{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:00:16Z","timestamp":1773270016572,"version":"3.50.1"},"reference-count":9,"publisher":"Oceanside Publications Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"Background:<\/jats:bold> 2-Octyl cyanoacrylate, a topical adhesive used for wound closure, is becoming a common cause for rashes in postsurgical patients. There is an increased number of cases of postsurgical contact dermatitis attributable to 2-octyl cyanoacrylate. Localized skin reactions\n to 2-octyl cyanoacrylate have been described in different case reports, but there are limited case reports of diffuse cutaneous allergic reactions. Objective:<\/jats:bold> The aim of the study was to review our experience in patch testing with cyanoacrylates. Methods:<\/jats:bold>\n We reported five cases of allergic contact dermatitis to 2-octyl cyanoacrylate, confirmed by a patch test. All the patients experienced a skin reaction a few days after surgery. The patients described an erythematous pruritic rash initially localized over the incision and that subsequently\n spread to surrounding areas. Two of the five patients developed a more widespread rash, which required a longer duration of systemic steroids. 2-Octyl cyanoacrylate remains an agent of low diagnostic suspicion as the possible cause of contact dermatitis after a surgical procedure. \n Results:<\/jats:bold> All the patients, but one had a positive reaction to 2-octyl cyanoacrylate on PT. Four had a positive PT result, with one patient having a positive scratch test after a negative PT result. Testing on abraded skin further increased yield. Conclusion:<\/jats:bold> Postsurgical\n patients should be evaluated by using a patch test if there is a clinical picture suggestive of contact dermatitis.<\/jats:p>","DOI":"10.2500\/aap.2022.43.220070","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T04:30:51Z","timestamp":1667709051000},"page":"529-532","source":"Crossref","is-referenced-by-count":10,"title":["2-Octyl cyanoacrylate, a hidden allergen, a common cause of postsurgical allergic contact dermatitis"],"prefix":"10.2500","volume":"43","author":[{"given":"Peggy E.","family":"Salazar","sequence":"first","affiliation":[{"name":"From the Division of Allergy and Immunology, Department of Medicine, Albany Medical College, Albany, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazia","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad A.","family":"Pasha","sequence":"additional","affiliation":[{"name":"From the Division of Allergy and Immunology, Department of Medicine, Albany Medical College, Albany, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1016\/j.arth.2021.04.033","article-title":"2-Octyl cyanoacrylate topical adhesive as an alternative to subcuticular suture for skin closure after total knee arthroplasty: a randomized controlled trial in the same patient","volume":"36","author":"Choi","year":"2021","journal-title":"J Arthroplasty"},{"key":"B2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/cod.12727","article-title":"Utility of scratch tests for allergic contact dermatitis caused by Dermabond\u00ae","volume":"76","author":"Lef\u00e8vre","year":"2017","journal-title":"Contact Dermatitis"},{"key":"B3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/DER.0000000000000163","article-title":"Severe allergic contact dermatitis to Dermabond Prineo, a topical skin adhesive of 2-octyl cyanoacrylate increasingly used in surgeries to close wounds","volume":"27","author":"Davis","year":"2016","journal-title":"Dermatitis"},{"key":"B4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/ajd.12843","article-title":"Contact dermatitis to Dermabond Advance\u00ae","volume":"60","author":"Kanazawa","year":"2019","journal-title":"Australas J Dermatol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaip.2015.02.009","article-title":"Contact dermatitis: a practice parameter\u2013update 2015","volume":"3","author":"Fonacier","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1017\/S1049023X14001010","article-title":"Diffuse cutaneous allergic reaction to Dermabond","volume":"29","author":"Ricci","year":"2014","journal-title":"Prehosp Disaster Med"},{"key":"B7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/cod.12597","article-title":"Allergic contact dermatitis caused by Dermabond (\u00ae)","volume":"75","author":"Lef\u00e8vre","year":"2016","journal-title":"Contact Dermatitis"},{"key":"B8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/DER.0000000000000514","article-title":"Patch testing ingredients of Dermabond and other cyanoacrylate-containing adhesives","volume":"30","author":"Cook","year":"2019","journal-title":"Dermatitis"},{"key":"B9","doi-asserted-by":"crossref","first-page":"e1841","DOI":"10.1097\/GOX.0000000000001841","article-title":"Contact dermatitis caused by Dermabond advanced use","volume":"6","author":"Nakagawa","year":"2018","journal-title":"Plastic Reconstr Surg Glob Open"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2022\/00000043\/00000006\/art00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T16:40:21Z","timestamp":1675183221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2022.43.220070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11,1]]}},"alternative-id":["1088-5412(20221101)43:6L.529;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2022.43.220070","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,1]]}}}