{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:17:09Z","timestamp":1747210629504,"version":"3.40.5"},"reference-count":0,"publisher":"Sociedade Portuguesa de Medicina Interna","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RPMI"],"abstract":"<jats:p>A pandemia pela COVID-19 \u00e9 um problema grave de Sa\u00fade Publica mundial, para a qual n\u00e3o existe tratamento eficaz. Cerca de 20%-33% dos doentes s\u00e3o admitidos em Unidades de Cuidados Intensivos e nestes a taxa de mortalidade \u00e9 superior a 25%. A morte causada diretamente pela COVID-19 resulta, na maioria dos casos, de uma resposta hiperinflamat\u00f3ria inapropriada \u00e0 infe\u00e7\u00e3o, com liberta\u00e7\u00e3o de citocinas. Pelo paralelismo com outras doen\u00e7as inflamat\u00f3rias imunomediadas, os autores fizeram uma revis\u00e3o cr\u00edtica dos mecanismos fisiopatol\u00f3gicos envolvidos e potenciais situa\u00e7\u00f5es onde a utiliza\u00e7\u00e3o de imunomoduladores, numa estreita janela de oportunidade, pode vir a mudar o progn\u00f3stico de alguns doentes.<\/jats:p>","DOI":"10.24950\/rspmi\/p.vista\/covid19\/79\/20\/chp\/s\/2020","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T11:04:55Z","timestamp":1590404695000},"page":"35-41","source":"Crossref","is-referenced-by-count":0,"title":["Janela de Oportunidade para a Imunomodula\u00e7\u00e3o na COVID-19"],"prefix":"10.24950","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2956-1966","authenticated-orcid":false,"given":"Raquel","family":"Faria","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-5741","authenticated-orcid":false,"given":"Graziela","family":"Carvalheiras","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-7075","authenticated-orcid":false,"given":"Rute","family":"Alves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-0250","authenticated-orcid":false,"given":"Daniel","family":"G. Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-6932","authenticated-orcid":false,"given":"Mariana","family":"Brand\u00e3o","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-4865","authenticated-orcid":false,"given":"Pedro","family":"Vita","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-6723","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Marinho","sequence":"additional","affiliation":[]}],"member":"10574","published-online":{"date-parts":[[2021,12,21]]},"container-title":["Medicina Interna"],"original-title":[],"link":[{"URL":"https:\/\/revista.spmi.pt\/index.php\/rpmi\/article\/download\/218\/138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revista.spmi.pt\/index.php\/rpmi\/article\/download\/218\/138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T22:23:50Z","timestamp":1640125430000},"score":1,"resource":{"primary":{"URL":"https:\/\/revista.spmi.pt\/index.php\/rpmi\/article\/view\/218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.24950\/rspmi\/p.vista\/covid19\/79\/20\/chp\/s\/2020","relation":{},"ISSN":["2183-9980","0872-671X"],"issn-type":[{"type":"electronic","value":"2183-9980"},{"type":"print","value":"0872-671X"}],"subject":[],"published":{"date-parts":[[2021,12,21]]}}}