{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:25:46Z","timestamp":1768634746868,"version":"3.49.0"},"reference-count":0,"publisher":"Oceanside Publications Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"Background:<\/jats:bold> The European Academy of Allergy and Clinical Immunology guidelines, strongly recommended allergen immunotherapy (AIT) as an effective treatment to achieve long-term clinical benefits and to modify the natural history of allergic diseases. Sublingual immunotherapy\n (SLIT) offers the possibility of home administration, which improves patient comfort and compliance. Objective:<\/jats:bold> The primary outcome of this study was to assess the change in nasal reactivity after grass-pollen AIT treatment. Methods:<\/jats:bold> This was a monocentric,\n prospective, observational study conducted in Rome from September 2016 to June 2018, in the Pediatric Department of Policlinico Umberto I. We enrolled children, ages between 6 and 12 years, with persistent allergic rhinitis (AR), sensitized to grass pollen. At the first visit (V0, September\n 2016), one group received the first dose of oral immunotherapy for grass-pollen spray buccal and the other group continued only standard therapy. All the patients had nasal specific immunoglobulin I (IgE) assay (Phl p1, Phl p5), active anterior rhinomanometry with a nasal provocation test\n (NPT), and spirometry. The patients attended two follow-up visits, in May 2017 (V1) and May 2018 (V2), with the same examinations as at V0. Results:<\/jats:bold> During the treatment, we observed, in the treated group, a significant increase in the mean nasal flow compared with untreated\n children (p\u2009<\u20090.001). In the AIT group, we found an improvement of nasal function and only 21.05% of all the children in the active group with a positive NPT result at V2. In the control group, we found, at V2, a worsening of nasal function, with 89.47% of the children with\n a positive NPT result. Furthermore, we found a significant reduction of nasal specific IgE levels at the end of the observation period in the treated group. Conclusion:<\/jats:bold> Analysis of our data provided evidence for a clinical effect of SLIT in inducing clinical changes and\n allergen tolerance in children with AR.<\/jats:p>","DOI":"10.2500\/aap.2020.41.200063","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T04:33:55Z","timestamp":1598934835000},"page":"357-362","source":"Crossref","is-referenced-by-count":9,"title":["Nasal reactivity evaluation in children with allergic rhinitis receiving grass pollen sublingual immunotherapy"],"prefix":"10.2500","volume":"41","author":[{"given":"Laura","family":"Schiavi","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Sapienza University of Rome, Rome, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Brindisi","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Sapienza University of Rome, Rome, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"De Castro","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Sapienza University of Rome, Rome, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"De Vittori","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Sapienza University of Rome, Rome, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Loffredo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Spalice","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Sapienza University of Rome, Rome, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Duse","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Sapienza University of Rome, Rome, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Zicari","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Sapienza University of Rome, Rome, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2020\/00000041\/00000005\/art00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T04:47:39Z","timestamp":1600836459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2020.41.200063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9,1]]}},"alternative-id":["1088-5412(20200901)41:5L.357;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2020.41.200063","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}