{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T18:01:59Z","timestamp":1706637719937},"reference-count":15,"publisher":"Oceanside Publications Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"Background:<\/jats:bold> Aspirin exacerbated respiratory disease (AERD) is an inflammatory condition that consists of eosinophilic asthma, chronic rhinosinusitis with nasal polyps, and respiratory reactions to cyclooxygenase-1 inhibitors. Aspirin therapy after aspirin desensitization\n (ATAD) is the most extensively studied treatment paradigm for AERD. Objective:<\/jats:bold> The objective was to identify which time point of ATAD was most predictive of long-term outcomes as measured by the 22-item Sino-Nasal Outcome Test (SNOT-22). Methods:<\/jats:bold> A retrospective\n chart review was conducted of patients at a single institution who underwent endoscopic sinus surgery, followed by ATAD, and had remained on ATAD for 2 consecutive years. SNOT-22 scores were recorded at predesensitization as well as at the 3-, 6-, 12-, and 24-month postdesensitization time\n points. The patients were separated into two cohorts at each of the data collection time points based on whether their SNOT-22 scores were < 20 (responders) or \u2265 20 (nonresponders). Responder status was compared between each time point and at 24-month postdesensitization. The odds ratios\n (OR) were then calculated between the two groups at each of the following time points: postsurgery\/predesensitization, and 3-, 6-, and 12-month postdesensitization. Results:<\/jats:bold> There were 70 patients who met the inclusion criteria of having 24-month postdesensitization SNOT-22\n scores available. Responder status at 6 months after surgery had the most predictive OR 16.5 (95% confidence interval, 3.71\u201073.44) for long-term outcomes at 24 months. Conclusion:<\/jats:bold> The SNOT-22 scores after 6 months of ATAD showed the greatest predictive value for\n long-term quality-of-life outcomes and, therefore, poor 6-month SNOT-22 scores could serve as a basis for consideration of alternative therapies.<\/jats:p>","DOI":"10.2500\/aap.2023.44.220091","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T04:46:31Z","timestamp":1672202791000},"page":"78-80","source":"Crossref","is-referenced-by-count":2,"title":["SNOT-22 scores after 6 months of aspirin therapy are predictive of long-term quality of life in AERD"],"prefix":"10.2500","volume":"44","author":[{"given":"Siddhant H.","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Corr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Ungerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John V.","family":"Bosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1056\/NEJMra1712125","article-title":"Aspirin-exacerbated respiratory disease","volume":"379","author":"White","year":"2018","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-030-50330-7_7","article-title":"Aspirin-exacerbated respiratory disease","volume-title":"The Unified Airway","author":"Sweis","year":"2020"},{"key":"B3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2500\/aap.2021.42.210002","article-title":"Effectiveness of endoscopic sinus surgery and aspirin therapy in the management of aspirin-exacerbated respiratory disease","volume":"42","author":"Sweis","year":"2021","journal-title":"Allergy Asthma Proc"},{"key":"B4","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.jaip.2021.01.032","article-title":"Multidisciplinary single-center outcomes compared to two-center outcomes for the treatment of aspirin exacerbated respiratory disease","volume":"9","author":"Bosso","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/alr.22604","article-title":"Complete endoscopic sinus surgery followed by aspirin desensitization is associated with decreased overall corticosteroid use","volume":"10","author":"Bosso","year":"2020","journal-title":"Int Forum Allergy Rhinol"},{"key":"B6","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/alr.22168","article-title":"Alcohol-induced respiratory symptoms improve after aspirin desensitization in patients with aspirin-exacerbated respiratory disease","volume":"8","author":"Glicksman","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"B7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.wjorl.2020.07.006","article-title":"Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores","volume":"6","author":"Naples","year":"2020","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"B8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/alr.22036","article-title":"Outcomes after complete endoscopic sinus surgery and aspirin desensitization in aspirin-exacerbated respiratory disease","volume":"8","author":"Adappa","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"B9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/1945892418770260","article-title":"Long-term clinical outcomes of aspirin desensitization with continuous daily aspirin therapy in aspirin-exacerbated respiratory disease","volume":"32","author":"Walters","year":"2018","journal-title":"Am J Rhinol Allergy"},{"key":"B10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.anai.2010.05.020","article-title":"Use of intranasal ketorolac and modified oral aspirin challenge for desensitization of aspirin-exacerbated respiratory disease","volume":"105","author":"Lee","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4193\/Rhino15.072","article-title":"Stratification of SNOT-22 scores into mild, moderate or severe and relationship with other subjective instruments","volume":"54","author":"Toma","year":"2016","journal-title":"Rhinology"},{"key":"B12","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/alr.22028","article-title":"Investigating the minimal clinically important difference for SNOT-22 symptom domains in surgically managed chronic rhinosinusitis","volume":"7","author":"Chowdhury","year":"2017","journal-title":"Int Forum Allergy Rhinol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"103025","DOI":"10.1016\/j.amjoto.2021.103025","article-title":"Pre-intervention SNOT-22 scores predict outcomes in aspirin exacerbated respiratory disease","volume":"42","author":"Kuan","year":"2021","journal-title":"Am J Otolaryngol"},{"key":"B14","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/cea.13886","article-title":"Biomarkers for predicting response to aspirin therapy in aspirin-exacerbated respiratory disease","volume":"51","author":"Tyrak","year":"2021","journal-title":"Clin Exp Allergy"},{"key":"B15","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/alr.22933","article-title":"Comparison of aspirin desensitization outcomes between men and women with AERD","volume":"12","author":"Tripathi","year":"2022","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2023\/00000044\/00000001\/art00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T16:42:32Z","timestamp":1675183352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2023.44.220091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"alternative-id":["1088-5412(20230101)44:1L.78;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2023.44.220091","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,1]]}}}