{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:40:20Z","timestamp":1777480820873,"version":"3.51.4"},"reference-count":9,"publisher":"Oceanside Publications Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"Background:<\/jats:bold> Common variable immunodeficiency disorder (CVID) is a condition associated with recurrent infections and non-infectious outcomes, including lung disease like bronchiectasis and granulomatous and lymphocytic interstitial lung diseases (GLILD), autoimmune disease,\n enteropathy, and lymphoma. Treatment involves initiation of replacement immunoglobulin (Ig), which is a lifelong commitment. Prior to Ig replacement, life expectancy for patients with CVID was less than 15 years. With replacement Ig, it has improved to over 50 years. In most cases, patients\n present to a clinician with a history of recurrent infections, and treatment is indicated. However, in patients with asymptomatic disease, the best timing to start treatment can be difficult to determine. Case:<\/jats:bold> We present a case of an otherwise healthy male who had an incidental\n diagnosis of CVID. Results:<\/jats:bold> Workup revealed hypogammaglobulinemia for over 30 year. Discussion:<\/jats:bold> Though successful in reducing infections, Ig replacement can come with many side effects, as well as a heavy medical burden to the patient and the healthcare\n system. It is also a big life adjustment, and can greatly affect a patient's quality of life. In the military, a diagnosis of an immunodeficiency, and the need for monthly intravenous immunoglobulin (IVIG) can be detrimental to deployment readiness, and a patient's military career. Risks and\n benefits need to be weighed prior to initiating Ig therapy.<\/jats:p>","DOI":"10.2500\/aap.2023.44.230054","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T04:34:07Z","timestamp":1698986047000},"page":"436-439","source":"Crossref","is-referenced-by-count":10,"title":["Navigating the management complexity in long-term asymptomatic immunodeficiency"],"prefix":"10.2500","volume":"44","author":[{"given":"Katherine","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel U.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.7205\/MILMED-D-14-00739","article-title":"A brief description of the operation of the DoD serum repository","volume":"180","author":"Perdue","year":"2015","journal-title":"Mil Med"},{"key":"B2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaip.2015.07.025","article-title":"International Consensus Document (ICON): common variable immunodeficiency disorders","volume":"4","author":"Bonilla","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s10875-022-01289-3","article-title":"Human inborn errors of immunity: 2022 update on the classification from the International Union of Immunological Societies Expert Committee","volume":"42","author":"Tangye","year":"2022","journal-title":"J Clin Immunol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1007\/s10875-022-01352-z","article-title":"The 2022 update of IUIS phenotypical classification for human inborn errors of immunity","volume":"42","author":"Bousfiha","year":"2022","journal-title":"J Clin Immunol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12016-019-08765-6","article-title":"Perspective: evolving concepts in the diagnosis and understanding of common variable immunodeficiency disorders (CVID)","volume":"59","author":"Ameratunga","year":"2020","journal-title":"Clin Rev Allergy Immunol"},{"key":"B6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1081-1206(10)60606-0","article-title":"Asymptomatic long-standing panhypogammaglobulinemia with impaired antibody responses","volume":"100","author":"Glaum","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3389\/fimmu.2019.01541","article-title":"The natural history of untreated primary hypogammaglobulinemia in adults: implications for the diagnosis and treatment of common variable immunodeficiency disorders (CVID)","volume":"10","author":"Ameratunga","year":"2019","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13223-022-00661-7","article-title":"Monitoring patients with uncomplicated common variable immunodeficiency: a systematic review","volume":"18","author":"Lee","year":"2022","journal-title":"Allergy Asthma Clin Immunol"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1190235","DOI":"10.3389\/fimmu.2023.1190235","article-title":"Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review","volume":"14","author":"Bintalib","year":"2023","journal-title":"Front Immunol"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2023\/00000044\/00000006\/art00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T04:48:07Z","timestamp":1699591687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2023.44.230054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11,1]]}},"alternative-id":["1088-5412(20231101)44:6L.436;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2023.44.230054","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,1]]}}}