{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:27:14Z","timestamp":1785731234614,"version":"3.56.0"},"reference-count":33,"publisher":"Oceanside Publications Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> There are no published epidemiologic studies with regard to the prevalence of neurologic diseases among subjects with selective immunoglobulin A (IgA) deficiency (sIgAD).  <jats:bold>Objective:<\/jats:bold> To investigate the prevalence of neurologic diseases among\n the Israeli population with sIgAD.  <jats:bold>Methods:<\/jats:bold> A population-based case-control study among members of a large nationwide health maintenance organization in Israel providing services to &gt; 700,000 members. The sIgAD group included individuals \u22654 years of age with a serum\n IgA level of &lt;0.07 g\/L and with a diagnosis of sIgAD. The control group was randomly sampled from the entire study population with a case-control ratio of five controls for each case (1:5), with exact matching for age, gender, ethnic group, and socioeconomic status category.  <jats:bold>Results:<\/jats:bold>\n A total of 796 subjects ages 20.58 \u00b1 15.46 years; 391 female subjects (49.1%) were identified as having sIgAD. The control group was constituted of 3980 matched subjects. The sIgAD group was characterized by a higher prevalence of autism spectrum disorder and tic disorders. Migraine\n was less prevalent in the sIgAD group (19 [2.39%]) than in the control group (168 [4.22%]), odds ratio (OR) 0.55 (95% confidence interval {CI}, 0.34\u20100.90); p\u2009=\u20090.016]. More cases of subjects with epilepsy were observed in the sIgAD group (14 [1.76%]) than in the control\n group (31 [0.80%]), OR 2.28 (95% CI, 1.12 \u2010 4.44; p\u2009=\u20090.015).  <jats:bold>Conclusion:<\/jats:bold> Our observation raises the question of the role of IgA in noninfectious diseases of the central nervous system. Further basic studies are needed to explain our observation.<\/jats:p>","DOI":"10.2500\/aap.2023.44.230036","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T07:34:46Z","timestamp":1693985686000},"page":"e17-e21","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of neurological diseases among patients with selective IgA deficiency"],"prefix":"10.2500","volume":"44","author":[{"given":"Eli","family":"Magen","sequence":"first","affiliation":[{"name":"From the Leumit Health Services, Tel Aviv-Yafo, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akim","family":"Geishin","sequence":"additional","affiliation":[{"name":"From the Leumit Health Services, Tel Aviv-Yafo, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Merzon","sequence":"additional","affiliation":[{"name":"From the Leumit Health Services, Tel Aviv-Yafo, 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