{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:50:17Z","timestamp":1777639817884,"version":"3.51.4"},"reference-count":25,"publisher":"Oceanside Publications Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Food protein\u2010induced enterocolitis syndrome (FPIES) is a rare non-IgE mediated food allergy.  <jats:bold>Objective:<\/jats:bold> To delineate the differences in the spectrum of culprit foods, remission patterns, and predictors among varying cultures. \n <jats:bold>Methods:<\/jats:bold> We reviewed demographics, culprit foods, outcomes, and predictors in 81 children with a diagnosis of FPIES who were followed up between 2015 and 2020.  <jats:bold>Results:<\/jats:bold> Eighty-one patients (55.6% boys) were enrolled, including 72 with acute FPIES and 9 with chronic\n FPIES. Hen\u2019s egg was the most common culprit food (36.6%), followed by fish (26.9%), and cow\u2019s milk (21.5%). Interestingly, cow\u2019s milk was significantly prevalent in chronic FPIES cases (p\u2009=\u20090.006). The most common clinical symptoms were vomiting (100%), pallor\n (63.4%), and lethargy (55.9%). Emergency department visits were noted in 39 patients (41.9%), of whom 37 (39.8%) were treated with intravenous (IV) fluid. The subjects were followed up for a median (interquartile range) of 19.4 months (12.3\u201041.2 months), and 26 subjects (32.1%) achieved\n tolerance. The median (interquartile range) age at tolerance was 2.5 years (2.1\u20103.2 years). With regard to the culprit foods, hen\u2019s egg was observed more frequently in the subjects with resolved FPIES cases (p\u2009=\u20090.008), whereas fish FPIES cases were high in the persistent\n group (p\u2009=\u20090.001). IgE sensitization of the culprit food was found to be an independent risk factor for the persistence of FPIES (odds ratio 4.855 [95% confidence interval, 1.131\u201020.844]; p\u2009=\u20090.034).  <jats:bold>Conclusion:<\/jats:bold> In our cohort, unlike other\n published series, hen\u2019s egg and fish were the two most common culprit foods. Fish differed from other culprit foods, with significantly delayed onset and persistence, and may create a model that allows for the understanding of the disease.<\/jats:p>","DOI":"10.2500\/aap.2020.41.200078","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T05:00:37Z","timestamp":1603861237000},"page":"420-427","source":"Crossref","is-referenced-by-count":18,"title":["Phenotypes and natural history of food protein\u2010induced enterocolitis syndrome in the east Mediterranean region"],"prefix":"10.2500","volume":"41","author":[{"given":"Melike","family":"Ocak","sequence":"first","affiliation":[{"name":"From the Department of Pediatric Allergy, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015feg\u00fcl","family":"Akarsu","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Allergy, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit Murat","family":"Sahiner","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Allergy, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozge","family":"Soyer","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Allergy, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent Enis","family":"Sekerel","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Allergy, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.jaci.2019.06.032","article-title":"Food protein-induced enterocolitis syndrome in the US population-based study","volume":"144","author":"Nowak-Wegrzyn","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jaci.2010.12.1105","article-title":"The prevalence and natural course of food protein-induced enterocolitis syndrome to cow\u2019s milk: a large-scale, prospective population-based study","volume":"127","author":"Katz","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jaci.2017.03.027","article-title":"Food protein-induced enterocolitis syndrome in Australia: a population-based study, 2012-2014","volume":"140","author":"Mehr","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jaci.2018.08.045","article-title":"Food protein-induced enterocolitis syndrome: increased prevalence of this great unknown-results of the PREVALE study","volume":"143","author":"Alonso","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jaci.2016.12.966","article-title":"International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology","volume":"139","author":"Nowak-Wegrzyn","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2500\/aap.2015.36.3811","article-title":"Food protein-induced enterocolitis syndrome and allergic proctocolitis","volume":"36","author":"Nowak-Wegrzyn","year":"2015","journal-title":"Allergy Asthma Proc"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jaci.2020.01.001","article-title":"Food aversion and poor weight gain in food protein-induced enterocolitis syndrome: aretrospective study","volume":"145","author":"Su","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1365-2222.2012.04027.x","article-title":"A multicentre retrospective study of 66 Italian children with food protein-induced enterocolitis syndrome: different management for different phenotypes","volume":"42","author":"Sopo","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"B9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/MPG.0000000000002169","article-title":"Food protein-induced enterocolitis syndrome: data from a multicenter retrospective study in Spain","volume":"68","author":"Diaz","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B10","first-page":"731","article-title":"Food protein-induced enterocolitis syndrome caused by fish and\/or shellfish in Italy. 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