{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:55:52Z","timestamp":1792295752229,"version":"4.4.0"},"reference-count":38,"publisher":"Oceanside Publications Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Acute exacerbations of chronic rhinosinusitis (AECRS) are associated with significant morbidity and decreased quality of life. There are sparse data assessing the real-world impact of biologics on AECRS.  <jats:bold>Objectives:<\/jats:bold> We sought to determine the\n impact of type 2\u2010targeting biologics on the frequency of medication use for AECRS episodes.  <jats:bold>Methods:<\/jats:bold> Antibiotic and\/or systemic corticosteroid courses for AECRS were identified in a retrospective study from November 2015 to February 2020, at a single academic health\n system. The estimated yearly rates for antibiotic and corticosteroid courses were evaluated before and after initiation of type 2 biologics.  <jats:bold>Results:<\/jats:bold> One-hundred and sixty-five patients with chronic rhinosinusitis (CRS) had received either omalizumab (n = 12), mepolizumab\n (n = 42), benralizumab (n = 44), dupilumab (n = 61), or reslizumab (n = 6). Seventy percent had CRS with nasal polyps, and 30% had CRS without nasal polyps. All the patients had asthma. When all the biologics were combined, the estimated yearly rate for antibiotics for AECRS decreased from\n 1.34 (95% confidence interval [CI], 1.12\u20101.59) to 0.68 (95% CI, 0.52\u20100.88) with biologic use (49% reduction, <jats:italic>p<\/jats:italic> &lt; 0.001). Those with frequent AECRS (three or more courses of antibiotics in the 1 year before biologic use) had a larger degree of reduction, with an estimated\n yearly rate of 4.15 (95% CI, 3.79\u20104.55) to 1.58 (95% CI, 1.06\u20102.35) with biologic use (n = 27; 62% reduction; p &lt; 0.001). Within the total cohort, the estimated yearly rate for systemic corticosteroids for AECRS decreased from 1.69 (95% CI, 1.42\u20102.02) to 0.68 (95% CI,\n 0.53\u20100.88) with biologic use (60% reduction; p &lt; 0.001).  <jats:bold>Conclusion:<\/jats:bold> Type 2\u2010targeting biologics reduced medication use for AECRS. This suggested that biologics may be a therapeutic option for patients with frequent AECRS.<\/jats:p>","DOI":"10.2500\/aap.2021.42.210058","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T16:52:36Z","timestamp":1630947156000},"page":"417-424","source":"Crossref","is-referenced-by-count":18,"title":["Impact of type 2 targeting biologics on acute exacerbations of chronic rhinosinusitis"],"prefix":"10.2500","volume":"42","author":[{"given":"Gayatri B.","family":"Patel","sequence":"first","affiliation":[{"name":"From the Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Kudlaty","sequence":"additional","affiliation":[{"name":"From the Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, 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