{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T05:20:00Z","timestamp":1722057600782},"reference-count":15,"publisher":"Oceanside Publications Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["allergy asthma proc"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"Background:<\/jats:bold> Research surrounding the coronavirus disease 2019 (COVID-19) pandemic and its impact on patients who are atopic has mainly focused on adults. After the delta variant showed increased rates of COVID-19 in children, the pediatric population needs to be assessed\n as well. Objective:<\/jats:bold> The objective was to assess and report outcomes in patients with COVID-19 and with and without certain atopic diseases in our patient cohort at the University of Mississippi Medical Center. Methods:<\/jats:bold> We conducted a retrospective review\n of patients by using a de-identified data base that allows querying via medical claims codes from the University of Mississippi Medical Center's Research Data Warehouse. We searched for patients who were COVID-19 positive and ages 0\u201021 years from January 1, 2020, to December 31, 2021.\n We then divided this population into two cohorts: an atopic population and a non-atopic population. The incidence of hospitalizations, intensive care unit (ICU) admissions, death, length of stay, inhaled corticosteroid prescription history, and the incidence of multi-system inflammatory syndrome\n in children (MIS-C) outcomes in the two populations were collected. Results:<\/jats:bold> There were 5261 patients ages 0\u201021 years and with confirmed COVID-19. After exclusion criteria were applied, there were 1420 patients in the atopic cohort and 2525 patients in the non-atopic\n cohort. There were more hospitalizations and a longer length of stay in the atopic population. Mortality was equivalent in the atopic and non-atopic populations. There were more ICU admissions in the atopic population. There were 101 patients total with the diagnosis of MIS-C, and the incidence\n of MIS-C was similar in the atopic and non-atopic populations. There were more patients who were atopic on inhaled corticosteroid than were the patients who were non-atopic. Conclusion:<\/jats:bold> This study sought to further elucidate whether asthma, atopic dermatitis, and allergic\n rhinitis in pediatric patients was associated with severe COVID-19. Our study showed increased hospitalizations, length of stay, and intensive care in the atopic population but similar outcomes in mortality and the development of MIS-C. Future longitudinal prospective studies are needed to\n assess the long-term effects on patient's atopic disease after COVID-19 infection.<\/jats:p>","DOI":"10.2500\/aap.2024.45.230087","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T04:30:48Z","timestamp":1709785848000},"page":"92-96","source":"Crossref","is-referenced-by-count":1,"title":["Assessing severity of COVID-19 and the development of multi system inflammatory syndrome in children (MIS-C) in pediatric patients with atopic disease"],"prefix":"10.2500","volume":"45","author":[{"given":"Natalie E.","family":"Rudsenske","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica B.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1355","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3390\/ijerph18031093","article-title":"COVID-19 and pediatric asthma: clinical and management challenges","volume":"18","author":"Boechat","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"B2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1164\/rccm.202003-0821OC","article-title":"COVID-19-related genes in sputum cells in asthma. relationship to demographic features and corticosteroids","volume":"202","author":"Peters","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"B3","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/all.14452","article-title":"Clinical characteristics of 182 pediatric COVID-19 patients with different severities and allergic status","volume":"76","author":"Du","year":"2021","journal-title":"Allergy"},{"key":"B4","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/all.14787","article-title":"Childhood asthma outcomes during the COVID-19 pandemic: findings from the PeARL multi-national cohort","volume":"76","author":"Papadopoulos","year":"2021","journal-title":"Allergy"},{"key":"B5","article-title":"Patient Cohort Explorer","year":"2020"},{"key":"B6","volume-title":"StatPearls [Internet]","author":"Justiz Vaillant","year":"2023"},{"key":"B7","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.1097\/DER.0000000000000881","article-title":"COVID-19 outcomes in pediatric patients with atopic dermatitis: a multicenter analysis","volume":"33","author":"Raiker","year":"2022","journal-title":"Dermatitis"},{"key":"B8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jdin.2021.12.007","article-title":"Association between atopic dermatitis and COVID-19 infection: a case-control study in the All of Us research program","volume":"6","author":"Fan","year":"2022","journal-title":"JAAD Int"},{"key":"B9","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jaci.2021.12.762","article-title":"Asthma and atopy in COVID-19: 2021 updates","volume":"149","author":"Carr","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B10","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2500\/aap.2021.42.210087","article-title":"Does aeroallergen sensitivity and allergic rhinitis in children cause milder COVID-19 infection?","volume":"42","author":"Vezir","year":"2021","journal-title":"Allergy Asthma Proc"},{"key":"B11","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jaci.2022.07.004","article-title":"Allergic sensitization impairs lung resident memory CD8 T-cell response and virus clearance","volume":"150","author":"Agrawal","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B12","doi-asserted-by":"crossref","first-page":"eabi9733","DOI":"10.1126\/sciimmunol.abi9733","article-title":"Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection","volume":"7","author":"Egholm","year":"2022","journal-title":"Sci Immunol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1164\/rccm.202107-1704OC","article-title":"Asthma phenotypes and COVID-19 risk: a population-based observational study","volume":"205","author":"Bloom","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"B14","doi-asserted-by":"crossref","first-page":"100443","DOI":"10.1016\/j.lanepe.2022.100443","article-title":"Risk factors for multisystem inflammatory syndrome in children - a population-based cohort study of over 2 million children","volume":"19","author":"Rhedin","year":"2022","journal-title":"Lancet Reg Health Eur"},{"key":"B15","article-title":"Diagnosed allergic conditions in children aged 0\u201317 years: United States, 2021. NCHS Data Brief, no. 459","author":"Zablotsky","year":"2023"}],"container-title":["Allergy and Asthma Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ocean\/aap\/2024\/00000045\/00000002\/art00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T04:32:25Z","timestamp":1722054745000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.2500\/aap.2024.45.230087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3,1]]}},"alternative-id":["1088-5412(20240301)45:2L.92;1-"],"URL":"https:\/\/doi.org\/10.2500\/aap.2024.45.230087","relation":{},"ISSN":["1088-5412"],"issn-type":[{"value":"1088-5412","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}