTLA) receptors","volume":"10","author":"Garapati","year":"2007","journal-title":"Dev Comp Immunol"},{"issue":"55","key":"10.24920\/003594_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12020-016-1096-1","article-title":"CD28\/CTLA-4\/ICOS haplotypes confers susceptibility to Graves' disease and modulates clinical phenotype of disease","volume":"1","author":"Pawlak-Adamska","year":"2017","journal-title":"Endocrine"},{"key":"10.24920\/003594_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/269756","article-title":"Coinhibitory molecules in autoimmune diseases","volume":"2012","author":"Watanabe","year":"2012","journal-title":"Clin Dev Immunol"},{"issue":"144","key":"10.24920\/003594_bib6","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.4049\/jimmunol.144.5.1646","article-title":"CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes","volume":"5","author":"Turka","year":"1990","journal-title":"J Immunol"},{"issue":"81","key":"10.24920\/003594_bib7","first-page":"4137","article-title":"Lack of B7-1\/BB1 and B7-2\/B70 expression on thyrocytes of patients with Graves' disease. Delivery of costimulatory signals from bystander professional antigen-presenting cells","volume":"11","author":"Matsuoka","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"32","key":"10.24920\/003594_bib8","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/1521-4141(200204)32:4<972::AID-IMMU972>3.0.CO;2-M","article-title":"The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance","volume":"4","author":"Eagar","year":"2002","journal-title":"Eur J Immunol"},{"issue":"397","key":"10.24920\/003594_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/16717","article-title":"ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28","volume":"6716","author":"Hutloff","year":"1999","journal-title":"Nature"},{"issue":"173","key":"10.24920\/003594_bib10","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.4049\/jimmunol.173.3.1779","article-title":"ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells","volume":"3","author":"Wassink","year":"2004","journal-title":"J Immunol"},{"issue":"11","key":"10.24920\/003594_bib11","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1002\/j.1460-2075.1992.tb05481.x","article-title":"Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death","volume":"11","author":"Ishida","year":"1992","journal-title":"EMBO J"},{"issue":"28","key":"10.24920\/003594_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1385\/IR:28:1:49","article-title":"Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation","volume":"1","author":"Carter","year":"2003","journal-title":"Immunol Res"},{"issue":"4","key":"10.24920\/003594_bib13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ni944","article-title":"BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1","volume":"7","author":"Watanabe","year":"2003","journal-title":"Nat Immunol"},{"issue":"6","key":"10.24920\/003594_bib14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/ni1144","article-title":"B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator","volume":"1","author":"Sedy","year":"2005","journal-title":"Nat Immunol"},{"issue":"415","key":"10.24920\/003594_bib15","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/415536a","article-title":"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease","volume":"6871","author":"Monney","year":"2002","journal-title":"Nature"},{"issue":"6","key":"10.24920\/003594_bib16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity","volume":"12","author":"Zhu","year":"2005","journal-title":"Nat Immunol"},{"issue":"104","key":"10.24920\/003594_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: integrating mammalian biology","volume":"4","author":"Locksley","year":"2001","journal-title":"Cell"},{"issue":"11","key":"10.24920\/003594_bib18","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1002\/j.1460-2075.1992.tb05530.x","article-title":"The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity","volume":"12","author":"Hollenbaugh","year":"1992","journal-title":"EMBO J"},{"issue":"30","key":"10.24920\/003594_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.it.2009.01.004","article-title":"CD154 and its receptors in inflammatory vascular pathologies","volume":"4","author":"Hassan","year":"2009","journal-title":"Trends Immunol"},{"key":"10.24920\/003594_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.immunol.23.021704.115839","article-title":"TNF\/TNFR family members in costimulation of T cell responses","volume":"23","author":"Watts","year":"2005","journal-title":"Annu Rev Immunol"},{"issue":"165","key":"10.24920\/003594_bib21","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.4049\/jimmunol.165.6.3043","article-title":"The 0X40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion","volume":"6","author":"Gramaglia","year":"2000","journal-title":"J Immunol"},{"issue":"50","key":"10.24920\/003594_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cyto.2010.03.005","article-title":"Cytokines, thyroid diseases and thyroid cancer","volume":"3","author":"Lumachi","year":"2010","journal-title":"Cytokine"},{"issue":"136","key":"10.24920\/003594_bib23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4049\/jimmunol.136.1.143","article-title":"Beneficial effect of testosterone in the treatment of chronic autoimmune thyroiditis in rats","volume":"1","author":"Ansar","year":"1986","journal-title":"J Immunol"},{"issue":"1","key":"10.24920\/003594_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0896-8411(88)90081-9","article-title":"The role of testosterone in spontaneous autoimmune thyroiditis of Obese strain (OS) chickens","volume":"1","author":"Fassler","year":"1988","journal-title":"J Autoimmun"},{"issue":"141","key":"10.24920\/003594_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1677\/joe.0.1410309","article-title":"Intrathyroidal cytokine gene expression profiles in autoimmune thyroiditis","volume":"2","author":"Paschke","year":"1994","journal-title":"J Endocrinol"},{"issue":"202","key":"10.24920\/003594_bib26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1677\/JOE-09-0089","article-title":"Immunization with thyroglobulin induces Graves'-like disease in mice","volume":"2","author":"Endo","year":"2009","journal-title":"J Endocrinol"},{"issue":"26","key":"10.24920\/003594_bib27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/thy.2015.0620","article-title":"The influence of dihydrotestosterone on the development of Graves' disease in female BALB\/c