{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:24:46Z","timestamp":1790749486745,"version":"4.1.0"},"reference-count":0,"publisher":"Oceanside Publications Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Food protein-induced allergic proctocolitis (FPIAP) is a non\u2010immunoglobulin E (IgE) mediated food allergy that typically presents with blood-mixed mucoid stool.  <jats:bold>Objective:<\/jats:bold> To identify the predictors that affect the tolerance development\n in infants with FPAIP and laboratory as well as clinical differences between patients with early and with late tolerance.  <jats:bold>Methods:<\/jats:bold> A total of 185 infants with FPIAP were included. The patients were grouped and analyzed based on laboratory tests and clinical characteristics.\n  <jats:bold>Results:<\/jats:bold> The median (interquartile range [IQR]) age of onset of symptoms was 2.0 months (1.0\u20103.0 months). Symptoms began in severe cases in patients (n = 23) at a younger median (IQR) age (1.5 months [0.7\u20102.0 months]) than the group with nonsevere presentation\n (median 2.0 months [IQR 1.5\u20103.0 months]) (p &lt; 0.001). The frequency of neutropenia (&lt;1500\/mm<jats:sup>3<\/jats:sup>) (p = 0.045) and eosinophilia (450 mm<jats:sup>3<\/jats:sup>) (p = 0.018) was increased in severe cases. Concomitant IgE-related food allergy (odds ratio [OR] 3.595 [95% confidence interval\n {CI}, 1.096\u201011.788], p = 0.035), non\u2010IgE-mediated multiple food allergy (OR 3.577 [95% CI, 1.595\u20108.018], p = 0.002), feeding with cow's milk\u2010based formula (at least once during infancy) (OR 2.517 [95% CI, 1.188\u20105.333], p = 0.016), and late complementary feeding\n (OR 5.438 [95% CI, 2.693\u201010.981], p &lt; 0.001) were the predictors for late tolerance development. The estimated optimal cutoff value for introduction of complementary foods for the resolution of allergy was 5.5 months, with 69.4% sensitivity, 74.4% specificity, and an area under the\n curve of 0.737 (95% CI, 0.626\u20100.812) (p &lt; 0.001).  <jats:bold>Conclusion:<\/jats:bold> This study showed that the early introduction of complementary feeding accelerates tolerance development in FPAIP. A longer duration of an elimination diet has no impact on the resolution of allergy.\n Physicians should consider conservative avoidance measures and earlier introduction of complementary feeding in FPIAP.<\/jats:p>","DOI":"10.2500\/aap.2020.41.190017","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T23:34:17Z","timestamp":1577748857000},"page":"e11-e18","source":"Crossref","is-referenced-by-count":32,"title":["Predictors for late tolerance development in food protein\u2010induced allergic proctocolitis"],"prefix":"10.2500","volume":"41","author":[{"given":"P\u0131nar Gur","family":"Cetinkaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Kahveci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00fcl","family":"Karaatmaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliha","family":"Esenboga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit Murat","family":"Sahiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent Enis","family":"Sekerel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Soyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1355","container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2020\/00000041\/00000001\/art00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T23:37:17Z","timestamp":1577835437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2020.41.190017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"alternative-id":["1088-5412(20200101)41:1L.11;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2020.41.190017","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}