{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:34:30Z","timestamp":1781642070716,"version":"3.54.5"},"reference-count":34,"publisher":"Oceanside Publications Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Limited data exist on the clinical and economic burden of chronic rhinosinusitis with nasal polyposis (CRSwNP).  <jats:bold>Objective:<\/jats:bold> To describe patient characteristics, health-care resource utilization (HCRU), and health-care costs among patients with\n CRSwNP with and without comorbid asthma (primary analysis) and with surgical management of nasal polyps (secondary analysis).  <jats:bold>Methods:<\/jats:bold> This was a retrospective study of patients diagnosed with CRSwNP conducted using administrative claims data from January 1, 2013, through\n March 31, 2019. Study outcomes were assessed over a 2-year follow-up. Results were stratified by baseline asthma status (primary analysis) and presented separately for patients with surgically managed CRSwNP (secondary analysis).  <jats:bold>Results:<\/jats:bold> The primary analysis included 10,999\n patients with CRSwNP (2649 with asthma, 8350 without asthma). Patients with versus without asthma had higher medication use, HCRU, and all-cause medical costs (mean \u00b1 standard deviation $34,667 \u00b1 $42,234 versus $27,122 \u00b1 $45,573; p &lt; 0.001)\n across the full follow-up period. CRSwNP-related medical costs were significantly higher for patients with versus without asthma in year 2 of follow-up. In the surgical management analysis (n = 4943), most categories of medication use and CRSwNP-related HCRU declined from baseline levels during\n follow-up, and CRSwNP-related pharmacy costs in year 2 were less than half of baseline levels.  <jats:bold>Conclusion:<\/jats:bold> Patients diagnosed with CRSwNP and asthma had a greater burden of illness than those without asthma. Higher CRSwNP-related medical costs in year 2 of follow-up for\n patients with asthma may indicate worsening symptoms over time. Among patients with surgically managed CRSwNP, HCRU and costs increased in year 1 of follow-up but decreased below baseline levels in year 2, potentially reflecting improved symptom severity.<\/jats:p>","DOI":"10.2500\/aap.2022.43.220048","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T04:31:22Z","timestamp":1662438682000},"page":"435-445","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and economic burden of chronic rhinosinusitis with nasal polyposis: A U.S. administrative claims analysis"],"prefix":"10.2500","volume":"43","author":[{"given":"Anju T.","family":"Peters","sequence":"first","affiliation":[{"name":"From the Division of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay G.S.","family":"Bengtson","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research, Optum Life Sciences, Eden Prairie, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen","family":"Chung","sequence":"additional","affiliation":[{"name":"BioPharmaceuticals Medical, AstraZeneca, Wilmington, Delaware;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit K.","family":"Katial","sequence":"additional","affiliation":[{"name":"BioPharmaceuticals Medical, AstraZeneca, Wilmington, Delaware;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Kreindler","sequence":"additional","affiliation":[{"name":"BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cori J.","family":"Blauer-Peterson","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research, Optum Life Sciences, Eden Prairie, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Proliance Surgeons, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMcp1800215","article-title":"Chronic rhinosinusitis with nasal polyps","volume":"381","author":"Hopkins","year":"2019","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2500\/ajra.2013.27.3981","article-title":"Epidemiology and differential diagnosis of nasal polyps","volume":"27","author":"Chaaban","year":"2013","journal-title":"Am J Rhinol Allergy"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jaip.2018.10.014","article-title":"Clinical characteristics of patients with chronic rhinosinusitis without nasal polyps in an academic setting","volume":"7","author":"Benjamin","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B4","doi-asserted-by":"crossref","first-page":"O1","DOI":"10.1186\/2045-7022-5-S4-O1","article-title":"The GA(2)LEN sinusitis cohort: an introduction","volume":"5","author":"Vandeplas","year":"2015","journal-title":"Clin Transl Allergy"},{"key":"B5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2500\/aap.2019.40.4182","article-title":"A cross-sectional, population-based survey of U.S. adults with symptoms of chronic rhinosinusitis","volume":"40","author":"Palmer","year":"2019","journal-title":"Allergy Asthma Proc"},{"key":"B6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/13696998.2018.1452748","article-title":"Disease-related expenditures and revision rates in chronic rhinosinusitis patients after endoscopic sinus surgery","volume":"21","author":"Hunter","year":"2018","journal-title":"J Med Econ"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/lary.27852","article-title":"Cost burden and resource utilization in patients with chronic rhinosinusitis and nasal polyps","volume":"129","author":"Bhattacharyya","year":"2019","journal-title":"Laryngoscope"},{"key":"B8","doi-asserted-by":"crossref","first-page":"2473974X20950727","DOI":"10.1177\/2473974X20950727","article-title":"Burden of nasal polyps in the United States","volume":"4","author":"Ference","year":"2020","journal-title":"OTO Open"},{"key":"B9","first-page":"343","article-title":"The GALEN rhinosinusitis cohort: chronic rhinosinusitis with nasal polyps affects health-related quality of life","volume":"57","author":"Khan","year":"2019","journal-title":"Rhinology"},{"key":"B10","first-page":"45","article-title":"Nasal polyps in patients with asthma: prevalence, impact, and management challenges","volume":"9","author":"Langdon","year":"2016","journal-title":"J Asthma Allergy"},{"key":"B11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.anai.2014.07.025","article-title":"Diagnosis and management of rhinosinusitis: a practice parameter