mice","volume":"3","author":"Liu","year":"2016","journal-title":"Thyroid"},{"issue":"111","key":"10.24920\/003594_bib28","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1172\/JCI200317069","article-title":"The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim","volume":"12","author":"Chen","year":"2003","journal-title":"J Clin Invest"},{"issue":"170","key":"10.24920\/003594_bib29","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.4049\/jimmunol.170.7.3522","article-title":"Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine","volume":"7","author":"Nagayama","year":"2003","journal-title":"J Immunol"},{"issue":"96","key":"10.24920\/003594_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.exer.2011.12.016","article-title":"Influence of sex hormones and genetic predisposition in Sjogren's syndrome: a new clue to the immunopathogenesis of dry eye disease","volume":"1","author":"Mostafa","year":"2012","journal-title":"Exp Eye Res"},{"issue":"152","key":"10.24920\/003594_bib31","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1210\/en.2010-0737","article-title":"Induction of murine neonatal tolerance against Graves' disease using recombinant adenovirus expressing the TSH receptor A-subunit","volume":"3","author":"Wu","year":"2011","journal-title":"Endocrinology"},{"issue":"50","key":"10.24920\/003594_bib32","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1194\/jlr.M900101-JLR200","article-title":"Docosahexaenoic acid reduces suppressive and migratory functions of CD4+CD25+ regulatory T-cells","volume":"12","author":"Yessoufou","year":"2009","journal-title":"J Lipid Res"},{"issue":"45","key":"10.24920\/003594_bib33","first-page":"603","article-title":"Therapeutic effects of B and T lymphocyte attenuator extracellular domain and heat shock protein 70 antigen peptide on cervical cancer in mouse model","volume":"8","author":"Han","year":"2010","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"256","key":"10.24920\/003594_bib34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cellimm.2009.01.008","article-title":"Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism","volume":"l-2","author":"Bishop","year":"2009","journal-title":"Cell Immunol"},{"issue":"13","key":"10.24920\/003594_bib35","doi-asserted-by":"crossref","first-page":"10113","DOI":"10.3390\/ijms130810113","article-title":"Quantitative expression of C-type lectin receptors in humans and mice","volume":"8","author":"Lech","year":"2012","journal-title":"Int J Mol Sci"},{"issue":"22","key":"10.24920\/003594_bib36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/intimm\/dxq020","article-title":"CD28 expression redefines thymocyte development during the pre-T to DP transition","volume":"5","author":"Teague","year":"2010","journal-title":"Int Immunol"},{"issue":"125","key":"10.24920\/003594_bib37","first-page":"2188","article-title":"Repressor of GATA-3 can negatively regulate the expression of T cell cytokines through modulation on inducible costimulator","volume":"12","author":"Zang","year":"2012","journal-title":"Chin Med J (Engl)"},{"issue":"179","key":"10.24920\/003594_bib38","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.4049\/jimmunol.179.3.1760","article-title":"0X40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Spl\/Sp3, YY1, and NF-kappa B binding sites","volume":"3","author":"Tone","year":"2007","journal-title":"J Immunol"},{"issue":"39","key":"10.24920\/003594_bib39","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1002\/eji.200839163","article-title":"In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells","volume":"8","author":"Vavassori","year":"2009","journal-title":"Eur J Immunol"},{"issue":"109","key":"10.24920\/003594_bib40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1172\/JCI0214941","article-title":"Activation and inhibition of lymphocytes by costimulation","volume":"3","author":"Frauwirth","year":"2002","journal-title":"J Clin Invest"},{"issue":"63","key":"10.24920\/003594_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1507\/endocrj.EJ15-0435","article-title":"Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases","volume":"1","author":"Yoshie","year":"2016","journal-title":"Endocr J"},{"issue":"253","key":"10.24920\/003594_bib42","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00417-014-2902-1","article-title":"CD40 ligand induces expression of vascular cell adhesion molecule 1 and E-selectin in orbital fibroblasts from patients with Graves' orbitopathy","volume":"4","author":"Wang","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"28","key":"10.24920\/003594_bib43","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1385\/IR:28:1:39","article-title":"Immune regulation by novel costimulatory molecules","volume":"1","author":"Dong","year":"2003","journal-title":"Immunol Res"},{"issue":"26","key":"10.24920\/003594_bib44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/intimm\/dxt056","article-title":"The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease","volume":"7","author":"Kaneyama","year":"2014","journal-title":"Int Immunol"},{"issue":"127","key":"10.24920\/003594_bib45","first-page":"78","article-title":"Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis","volume":"1","author":"Sekl","year":"2008","journal-title":"Clin Immunol"},{"issue":"186","key":"10.24920\/003594_bib46","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.4049\/jimmunol.1001958","article-title":"Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: evidence for a direct role of testosterone on regulatory T cell expansion","volume":"9","author":"Fijak","year":"2011","journal-title":"J Immunol"}],"container-title":["Chinese Medical Sciences Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001929420300444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001929420300444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cmsj.cams.cn\/previewFile?fileName=Effect%20of%20Dihydrotestosterone%20on%20CostimulatoryMolecules%20in%20a%20Mouse%20Model%20of%20Graves%E2%80%99%20Disease&id=56555684&type=pdf&lang=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:32:21Z","timestamp":1792060341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001929420300444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1001929420300444"],"URL":"https:\/\/doi.org\/10.24920\/003594","relation":{},"ISSN":["1001-9294"],"issn-type":[{"value":"1001-9294","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Dihydrotestosterone on Costimulatory Molecules in a Mouse Model of Graves' Disease","name":"articletitle","label":"Article Title"},{"value":"Chinese Medical Sciences Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.24920\/003594","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 Chinese Academy Medical Sciences. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}