{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:18:42Z","timestamp":1770985122752,"version":"3.50.1"},"reference-count":30,"publisher":"Oceanside Publications Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cough is often the most prominent and intractable symptom reported by patients with asthma, but few studies have explored the characteristics of patients with asthma and with chronic cough (CC) in a real-world setting.  <jats:bold>Methods:<\/jats:bold> In a prospective\n cohort study, patients ages \u2265 18 years with stable asthma were consecutively recruited at the West China Hospital, Sichuan University. The patients were classified as having asthma with CC (the CC group) or asthma with non-CC (the non-CC group) after 3 months of optimized asthma therapy\n according to standard guidelines. Multidimensional assessment was performed at baseline, followed by a 12-month follow-up to assess asthma exacerbations.  <jats:bold>Results:<\/jats:bold> Of 323 patients with asthma, 127 patients were assigned to the CC group and 196 patients were assigned to the\n non-CC group. The participants with CC were older and had more airflow obstruction; worse asthma control and quality of life; increased airway inflammation; upper respiratory tract infection as a trigger; and more comorbidities, such as psychological dysfunction, rhinitis, chronic obstructive\n pulmonary disease, and bronchiectasis. They reported greater work productivity loss and daily activity impairment, and increased moderate-to-severe exacerbations.  <jats:bold>Conclusion:<\/jats:bold> The participants with asthma and with CC had a significant disease burden, with increased exacerbations,\n health-care utilization, and impaired work productivity and daily activity. These observations indicated potential clinical implications in patients with asthma and with CC, and call for more attention to this aspect of asthma.<\/jats:p>","DOI":"10.2500\/aap.2022.43.220022","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T04:32:07Z","timestamp":1651897927000},"page":"209-219","source":"Crossref","is-referenced-by-count":14,"title":["Chronic cough in asthma is associated with increased airway inflammation, more comorbidities, and worse clinical outcomes"],"prefix":"10.2500","volume":"43","author":[{"given":"Su Jun","family":"Deng","sequence":"first","affiliation":[{"name":"From the Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Gibson","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council Centre for Research Excellence in Severe Asthma and Treatable Traits, The University of Newcastle, Newcastle, New South Wales, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Respiratory Division of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, Shanghai, P.R. China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surinder S.","family":"Birring","sequence":"additional","affiliation":[{"name":"Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, P.R. China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke Fang","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne 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