{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:23:51Z","timestamp":1792790631877,"version":"4.5.0"},"reference-count":18,"publisher":"Oceanside Publications Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare autoimmune disease that can affect multiple organ systems in the body. A majority of patients with EGPA present with asthma-like symptoms and may be misdiagnosed with refractory asthma. It is necessary\n to distinguish EGPA from asthma and provide a theoretical basis for effective future prevention and treatment.  <jats:bold>Objective:<\/jats:bold> This study aimed to compare the clinical features of EGPA and the clinical features of allergic asthma in an effort to make an early diagnosis possible.\n  <jats:bold>Methods:<\/jats:bold> We reviewed the basic information, test results, pre-onset conditions, and prognosis of 44 adult patients with EGPA who were admitted to our hospital between January 2013 and June 2021, and conducted a 1:1 matched case-control study to compare patients with EGPA and\n patients with allergic asthma.  <jats:bold>Results:<\/jats:bold> The 44 patients with EGPA were older than those with allergic asthma, but more than half of the patients with EGPA had been diagnosed with bronchial asthma, with a history of 10 months to 40 years, and had previously used inhalers\n or systemic steroids. The proportion of male-to-female cases was \u223c1:1, with seven antineutrophil cytoplasmic antibodies (ANCA) positive cases (15.9%), 20 limited EGPA cases (45.45%), and 24 systemic EGPA cases (54.55%). Although the peripheral blood eosinophil count and percentage were\n lower in the male patients than in the female patients, male patients with higher five-factor scores might indicate worse prognosis. The fractional exhaled nitric oxide (FeNO) level, eosinophil percentage and count, and total immunoglobulin E (IgE) level were higher in the EGPA group than\n in the allergic asthma group. Unlike in allergic asthma, the FeNO level is not correlated with the blood eosinophil count or percentage in EGPA. Seven patients received cardiac emission computed tomography (ECT) tests, with abnormalities suggested in six patients. Results of an electrocardiogram,\n color-Doppler echocardiography, myocardial enzyme level, and troponin level suggested no obvious abnormality.  <jats:bold>Conclusion:<\/jats:bold> The proportion of patients with EGPA who tested positive for ANCA is not high, and patients with high eosinophil counts should be alert to the possibility\n of having EGPA. For patients with infiltration of eosinophils into the airway, a diagnosis should not be based on peripheral blood eosinophil counts. It is recommended that the FeNO level and pulmonary function should also be monitored for patients who present with symptoms in other body systems.\n The sensitivity of cardiac ECT tests is higher than routine tests, so timely screening by cardiac ECT is recommended for all patients with EGPA.<\/jats:p>","DOI":"10.2500\/aap.2023.44.220072","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T04:46:31Z","timestamp":1672202791000},"page":"59-63","source":"Crossref","is-referenced-by-count":14,"title":["Eosinophilic granulomatosis with polyangiitis in allergic asthma: Efforts to make early diagnosis possible"],"prefix":"10.2500","volume":"44","author":[{"given":"Bo","family":"Zhao","sequence":"first","affiliation":[{"name":"From the Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Zheng","sequence":"additional","affiliation":[{"name":"From the Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Health Management, Shengjing Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zheng","sequence":"additional","affiliation":[{"name":"From the Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.alit.2019.06.004","article-title":"Update on eosinophilic granulomatosis with polyangiitis","volume":"68","author":"Furuta","year":"2019","journal-title":"Allergol Int"},{"key":"B2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/art.20077","article-title":"Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener's granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate","volume":"51","author":"Mahr","year":"2004","journal-title":"Arthritis Rheum"},{"key":"B3","first-page":"S1","article-title":"State of world allergy report 2008 allergy and chronic respiratory diseases","volume":"1","author":"Pawankar","year":"2008","journal-title":"World Allergy Organ J"},{"key":"B4","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/art.1780330806","article-title":"The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis)","volume":"33","author":"Masi","year":"1990","journal-title":"Arthritis Rheum"},{"key":"B5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MD.0b013e318205a4c6","article-title":"The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort","volume":"90","author":"Guillevin","year":"2011","journal-title":"Medicine (Baltimore)"},{"key":"B6","first-page":"514","article-title":"Expert consensus on diagnosis and treatment of eosinophilic granulomatous polyvasculitis","volume":"41","author":"Zhang","year":"2018","journal-title":"Chinese J Tuberculosis Respir Dis"},{"key":"B7","article-title":"GINA: Interim guidance about COVID-19 and asthma, updated 20 Dec 2020","journal-title":"The Global Initiative for Asthma"},{"key":"B8","first-page":"636","article-title":"Chinese guidelines for the diagnosis and treatment of allergic asthma (2019, the first edition)","volume":"58","year":"2019","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"B9","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","article-title":"An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications","volume":"184","author":"Dweik","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"B10","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/acr.22686","article-title":"Long-term followup of a multicenter cohort of 101 patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss)","volume":"68","author":"Durel","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B11","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1093\/rheumatology\/keaa805","article-title":"Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)","volume":"60","author":"Papo","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"B12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/art.37721","article-title":"Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort","volume":"65","author":"Comarmond","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S2213-2600(15)00050-8","article-title":"Diagnostic accuracy of minimally invasive markers for detection of airway eosinophilia in asthma: a systematic review and meta-analysis","volume":"3","author":"Korevaar","year":"2015","journal-title":"Lancet Respir Med"},{"key":"B14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2500\/aap.2021.42.210016","article-title":"Evaluation of the peripheral blood eosinophil count as a predictor for fractional exhaled nitric oxide or bronchodilator reversibility test outcome","volume":"42","author":"Zhao","year":"2021","journal-title":"Allergy Asthma Proc"},{"key":"B15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1398-9995.2008.01854.x","article-title":"Persistent airflow obstruction in asthma of patients with Churg-Strauss syndrome and long-term follow-up","volume":"64","author":"Cottin","year":"2009","journal-title":"Allergy"},{"key":"B16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaip.2015.12.014","article-title":"Asthma control and airway inflammation in patients with eosinophilic granulomatosis with polyangiitis","volume":"4","author":"Latorre","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B17","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1093\/rheumatology\/keab027","article-title":"Heart disease in eosinophilic granulomatosis with polyangiitis (EGPA) patients: a screening approach proposal","volume":"60","author":"Garcia-Vives","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"B18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s11739-021-02863-0","article-title":"The clinical features and treatment of eosinophilic granulomatosis with polyangiitis (EGPA) in Turkey: one or two distinct diseases?","volume":"17","author":"Duran","year":"2022","journal-title":"Intern Emerg Med"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2023\/00000044\/00000001\/art00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T16:42:45Z","timestamp":1675183365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2023.44.220072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"alternative-id":["1088-5412(20230101)44:1L.59;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2023.44.220072","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,1]]}}}