{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:38:38Z","timestamp":1771472318062,"version":"3.50.1"},"reference-count":20,"publisher":"Oceanside Publications Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> This study aimed to evaluate the preliminary diagnosis, demographic characteristics, and outcomes of patients whose serum total tryptase levels were measured while in a tertiary pediatric hospital and to ascertain the role of serum tryptase levels in the etiology,\n diagnosis, severity, and course of systemic anaphylaxis.  <jats:bold>Methods:<\/jats:bold> Patients ages between 1 month and 17 years who were followed up in the pediatric emergency department or as inpatients and with a diagnosis of immediate-type reactions between September 1, 2019, and August\n 31, 2021, were included in the study. Patient data were obtained retrospectively by examination of medical records and patient observation forms.  <jats:bold>Results:<\/jats:bold> It was determined that serum tryptase levels were measured in a total of 310 patients during the study period. One\n hundred and fifty-five patients who met the defined diagnostic criteria were named as the anaphylaxis group and their data were detailed. The serum tryptase elevation was detected in 15.5% of the patients among the samples that met the anaphylaxis diagnostic criteria. No relationship was found\n between the serum total tryptase levels, the triggering factor, and the severity of anaphylaxis.  <jats:bold>Discussion:<\/jats:bold> Anaphylaxis is a complex syndrome that involves different phenotypes that develop with various triggers in which different immunologic pathways, cell types, and\n mediators play a role. Serial measurements, including the basal value measured at least 24 hours after the symptoms disappear, are useful to confirm the diagnosis and guide the diagnostic tests during the follow-up, especially allergy evaluation.<\/jats:p>","DOI":"10.2500\/aap.2022.43.220042","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T01:05:57Z","timestamp":1656723957000},"page":"e40-e46","source":"Crossref","is-referenced-by-count":4,"title":["Clinical utility of serum tryptase levels in pediatric anaphylaxis"],"prefix":"10.2500","volume":"43","author":[{"given":"Zeynep","family":"\u015eeng\u00fcl Emeksiz","sequence":"first","affiliation":[{"name":"From the University of Health Sciences, Ankara City Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"From the University of Health Sciences, Ankara City Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ba\u015fak","family":"Alan","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Ankara City Hospital, Department of Pediatrics, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Secil Doga","family":"Tunc","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Ankara City Hospital, Department of Pediatrics, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Dibek M\u0131s\u0131rl\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"From the University of Health Sciences, Ankara City Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/ACI.0000000000000184","article-title":"Biomarkers of anaphylaxis, beyond tryptase","volume":"15","author":"Sala-Cunill","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.iac.2006.05.010","article-title":"Diagnostic value of tryptase in anaphylaxis and mastocytosis","volume":"26","author":"Schwartz","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"key":"B3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000506199","article-title":"Elevated serum tryptase in non-anaphylaxis cases: a concise review","volume":"181","author":"Lee","year":"2020","journal-title":"Int Arch Allergy Immunol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/ACI.0000000000000569","article-title":"Tryptase values in anaphylaxis and insect allergy","volume":"19","author":"Bonadonna","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/all.12437","article-title":"Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology","volume":"69","author":"Muraro","year":"2014","journal-title":"Allergy"},{"key":"B6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jaci.2004.04.029","article-title":"Clinical features and severity grading of anaphylaxis","volume":"114","author":"Brown","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"B7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000339749","article-title":"Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis in 102 patients","volume":"160","author":"Sala-Cunill","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/ACI.0000000000000472","article-title":"Phenotypes, endotypes and biomarkers in anaphylaxis: current insights","volume":"18","author":"Sala-Cunill","year":"2018","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"B9","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2340\/00015555-1245","article-title":"Impact of age and heterophilic interference on the basal serum tryptase, a risk indication for anaphylaxis, in 1,092 dermatology patients","volume":"92","author":"Schliemann","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"B10","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.jaci.2015.09.001","article-title":"Tryptase levels in children presenting with anaphylaxis: temporal trends and associated factors","volume":"137","author":"De Schryver","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B11","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.jaip.2017.06.021","article-title":"Anaphylaxis and clinical utility of real-world measurement of acute serum tryptase in UK emergency departments","volume":"5","author":"Buka","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B12","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jaip.2019.07.015","article-title":"Postmortem tryptase cutoff points and main causes of fatal anaphylaxis","volume":"8","author":"Tejedor-Alonso","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B13","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.jaip.2018.01.006","article-title":"Diagnostic value of tryptase in food allergic reactions: a prospective study of 160 adult peanut challenges","volume":"6","author":"Dua","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000497235","article-title":"Serum baseline tryptase level as a marker for the severity of anaphylaxis","volume":"179","author":"Aniceto","year":"2019","journal-title":"Int Arch Allergy Immunol"},{"key":"B15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.23822\/EurAnnACI.1764-1489.133","article-title":"Recommendations for the use of tryptase in the diagnosis of anaphylaxis and clonal mastcell disorders","volume":"52","author":"Platzgummer","year":"2020","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"B16","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12016-020-08777-7","article-title":"Using baseline and peak serum tryptase levels to diagnose anaphylaxis: a review","volume":"58","author":"Passia","year":"2020","journal-title":"Clin Rev Allergy Immunol"},{"key":"B17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/ACI.0b013e32833d12fd","article-title":"Elevated baseline mast cell tryptase: a marker of severe insect venom anaphylaxis","volume":"10","author":"Heine","year":"2010","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"B18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/all.12317","article-title":"Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy","volume":"69","author":"Sahiner","year":"2014","journal-title":"Allergy"},{"key":"B19","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.jaip.2020.05.057","article-title":"Hereditary alpha-tryptasemia: UK prevalence and variability in disease expression","volume":"8","author":"Robey","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.anai.2021.01.016","article-title":"Hereditary alpha-tryptasemia in 101 patients with mast cell activation-related symptomatology including anaphylaxis","volume":"126","author":"Giannetti","year":"2021","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2022\/00000043\/00000005\/art00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:36:27Z","timestamp":1742358987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2022.43.220042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["1088-5412(20220901)43:5L.40;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2022.43.220042","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}