{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:03:35Z","timestamp":1765422215000},"publisher-location":"California","reference-count":0,"publisher":"International Joint Conferences on Artificial Intelligence Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Precise medicine recommendations provide more effective treatments and cause fewer drug side effects. A key step is to understand the mechanistic relationships among drugs, targets, and diseases. Tensor-based models have the ability to explore relationships of drug-target-disease based on large amount of labeled data. However, existing tensor models fail to capture complex nonlinear dependencies among tensor data. In addition, rich medical knowledge are far less studied, which may lead to unsatisfied results. Here we propose a Neural Tensor Network (NeurTN) to assist personalized medicine treatments. NeurTN seamlessly combines tensor algebra and deep neural networks, which offers a more powerful way to capture the nonlinear relationships among drugs, targets, and diseases. To leverage medical knowledge, we augment NeurTN with geometric neural networks to capture the structural information of both drugs\u2019 chemical structures and targets\u2019 sequences. Extensive experiments on real-world datasets demonstrate the effectiveness of the NeurTN model.<\/jats:p>","DOI":"10.24963\/ijcai.2020\/477","type":"proceedings-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T12:12:10Z","timestamp":1594210330000},"page":"3452-3458","source":"Crossref","is-referenced-by-count":15,"title":["Learning Data-Driven Drug-Target-Disease Interaction via Neural Tensor Network"],"prefix":"10.24963","author":[{"given":"Huiyuan","family":"Chen","sequence":"first","affiliation":[{"name":"Case Western Reserve University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Case Western Reserve University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10584","event":{"number":"28","sponsor":["International Joint Conferences on Artificial Intelligence Organization (IJCAI)"],"acronym":"IJCAI-PRICAI-2020","name":"Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}","start":{"date-parts":[[2020,7,11]]},"theme":"Artificial Intelligence","location":"Yokohama, Japan","end":{"date-parts":[[2020,7,17]]}},"container-title":["Proceedings of the Twenty-Ninth International Joint Conference on Artificial Intelligence"],"original-title":[],"deposited":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T02:15:24Z","timestamp":1594260924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijcai.org\/proceedings\/2020\/477"}},"subtitle":[],"proceedings-subject":"Artificial Intelligence Research Articles","short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.24963\/ijcai.2020\/477","relation":{},"subject":[],"published":{"date-parts":[[2020,7]]}}}