{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:28:28Z","timestamp":1742387308704},"reference-count":113,"publisher":"Oceanside Publications Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated the worst global pandemic in a century, which has caused millions of infections and deaths as well as massive economic repercussions.  <jats:bold>Objective:<\/jats:bold> As\n with any pathogenic virus, it is crucial to understand its unique interactions with the human immune system so that pharmaceutical and prophylactic interventions can be deployed to effectively control the pandemic.  <jats:bold>Methods:<\/jats:bold> A literature search by using PubMed was conducted\n in 2020 with variants of the terms \u201cCOVID-19,\u201d \u201cSARS-CoV-2,\u201d and \u201cimmunological response.\u201d English language articles that presented original data about the immunologic response to coronavirus disease 2019 (COVID-19) were selected for review. This article\n reviewed the current understanding of the innate and adaptive immune responses to SARS-CoV-2 infection, including their relationship to current therapeutic and diagnostic strategies.  <jats:bold>Results:<\/jats:bold> SARS-CoV-2 uses several unique molecular techniques to evade detection by the\n innate immune system early in the course of infection, and upregulation of these innate immune pathways may possibly accelerate the time to recovery and prevent severe disease. Although the majority of cases results in the patients' recovery, a significant proportion of infections result in\n deaths prompted by the host's inflammatory overreaction to the infection, a response that can be attenuated with corticosteroids and potentially other immune modulators.  <jats:bold>Conclusion:<\/jats:bold> Current work by the scientific community to further understand how SARS-CoV-2 interacts\n with the human immune system will be invaluable to our response and preparedness for future coronavirus pandemics.<\/jats:p>","DOI":"10.2500\/aap.2021.42.210077","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T20:07:14Z","timestamp":1638821234000},"page":"495-505","source":"Crossref","is-referenced-by-count":5,"title":["The immunologic response to severe acute respiratory syndrome coronavirus 2"],"prefix":"10.2500","volume":"42","author":[{"given":"Nicole K.","family":"Le","sequence":"first","affiliation":[{"name":"From the Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Kaman","sequence":"additional","affiliation":[{"name":"Divison of Rheumatology, Allergy and Immunology, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah C.","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Immunology, Brigham and Women's Hospital, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotsna","family":"Mullur","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Immunology, Brigham and Women's Hospital, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen K.","family":"Stenehjem","sequence":"additional","affiliation":[{"name":"Division of Allergy and 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