update","volume":"113","author":"Peters","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B12","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00405-020-06334-8","article-title":"Endoscopic sinus surgery outcomes in CRS: quality of life and correlations with NOSE scale in a prospective cohort study","volume":"278","author":"Saratziotis","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00005537-200405000-00004","article-title":"Recurrence rates after endoscopic sinus surgery for massive sinus polyposis","volume":"114","author":"Wynn","year":"2004","journal-title":"Laryngoscope"},{"key":"B14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/all.12983","article-title":"Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre","volume":"72","author":"van der Veen","year":"2017","journal-title":"Allergy"},{"key":"B15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2500\/ajra.2016.30.4297","article-title":"Chronic rhinosinusitis: epidemiology and burden of disease","volume":"30","author":"DeConde","year":"2016","journal-title":"Am J Rhinol Allergy"},{"key":"B16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2500\/ajra.2017.31.4402","article-title":"Endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps: clinical outcome and predictive factors of recurrence","volume":"31","author":"Veloso-Teles","year":"2017","journal-title":"Am J Rhinol Allergy"},{"key":"B17","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/lary.24401","article-title":"Complications of primary and revision functional endoscopic sinus surgery for chronic rhinosinusitis","volume":"124","author":"Krings","year":"2014","journal-title":"Laryngoscope"},{"key":"B18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2500\/ajra.2012.26.3711","article-title":"Risk factors for complications of endoscopic sinus surgery for chronic rhinosinusitis","volume":"26","author":"Asaka","year":"2012","journal-title":"Am J Rhinol Allergy"},{"key":"B19","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/lary.25180","article-title":"Cost of adult chronic rhinosinusitis: a systematic review","volume":"125","author":"Smith","year":"2015","journal-title":"Laryngoscope"},{"key":"B20","article-title":"Consumer Price Index","journal-title":"Medical Care"},{"key":"B21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11882-017-0690-5","article-title":"Economics of chronic rhinosinusitis","volume":"17","author":"Rudmik","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"B22","doi-asserted-by":"crossref","first-page":"e0127228","DOI":"10.1371\/journal.pone.0127228","article-title":"Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported","volume":"10","author":"Hakansson","year":"2015","journal-title":"PLoS One"},{"key":"B23","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jaip.2020.09.063","article-title":"Chronic rhinosinusitis with nasal polyps and asthma","volume":"9","author":"Laidlaw","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13601-020-00332-z","article-title":"Distinct type 2-high inflammation associated molecular signatures of chronic rhinosinusitis with nasal polyps with comorbid asthma","volume":"10","author":"Wang","year":"2020","journal-title":"Clin Transl Allergy"},{"key":"B25","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jaip.2016.12.027","article-title":"Clinical characteristics of patients with chronic rhinosinusitis with nasal polyps, asthma, and aspirin-exacerbated respiratory disease","volume":"5","author":"Stevens","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B26","first-page":"151","article-title":"State-of-the-art overview on biological treatment for CRSwNP","volume":"59","author":"Hellings","year":"2021","journal-title":"Rhinology"},{"key":"B27","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/all.13875","article-title":"EUFOREA consensus on biologics for CRSwNP with or without asthma","volume":"74","author":"Fokkens","year":"2019","journal-title":"Allergy"},{"key":"B28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/alr.22487","article-title":"Revision surgery rates in chronic rhinosinusitis with nasal polyps: meta-analysis of risk factors","volume":"10","author":"Loftus","year":"2020","journal-title":"Int Forum Allergy Rhinol"},{"key":"B29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/alr.22505","article-title":"Factors impacting revision surgery in patients with chronic rhinosinusitis with nasal polyposis","volume":"10","author":"Loftus","year":"2020","journal-title":"Int Forum Allergy Rhinol"},{"key":"B30","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/0194599818773065","article-title":"Systematic review and meta-analysis of SNOT-22 outcomes after surgery for chronic rhinosinusitis with nasal polyposis","volume":"159","author":"Le","year":"2018","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B31","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.2500\/ajra.2016.30.4279","article-title":"Evaluation of residual symptoms: a method to assess surgical outcomes for nasal polyposis","volume":"30","author":"Nguyen","year":"2016","journal-title":"Am J Rhinol Allergy"},{"key":"B32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/lary.26391","article-title":"Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis","volume":"127","author":"DeConde","year":"2017","journal-title":"Laryngoscope"},{"key":"B33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4193\/Rhin17.255","article-title":"The Global Allergy and Asthma European Network (GALEN rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps","volume":"57","author":"Khan","year":"2019","journal-title":"Rhinology"},{"key":"B34","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/0145561320964653","article-title":"The role of biologics in chronic rhinosinusitis with nasal polyps","volume":"100","author":"Patel","year":"2021","journal-title":"Ear Nose Throat J"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2022\/00000043\/00000005\/art00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:34:34Z","timestamp":1742358874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2022.43.220048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["1088-5412(20220901)43:5L.435;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2022.43.220048","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}