{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:33:02Z","timestamp":1788798782581,"version":"build-2803163510"},"reference-count":0,"publisher":"Hacettepe University Institute of Child Health","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Pediatr"],"abstract":"<jats:p>\n\t\t\t\t\tBackground. Experimental studies have addressed the role of oxidant stress in the pathogenesis of Hemophilia A. This study aimed to determine whether dynamic thiol-disulfide exchange, a recently recognized cellular defense system against oxidative stress, is disturbed in children with hemophilia A.\n\t\t\t\t\tMethods. This prospective case control study included male children with hemophilia A (n=62) and randomly selected healthy age and sex-matched controls (n=62). Serum native thiol, total thiol and disulfide levels were analyzed with a novel spectrophotometric method. Ratios of disulfide\/total thiol, disulfide\/native thiol, and native\/total thiol were calculated. Statistical comparisons were made using the independent samples t-test or the Mann-Whitney U test, according to whether the data were normally distributed or not.\n\t\t\t\t\tResults. Serum native thiol (385.0 &amp;#xb1; 35.9 versus 418.0 &amp;#xb1; 44.3, respectively; p &amp;amp;lt; 0.001) and total thiol (424.2 &amp;#xb1; 38.7 versus 458.0 &amp;#xb1; 46.3, respectively; p &amp;amp;gt; 0.001) levels were significantly lower in children with Hemophilia A compared to controls. Children with hemophilia A had significantly lower serum native thiol to total thiol ratio than controls (p=0.024). Serum disulfide levels of children with hemophilia A were close to controls (19.2 [17.6- 22.1] versus 19.8 [17.8- 21.2]), respectively; p=0.879) whereas disulfide to native thiol ratio (p=0.024) and disulfide to total thiol ratio (p=0.024) were significantly higher.\n\t\t\t\t\tConclusions. Decreased antioxidant capacity with levels of serum native thiol and total thiol in children with hemophilia A might be regarded as evidence for the disturbance of thiol\/disulfide balance. Antioxidant treatment can be a future target of therapy in children with hemophilia A.\n\t\t\t\t<\/jats:p>","DOI":"10.24953\/turkjped.2022.73","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T06:33:09Z","timestamp":1666765989000},"page":"876-881","source":"Crossref","is-referenced-by-count":1,"title":["Decreased antioxidant capacity with serum native thiol and total thiol levels in children with hemophilia A: a prospective case-control study"],"prefix":"10.24953","volume":"64","author":[{"given":"Ser\u00e7in","family":"Ta\u015far","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe G\u00fcl","family":"G\u00fcven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbur\u00e7e","family":"Olga\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Ne\u015felio\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"Alio\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10580","published-online":{"date-parts":[[2022,10,25]]},"container-title":["The Turkish Journal of Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/turkjpediatr.org\/article\/download\/220\/220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/turkjpediatr.org\/article\/download\/220\/220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T22:23:25Z","timestamp":1712355805000},"score":1,"resource":{"primary":{"URL":"https:\/\/turkjpediatr.org\/article\/view\/220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,10,28]]}},"URL":"https:\/\/doi.org\/10.24953\/turkjped.2022.73","relation":{},"ISSN":["2791-6421","0041-4301"],"issn-type":[{"value":"2791-6421","type":"electronic"},{"value":"0041-4301","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,25]]}}}