{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:38:09Z","timestamp":1789799889847,"version":"4.0.1"},"reference-count":46,"publisher":"Oceanside Publications Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>There are conflicting data with regard to the impact of respiratory and allergic comorbidities on the course of novel coronavirus disease 2019 (COVID-19) in children.<jats:bold>Objective:<\/jats:bold>This study aimed to investigate the relationship between allergic diseases and COVID-19 severity in pediatric patients.<jats:bold>Methods:<\/jats:bold>Seventy-five pediatric patients with COVID-19 were classified according to clinical severity and evaluated in the allergy\/immunology and pulmonology departments 1 to 3 months after the infection resolved. Blood was collected from the patients for a complete blood cell count and assessment of immunoglobulin and total immunoglobulin E (IgE) levels, and skin-prick tests and spirometry tests were performed.<jats:bold>Results:<\/jats:bold>A total of 75 patients ages 5\u201018 years were evaluated. COVID-19 was asymptomatic\/mild in 44 patients and moderate\/severe\/critical in 31 patients. Based on allergy evaluation, allergic rhinitis was diagnosed in 19 patients (25.3%), asthma in 10 patients (13%), and atopic dermatitis in 3 patients (4%). Aeroallergen sensitivity was detected in 26 patients (34.7%). COVID-19 infection was asymptomatic\/mild in 15 patients with allergic rhinitis (78.9%) and in 21 with aeroallergen sensitivity (80.8%) (p = 0.038 and p = 0.005, respectively). There was no difference in severity between the patients with and without asthma (p = 0.550). The median (interquartile range) total IgE level was significantly higher in the asymptomatic\/mild group (71.8 [30.7\u2010211.2]) (p = 0.015). There were no differences in terms of spirometry parameters.<jats:bold>Conclusion:<\/jats:bold>Aeroallergen sensitization and allergic rhinitis in children may be associated with a milder course of COVID-19. The knowledge that atopy is associated with less-severe COVID-19 outcomes in children may guide clinical risk classification.<\/jats:p>","DOI":"10.2500\/aap.2021.42.210087","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T20:07:14Z","timestamp":1638821234000},"page":"522-529","source":"Crossref","is-referenced-by-count":28,"title":["Does aeroallergen sensitivity and allergic rhinitis in children cause milder COVID-19 infection?"],"prefix":"10.2500","volume":"42","author":[{"given":"Emine","family":"Vezir","sequence":"first","affiliation":[{"name":"From the Department of Pediatric Allergy and Clinical Immunology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Hizal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, 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