{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:14:46Z","timestamp":1777385686225,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Rhinology"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>\n                    The efficacy of aqueous suspensions of budesonide nasal spray and fluticasone propionate nasal spray, in the treatment of seasonal allergic rhinitis, was compared in a large, placebo-controlled, two-center study. A 1-week baseline period was followed by a 4- to 6-week treatment period during which 635 adult patients, aged 18\u201372 years, were randomized to receive either placebo, budesonide 128 \u03bcg, or 256 \u03bcg once daily, or fluticasone propionate, 200 \u03bcg once daily. Nasal and eye symptoms, overall treatment efficacy and safety assessments were made during the study period. Combined, as well as individual, nasal symptoms were significantly improved in all three active treatment groups compared with placebo therapy. Treatment with 256 \u03bcg\/day of budesonide was found to be significantly more effective in reducing the sneezing score compared with 200 \u03bcg\/day of fluticasone propionate. Analysis of symptom scores on days when the pollen count was greater than 10 grains\/m\n                    <jats:sup>3<\/jats:sup>\n                    revealed 256 \u03bcg\/day of budesonide therapy to be significantly more effective in reducing combined symptom scores as well as the individual scores for sneezing and runny nose, compared with 200 \u03bcg\/day fluticasone propionate. The higher dose of budesonide (256 \u03bcg\/day) was also more effective than the lower dose (128 \u03bcg\/day) in reducing sneezing scores and statistical significance was almost reached for the reduction in combined symptom and runny nose scores. Substantial or total control of symptoms was achieved by 31.4%, 85.3%, 88.4%, and 81.9% of patients receiving placebo, 128 \u03bcg\/day of budesonide, 256 \u03bcg\/day of budesonide, and 200 \u03bcg\/day of fluticasone propionate, respectively. The incidence of adverse events was low in all treatment groups. In conclusion, both budesonide and fluticasone propionate treatments were effective and well-tolerated in the treatment of seasonal allergic rhinitis. However, 256 \u03bcg\/day of budesonide tended to be more effective than 200 \u03bcg\/day of fluticasone propionate and 128 \u03bcg\/day of budesonide, especially when patients were exposed to a higher pollen load.\n                  <\/jats:p>","DOI":"10.2500\/105065897781446658","type":"journal-article","created":{"date-parts":[[2007,8,4]],"date-time":"2007-08-04T14:09:57Z","timestamp":1186236597000},"page":"323-330","source":"Crossref","is-referenced-by-count":25,"title":["A Comparison of Aqueous Suspensions of Budesonide Nasal Spray (128 \u03bcg and 256 \u03bcg Once Daily) and Fluticasone Propionate Nasal Spray (200 \u03bcg Once Daily) in the Treatment of Adult Patients with Seasonal Allergic Rhinitis"],"prefix":"10.1177","volume":"11","author":[{"given":"Martin A.","family":"Stern","sequence":"first","affiliation":[{"name":"Midlands Asthma and Allergy Research Association (MAARA), Leicester General Hospital, Leicester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Dahl","sequence":"additional","affiliation":[{"name":"Lungemedicinsk afdeling, Aarhus Kommunehospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars P.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Lungemedicinsk afdeling, Aarhus Kommunehospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Lungemedicinsk afdeling, Aarhus Kommunehospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Schrewelius","sequence":"additional","affiliation":[{"name":"Clinical Research & Development, Astra Draco AB, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,7,1]]},"reference":[{"key":"bibr1-105065897781446658","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198507113130201"},{"key":"bibr2-105065897781446658","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1398-9995.1994.tb00765.x","volume":"49","author":"International Rhinitis Management Working Group.","year":"1994","journal-title":"Allergy"},{"key":"bibr3-105065897781446658","first-page":"129","volume-title":"Respiratory allergy: Advances in clinical immunology and pulmonary medicine.","author":"Brattsand R.","year":"1993"},{"key":"bibr4-105065897781446658","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199244030-00007"},{"key":"bibr5-105065897781446658","first-page":"1","volume":"121","author":"Balle V.","year":"1991","journal-title":"Schweiz Med Wochenschr"},{"key":"bibr6-105065897781446658","first-page":"148","volume":"1","author":"Penttila 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