{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:46:58Z","timestamp":1761061618997},"reference-count":28,"publisher":"Oceanside Publications Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The clinical effects of intranasal corticosteroids (INC) on nasal symptoms and the clinical course of coronavirus disease 2019 (COVID-19) in subjects with chronic rhinitis (CR) seem unclear.  <jats:bold>Objective:<\/jats:bold> To evaluate the clinical effects of INCs\n on nasal symptoms in subjects with CR and with COVID-19.  <jats:bold>Methods:<\/jats:bold> In subjects with CR and diagnosed with COVID-19 at four tertiary centers, quality of life and nasal symptoms were assessed by using the 22-item Sino-Nasal Outcome Test (SNOT-22) and the visual analog scale\n (VAS), respectively. In subjects with allergic rhinitis, nasal symptoms were also assessed on the total symptom score-6 (TSS-6) scale. The subjects were then allocated into two groups according to whether or not they used INCs while infected with the severe acute respiratory syndrome coronavirus\n 2 (group 1 and group 2, respectively). The subjects in group 2 were divided into two subgroups according to the use of antihistamines and\/or leukotriene receptor antagonist or not (group 2a and group 2b, respectively). All the scores were compared before and during COVID-19 among the three\n groups.  <jats:bold>Results:<\/jats:bold> A total of 71 subjects (21 in group 1, 24 in group 2a, and 26 in group 2b) were enrolled. The total scores of the SNOT-22 increased remarkably in all the groups during the infection when compared with the pre\u2010COVID-19 scores (p &lt; 0.001 in each\n group). However, the difference between the pre\u2010COVID-19 and COVID-19 values revealed a lower decrease in the senses of smell and\/or taste in group 1 than in group 2a and group 2b (p = 0.015, adjusted p = 0.045; and p = 0.001, adjusted p = 0.002, respectively). There were no significant\n differences in other COVID-19 findings, VAS, and TSS-6 scores among the groups (all p &gt; 0.05).  <jats:bold>Conclusion:<\/jats:bold> INCs in subjects with CR seemed protective against the decrease in smell and\/or taste observed during COVID-19 and do not aggravate the clinical course of COVID-19.<\/jats:p>","DOI":"10.2500\/aap.2022.43.210116","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T10:47:26Z","timestamp":1648032446000},"page":"106-115","source":"Crossref","is-referenced-by-count":7,"title":["Clinical effects of intranasal corticosteroids on nasal symptoms in subjects with chronic rhinitis during COVID-19"],"prefix":"10.2500","volume":"43","author":[{"given":"Can","family":"Tuzer","sequence":"first","affiliation":[{"name":"From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelin","family":"Karadag","sequence":"additional","affiliation":[{"name":"From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozan","family":"Yegit","sequence":"additional","affiliation":[{"name":"From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Eyice","sequence":"additional","affiliation":[{"name":"From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nida","family":"Oztop","sequence":"additional","affiliation":[{"name":"From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Can","sequence":"additional","affiliation":[{"name":"From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra","family":"Demir","sequence":"additional","affiliation":[{"name":"From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raif","family":"Coskun","sequence":"additional","affiliation":[{"name":"Adult Immunology and Allergy Clinic, Okmeydan\u0131 Education and Research Hospital, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Erdogdu Unal","sequence":"additional","affiliation":[{"name":"Adult Immunology and Allergy Clinic, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey; 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