{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T21:16:52Z","timestamp":1649107012035},"reference-count":0,"publisher":"Oceanside Publications Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p>The increasing availability of genetic testing for modern immunologists in the evaluation of immune diseases could provide a definite diagnosis in elusive cases. A 27-year-old white male patient presented to the clinic with recurrent sinopulmonary and cutaneous infections since childhood.\n The patient\u2019s mother had seronegative polyarthritis, and one of two sisters of the patient had chronic sinopulmonary infections. Serum immunoglobulins, immunoglobulin G (IgG) subclasses, lymphocyte subset markers, mannose-binding lectin, mitogen and antigen stimulation, bacteriophage\n study, and Streptococcus pneumoniae titers to 23 serotypes were all normal. B-cell phenotyping revealed a decrease in both nonswitched memory B cells (CD19<jats:sup>+<\/jats:sup>CD27<jats:sup>+<\/jats:sup>IgD<jats:sup>+<\/jats:sup>) and switched memory B-cells (CD19<jats:sup>+<\/jats:sup>CD27<jats:sup>+<\/jats:sup>IgD<jats:sup>\u2212<\/jats:sup>). Genetic\n testing and the improvement of clinical symptoms after IgG replacement led to the final diagnosis.<\/jats:p>","DOI":"10.2500\/aap.2020.41.190026","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T04:38:52Z","timestamp":1588826332000},"page":"218-223","source":"Crossref","is-referenced-by-count":0,"title":["A 27-year-old man with recurrent sinopulmonary and cutaneous infections"],"prefix":"10.2500","volume":"41","author":[{"given":"Shan Shan","family":"Wu","sequence":"first","affiliation":[{"name":"From the Department of Pulmonary and Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Sanan","sequence":"additional","affiliation":[{"name":"From the Department of Pulmonary and Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Schend","sequence":"additional","affiliation":[{"name":"From the Department of Pulmonary and Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Rowane","sequence":"additional","affiliation":[{"name":"Ohio University Heritage College of Osteopathic Medicine, Athens, Ohio, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Robert W.","family":"Hostoffer","sequence":"additional","affiliation":[{"name":"From the Department of Pulmonary and Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2020\/00000041\/00000003\/art00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T04:42:44Z","timestamp":1590554564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2020.41.190026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5,1]]}},"alternative-id":["1088-5412(20200501)41:3L.218;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2020.41.190026","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,1]]}}}