{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T11:16:02Z","timestamp":1716030962133},"reference-count":0,"publisher":"Oceanside Publications Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Terminal complement component deficiencies are risk factors for neisserial infections.  <jats:bold>Objective:<\/jats:bold> To review the clinical characteristics, the diagnosis and the management of patients with a terminal complement component deficiency. \n <jats:bold>Methods:<\/jats:bold> Pertinent articles were selected and reviewed in relation to a case presentation of C6 deficiency.  <jats:bold>Results:<\/jats:bold> A case of a 56-year old patient with a history of meningitis, chronic rash, and C6 deficiency was presented, followed by discussion of clinical\n characteristics, diagnosis, and management of terminal complement component deficiencies. Clinical pearls and pitfalls were reviewed for the practicing allergist\/immunologist and fellow-in-training.  <jats:bold>Conclusion:<\/jats:bold> C6 deficiency is the most common terminal complement component\n deficiency and can present later in age with N. meningitidis infections. Patients can be screened for terminal complement component deficiency by checking CH50.<\/jats:p>","DOI":"10.2500\/aap.2020.41.200039","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T04:33:55Z","timestamp":1598934835000},"page":"386-388","source":"Crossref","is-referenced-by-count":2,"title":["Clinical implications of C6 complement component deficiency"],"prefix":"10.2500","volume":"41","author":[{"given":"Christine K.","family":"Rauscher","sequence":"first","affiliation":[{"name":"From the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merritt L.","family":"Fajt","sequence":"additional","affiliation":[{"name":"From the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie","family":"Bryk","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej A.","family":"Petrov","sequence":"additional","affiliation":[{"name":"From the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2020\/00000041\/00000005\/art00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T04:47:46Z","timestamp":1600836466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2020.41.200039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9,1]]}},"alternative-id":["1088-5412(20200901)41:5L.386;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2020.41.200039","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}