{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T14:05:39Z","timestamp":1744121139759},"reference-count":35,"publisher":"Oceanside Publications Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Several factors that increase the risk of severe food-induced anaphylaxis have been identified.<jats:bold>Objective:<\/jats:bold>We aimed to determine the demographic, etiologic, and clinical features of food-induced anaphylaxis in early childhood and also any other factors associated with severe anaphylaxis.<jats:bold>Methods:<\/jats:bold>We carried out a medical chart review of anaphylaxis cases from 16 pediatric allergy and immunology centers in Turkey.<jats:bold>Results:<\/jats:bold>The data of 227 patients with 266 food-induced anaphylaxis episodes were included in the study. The median (interquartile range) age of the first anaphylaxis episode was 9 months (6\u201018 months); 160 of these patients were boys (70.5%). The anaphylaxis episodes were mild in 75 cases (28.2%), moderate in 154 cases (57.9%), and severe in 37 cases (13.9%). The most frequent food allergens involved were cow's milk (47.4%), nuts (16.7%), and hen's egg (15.8%). Epinephrine was administered in only 98 (36.8%) of these anaphylaxis episodes. A logistic regression analysis revealed two statistically significant factors that were independently associated with severe anaphylaxis: the presence of angioedema and hoarseness during the anaphylactic episode. Urticaria was observed less frequently in patients who developed hypotension. In addition, confusion and syncope were associated with 25.9- and 44.6-fold increases, respectively, in the risk of concomitant hypotension.<jats:bold>Conclusion:<\/jats:bold>Cow's milk, nuts, and hen's egg caused the majority of mild and moderate-to-severe anaphylaxis episodes. The presence of angioedema and hoarseness in any patient who presents with a history of food-induced anaphylaxis should alert clinicians that the reaction may be severe. In addition, the presence of confusion, syncope, or stridor probably indicates concomitant hypotension.<\/jats:p>","DOI":"10.2500\/aap.2021.42.210051","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T16:52:36Z","timestamp":1630947156000},"page":"e135-e144","source":"Crossref","is-referenced-by-count":4,"title":["Food-induced anaphylaxis in early childhood and factors associated with its severity"],"prefix":"10.2500","volume":"42","author":[{"given":"Metin","family":"Aydogan","sequence":"first","affiliation":[{"name":"From the Pediatric Allergy and Immunology Department, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdem","family":"Topal","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Department, Faculty of Medicine, Inonu University, Malatya, 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