{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:20:12Z","timestamp":1770420012096,"version":"3.49.0"},"reference-count":27,"publisher":"Oceanside Publications Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Aspirin treatment after desensitization (ATAD) is effective in preventing nasal polyps recurrence as well as respiratory symptoms in patients with nonsteroidal anti-inflammatory drug (NSAID)\u2010exacerbated respiratory diseases (N-ERD). However, there is no\n consensus on effective daily maintenance doses in ATAD. Therefore, we aimed to compare the effects of two different maintenance doses of aspirin on clinical outcomes for 1\u20103 years of ATAD.  <jats:bold>Methods:<\/jats:bold> This was a retrospective, multicenter study that involved four tertiary\n centers. The maintenance doses of daily aspirin were 300 mg in one center and 600 mg in the remaining three. The data of patients who were on ATAD for 1\u20103 years were included. Study outcomes (nasal surgeries, sinusitis, asthma attacks, hospitalization, oral corticosteroid use, and medication\n uses) were assessed in a standardized way and recorded from case files.  <jats:bold>Results:<\/jats:bold> The study initially included 125 subjects, 38 and 87 were receiving 300 and 600 mg daily aspirin for ATAD, respectively. Number of nasal polyp surgeries decreased after 1 -3 years compared\n with before ATAD in both groups (group 1, baseline: 0.44 \u00b1 0.07 versus first year: 0.08 \u00b1 0.05; p &lt; 0.001 and baseline: 0.44 \u00b1 0.07 versus 3rd year: 0.01 \u00b1 0.01; p &lt; 0.001; and group 2, baseline 0.42 \u00b1 0.03 versus first year: 0.02 \u00b1 0.02; p &lt;\n 0.001 and baseline: 0.42 \u00b1 0.03 versus 3rd year: 0.07 \u00b1 0.03; p &lt; 0.001).  <jats:bold>Conclusion:<\/jats:bold> Given the comparable effects of 300 mg and 600 mg aspirin daily as maintenance treatment of ATAD on both asthma and sinonasal outcomes in N-ERD, our results suggest using\n 300 mg of aspirin daily in ATAD owing to its better safety profile.<\/jats:p>","DOI":"10.2500\/aap.2023.44.220103","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T04:30:44Z","timestamp":1678077044000},"page":"106-114","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of 300 mg versus 600 mg daily maintenance doses of aspirin treatment after desensitization in N-ERD: A three-year multicentre experience"],"prefix":"10.2500","volume":"44","author":[{"given":"Gulfem Elif","family":"Celik","sequence":"first","affiliation":[{"name":"From the Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gul","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Chest Diseases, Hacettepe University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferda Oner","family":"Erkekol","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adile Berna","family":"Dursun","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Recep Tayyip Erdo\u011fan University School of Medicine, Rize, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Gelincik","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omur","family":"Aydin","sequence":"additional","affiliation":[{"name":"From the Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Damadoglu","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Chest Diseases, Hacettepe University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taskin","family":"Yucel","sequence":"additional","affiliation":[{"name":"Department of Ear Nose and Throat, Hacettepe University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Yorulmaz","sequence":"additional","affiliation":[{"name":"Department of Ear Nose and Throat, Ankara University School of Medicine, Ankara, Turkey, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engin","family":"Dursun","sequence":"additional","affiliation":[{"name":"Department of Ear Nose and Throat, Recep Tayyip Erdo\u011fan University School of Medicine, Rize, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahide Ciler","family":"Buyukatalay","sequence":"additional","affiliation":[{"name":"Department of Ear Nose and Throat, Ankara University School of Medicine, Ankara, Turkey, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep Celebi","family":"Sozener","sequence":"additional","affiliation":[{"name":"From the Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suna","family":"Buyukozturk","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Fuat","family":"Kalyoncu","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Chest Diseases, Hacettepe University School of Medicine, Ankara, 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